Abstract: The method includes: a first electronic device detects signal strength existing when the first electronic device communicates with a second electronic device, and determines whether the signal strength is less than a preset value; when the signal strength is less than the preset value, the first electronic device determines a current service state of the second electronic device, and determines, based on the current service state, working modes that respectively correspond to the first electronic device and the second electronic device and that are suitable for the current service state; and the first electronic device switches a working mode to the determined working mode that corresponds to the first electronic device and that is suitable for the current service state, and sends an instruction to indicate the second electronic device to switch a working mode to the determined working mode that corresponds to the second electronic device.

Abstract: Automated, image-guided systems for automatically performing in vitro cell patch clamping are provided. The systems are configured for use with a patch-clamp arrangement and include a camera system for providing images from tissues under investigation and a computer to execute calibration, detection, and whole-cell patching algorithms based on the collected image data. Automated methods for carrying out in vitro cell patch clamping using this automated, image-guided system are also provided and include using images to automatically calibrate a manipulator relative to a tissue of interest, detect and extract coordinates for a plurality of cells, and utilizing the coordinates with a patch-clamp arrangement to automatically move a manipulator directly above each of the plurality of cells and initiate the performance of an automated patch clamp mechanism for each of the plurality of cells driven by the system.

Abstract: Automated, image-guided systems for automatically performing in vitro cell patch clamping are provided. The systems are configured for use with a patch-clamp arrangement and include a camera system for providing images from tissues under investigation and a computer to execute calibration, detection, and whole-cell patching algorithms based on the collected image data. Automated methods for carrying out in vitro cell patch clamping using this automated, image-guided system are also provided and include using images to automatically calibrate a manipulator relative to a tissue of interest, detect and extract coordinates for a plurality of cells, and utilizing the coordinates with a patch-clamp arrangement to automatically move a manipulator directly above each of the plurality of cells and initiate the performance of an automated patch clamp mechanism for each of the plurality of cells driven by the system.