Abstract: Embodiments of the present disclosure relate to configuration-based sampling of run segments for simulating autonomous vehicle behavior. In at least one implementation, a method comprises: providing a set of run segments corresponding to scenarios for simulating operation of an autonomous vehicle; receiving a user-specified configuration comprising parameters for identifying target run segments within the set of run segments; applying the user-specified configuration to the set of run segments to identify the target run segments; and causing one or more simulations to be performed using the target run segments to generate a simulation output.