Patents by Inventor Qiyong Peter Liu

Qiyong Peter Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220040110
    Abstract: A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (SDSAS) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compostions related to plasma dried by the methods of the present invention.
    Type: Application
    Filed: October 22, 2021
    Publication date: February 10, 2022
    Applicant: Velico Medical Inc.
    Inventors: Qiyong Peter Liu, Junqing Cui, Rud Karly Lucien, Ryan Carney, Jihae Sohn, Michelle Arya
  • Publication number: 20210290545
    Abstract: A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (SDSAS) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.
    Type: Application
    Filed: June 2, 2021
    Publication date: September 23, 2021
    Applicant: Velico Medical Inc.
    Inventors: Qiyong Peter Liu, Junqing Cui, Rud Karly Lucien, Ryan Carney, Jihae Sohn, Michelle Arya
  • Patent number: 11052045
    Abstract: A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (SDSAS) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: July 6, 2021
    Assignee: Velico Medical, Inc.
    Inventors: Qiyong Peter Liu, Junqing Cui, Rud Karly Lucien, Ryan Carney, Jihae Sohn, Michelle Arya
  • Publication number: 20190246629
    Abstract: The present invention relates to methods and compositions for reducing sialidase activity and inhibiting bacterial proliferation of one or more bacteria in a platelet product preparation from one or more donors. In general, the method includes contacting the platelet product preparation with an amount of a sialidase inhibitor, to thereby obtain a sialidase inhibitor-treated platelet product preparation. Sialidase activity is reduced and the proliferation of one or more bacteria is inhibited, as compared to a platelet product preparation not subjected to the sialidase inhibitor treatment.
    Type: Application
    Filed: April 22, 2019
    Publication date: August 15, 2019
    Applicants: Velico Medical, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Publication number: 20190203175
    Abstract: The present invention relates to a platelet protection solution (PPS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PPS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Application
    Filed: September 10, 2018
    Publication date: July 4, 2019
    Applicant: Velico Medical, Inc.
    Inventor: Qiyong Peter Liu
  • Publication number: 20190200602
    Abstract: The present invention relates to a platelet additive solution (PAS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Application
    Filed: March 5, 2019
    Publication date: July 4, 2019
    Applicants: Velico Medical, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, M, Robert Sackstein
  • Patent number: 10271541
    Abstract: The present invention relates to a platelet additive solution (PAS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: April 30, 2019
    Assignees: Velico Medical, Inc, The Brigham and Women's Hospital, Inc.
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Publication number: 20180000066
    Abstract: The present invention relates to a platelet protection solution (PPS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PPS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Application
    Filed: September 13, 2017
    Publication date: January 4, 2018
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Publication number: 20170367322
    Abstract: The present invention relates to a reconstitution solution for spray dried plasma having a non-anticoagulant compound that does not bind calcium. When the reconstitution solution of the present invention is mixed with spray dry plasma, the reconstituted plasma mediates platelet adhesion and aggregation about the same as or greater than the starting plasma prior to spray drying. The present invention also relates to an assay for determining platelet adhesion and aggregation using microfluidic flow cell system having a shear flow. The assay assesses labeled whole blood samples having reconstituted plasma having spray dried plasma and a reconstitution solution; platelets; and red blood cells. After inducing a shear flow under conditions suitable for clot formation, coverage area of the platelets, intensity of the platelets, morphology, or a combination thereof is detected to determine platelet accumulation (e.g., platelet adhesion and aggregation).
    Type: Application
    Filed: April 7, 2017
    Publication date: December 28, 2017
    Inventors: Qiyong Peter Liu, Ryan Christopher Carney
  • Publication number: 20170370952
    Abstract: The present invention relates to a reconstitution solution for spray dried plasma having a non-anticoagulant compound that does not bind calcium. When the reconstitution solution of the present invention is mixed with spray dry plasma, the reconstituted plasma mediates platelet adhesion and aggregation about the same as or greater than the starting plasma prior to spray drying. The present invention also relates to an assay for determining platelet adhesion and aggregation using microfluidic flow cell system having a shear flow. The assay assesses labeled whole blood samples having reconstituted plasma having spray dried plasma and a reconstitution solution; platelets; and red blood cells. After inducing a shear flow under conditions suitable for clot formation, coverage area of the platelets, intensity of the platelets, morphology, or a combination thereof is detected to determine platelet accumulation (e.g., platelet adhesion and aggregation).
    Type: Application
    Filed: April 7, 2017
    Publication date: December 28, 2017
    Inventors: Qiyong Peter Liu, Ryan Christopher Carney, Andrew Peter Cap, Michael Adam Meledeo
  • Patent number: 9788539
    Abstract: The present invention relates to a platelet protection solution (PPS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PPS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: October 17, 2017
    Assignees: Velico Medical, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Publication number: 20170156310
    Abstract: The present invention relates to a platelet additive solution (PAS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Application
    Filed: February 17, 2017
    Publication date: June 8, 2017
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Publication number: 20170100339
    Abstract: A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (SDSAS) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.
    Type: Application
    Filed: December 19, 2016
    Publication date: April 13, 2017
    Applicant: Velico Medical, Inc.
    Inventors: Qiyong Peter Liu, Junqing Cui, Rud Karly Lucien, Ryan Carney, Jihae Sohn, Michelle Arya
  • Patent number: 9609861
    Abstract: The present invention relates to a platelet additive solution (PAS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: April 4, 2017
    Assignees: Velico Medical Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Patent number: 9561184
    Abstract: Disclosed are methods of spray drying blood plasma using a two-step drying process.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: February 7, 2017
    Assignee: Velico Medical, Inc.
    Inventors: Abdul Wahid Khan, Michael Wilt, Rud Karly Lucien, Jihae Sohn, Qiyong Peter Liu
  • Patent number: 9545379
    Abstract: A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (SDSAS) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: January 17, 2017
    Assignee: Velico Medical, Inc.
    Inventors: Qiyong Peter Liu, Junqing Cui, Rud Karly Lucien, Ryan Carney, Jihae Sohn, Michelle Arya
  • Publication number: 20160174543
    Abstract: The present invention relates to a platelet additive solution (PAS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Application
    Filed: October 7, 2013
    Publication date: June 23, 2016
    Applicants: The Brigham and Women's Hospital, Inc., Velico Medical, Inc.
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Publication number: 20160143269
    Abstract: The present invention relates to a platelet protection solution (PPS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PPS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Application
    Filed: February 2, 2016
    Publication date: May 26, 2016
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Publication number: 20160145573
    Abstract: The present invention relates to a platelet protection solution (PPS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PPS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Application
    Filed: February 2, 2016
    Publication date: May 26, 2016
    Inventor: Qiyong Peter Liu
  • Publication number: 20160082044
    Abstract: A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (SDSAS) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.
    Type: Application
    Filed: September 18, 2015
    Publication date: March 24, 2016
    Inventors: Qiyong Peter Liu, Junqing Cui, Rud Karly Lucien, Ryan Carney, Jihae Sohn, Michelle Arya