Abstract: The present invention belongs to the field of genetic engineering, and particularly relates to a genetically engineered dual-targeting chimeric antigen receptor. The present invention provides a genetically engineered dual-targeting chimeric antigen receptor and a host cell thereof in response to up-regulated expression of PD-L1 in tumor cells and immune cells after these cells are exposed to malignant serosal cavity effusion. The dual-targeting chimeric antigen receptor provided by the present invention competitively binds to PD-L1 to transform an inhibition signal of PD-L1 into an activation signal and to enhance the killing activity of T cells; meanwhile, 4-1BB introduced downstream thereof can promote proliferation and survival of T cells. In addition, the present invention also discloses a host cell expressing the above dual-targeting antigen receptor and a use thereof in preventing or treating solid tumors.

Abstract: A seed development device for Psammochloa villosa using condensate water in desert areas includes: a cultivation box, a top surface of the cultivation box is connected to a cooler and condensate water collecting units through a support frame. Each condensate water collecting unit includes an outer frame, sleeve pipes, a middle frame, a cold air cavity, water collecting rods, a water collecting tank and a delivery pipe. The delivery pipe is connected to the cultivation box. When an outdoor temperature cannot complete condensation of water vapor, the cooler completes cooling of the cold air cavity and water collecting rods until condensate water collection is completed, water drops fall into the water collecting tank to complete water collection, which is used for water supplement of seed development of Psammochloa villosa, thus reducing the process of artificial water supplement and improving the development efficiency of seeds of Psammochloa villosa in desert areas.

Abstract: A seed development device for Psammochloa villosa using condensate water in desert areas includes: a cultivation box, a top surface of the cultivation box is connected to a cooler and condensate water collecting units through a support frame. Each condensate water collecting unit includes an outer frame, sleeve pipes, a middle frame, a cold air cavity, water collecting rods, a water collecting tank and a delivery pipe. The delivery pipe is connected to the cultivation box. When an outdoor temperature cannot complete condensation of water vapor, the cooler completes cooling of the cold air cavity and water collecting rods until condensate water collection is completed, water drops fall into the water collecting tank to complete water collection, which is used for water supplement of seed development of Psammochloa villosa, thus reducing the process of artificial water supplement and improving the development efficiency of seeds of Psammochloa villosa in desert areas.

Abstract: A rhizome-growth monitoring device of a clonal plate is provided, including a supporting frame. A first adjustment rack is fixed above a side of the supporting frame, a side end of which is movably connected to a second adjustment rack. A connection sleeve is movably connected to a bottom end of the second adjustment rack. A lifting cylinder is fixed in the connection sleeve. A camera group is fixed to the lifting cylinder through a connection plate. A rhizome growth monitoring sleeve is fixed at a bottom end of the connection plate, and includes an outer sleeve, an inner sleeve, and a radar monitoring head. The outer sleeve is fixed onto the bottom end of the connection plate. The inner sleeve is screwed to an inner side of the outer sleeve. The radar monitoring head is installed in the inner sleeve and close to a bottom surface thereof.

Abstract: A rhizome-growth monitoring device of a clonal plate is provided, including a supporting frame. A first adjustment rack is fixed above a side of the supporting frame, a side end of which is movably connected to a second adjustment rack. A connection sleeve is movably connected to a bottom end of the second adjustment rack. A lifting cylinder is fixed in the connection sleeve. A camera group is fixed to the lifting cylinder through a connection plate. A rhizome growth monitoring sleeve is fixed at a bottom end of the connection plate, and includes an outer sleeve, an inner sleeve, and a radar monitoring head. The outer sleeve is fixed onto the bottom end of the connection plate. The inner sleeve is screwed to an inner side of the outer sleeve. The radar monitoring head is installed in the inner sleeve and close to a bottom surface thereof.

Abstract: A method for extracting f wave from a single-lead electrocardiography signal is provided. The method includes: establishing a two-channel temporal convolutional neural network model, including two coding submodules, two mask estimation submodules, an information fusion module and two decoding submodules; constructing a training data set of ECG signals; training the two-channel temporal convolutional neural network model, and saving the trained model. The two-channel temporal convolution neural network encodes and decodes a QRST complex and the f wave respectively, and uses a mask of information fusion to estimate and construct regular items to restrict a distribution difference of QRST component coding features, so as to reduce the distortion of the QRST complex, select potential features of a QRST complex and f wave with high signal-to-noise ratio, and thus improve a detection accuracy of the f wave.

Abstract: The present invention belongs to the field of genetic engineering, and particularly relates to a genetically engineered dual-targeting chimeric antigen receptor. The present invention provides a genetically engineered dual-targeting chimeric antigen receptor and a host cell thereof in response to up-regulated expression of PD-L1 in tumor cells and immune cells after these cells are exposed to malignant serosal cavity effusion. The dual-targeting chimeric antigen receptor provided by the present invention competitively binds to PD-L1 to transform an inhibition signal of PD-L1 into an activation signal and to enhance the killing activity of T cells; meanwhile, 4-1BB introduced downstream thereof can promote proliferation and survival of T cells. In addition, the present invention also discloses a host cell expressing the above dual-targeting antigen receptor and a use thereof in preventing or treating solid tumors.

Abstract: A method for extracting f wave from a single-lead electrocardiography signal is provided. The method includes: establishing a two-channel temporal convolutional neural network model, including two coding submodules, two mask estimation submodules, an information fusion module and two decoding submodules; constructing a training data set of ECG signals; training the two-channel temporal convolutional neural network model, and saving the trained model. The two-channel temporal convolution neural network encodes and decodes a QRST complex and the f wave respectively, and uses a mask of information fusion to estimate and construct regular items to restrict a distribution difference of QRST component coding features, so as to reduce the distortion of the QRST complex, select potential features of a QRST complex and f wave with high signal-to-noise ratio, and thus improve a detection accuracy of the f wave.