Abstract: The present disclosure discloses a hot-forging die with the conformal meshy structured cavity surface layer and a preparation method thereof. A large-scale hot-forging die includes a die substrate, and a sandwiched layer, a transition layer and a reinforcement layer are formed on the die substrate in sequence. The reinforcement layer and the transition layer are separated into a plurality of small units by the grooves. All the grooves are interconnected and communicated to form a meshy structure. The transition layer grooves are filled with ordinary soft material; the reinforcement layer grooves are filled with high temperature resistant soft material.

Abstract: This disclosure provides a method for generating a personalized product description based on multi-source crowd data, which includes following steps: collecting data required for the personalized product description, the required data including reviews for crowd products and historical reviews of a crowd of users; portraiting the product and user to obtain a user preference label and a product label, which are then matched to obtain a personalized preference label; and generating the personalized product description in conjunction with the personalized preference labels. For different product attributes, different text generation methods are employed, and with different characteristics of the text generation methods such as extracted text generation and generated text generation, multi-source data are fused, so that the generated product description is smoother.

Abstract: The present disclosure discloses a hot-forging die with the conformal meshy structured cavity surface layer and a preparation method thereof. A large-scale hot-forging die includes a die substrate, and a sandwiched layer, a transition layer and a reinforcement layer are formed on the die substrate in sequence. The reinforcement layer and the transition layer are separated into a plurality of small units by the grooves. All the grooves are interconnected and communicated to form a meshy structure. The transition layer grooves are filled with ordinary soft material; the reinforcement layer grooves are filled with high temperature resistant soft material.

Abstract: Provided are siRNAs or chemically-modified siRNAs targeted against ADAMTS-5 or ADAM17 for inhibiting the expression of ADAMTS-5 or ADAM17. Use of the siRNAs for treating an ADAMTS-5 or ADAM17 associated disease, such as arthritis and other inflammation-related diseases, by injecting the siRNAs or preparations comprising the siRNAs into an articular cavity of the patient, are also provided.

Abstract: Provided are siRNAs or chemically-modified siRNAs targeted against ADAMTS-5 or ADAM17 for inhibiting the expression of ADAMTS-5 or ADAM17. Use of the siRNAs for treating an ADAMTS-5 or ADAM17 associated disease, such as arthritis and other inflammation-related diseases, by injecting the siRNAs or preparations comprising the siRNAs into an articular cavity of the patient, are also provided.