Abstract: Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.

Abstract: The present disclosure relates generally to regulatory T cells (Tregs) engineered to express a dipeptidyl aminopeptidase-like protein 6 (DPP6)-reactive chimeric antigen receptor (CAR). The engineered Tregs are suitable for use in immunotherapy regimens for autoimmune, inflammatory and degenerative diseases. In particular, the anti-DPP6 CAR expressing Tregs are suitable for treating or preventing autoimmune diseases of the pancreas or central nervous system.

Abstract: The present disclosure relates generally to the field of immuno-therapeutics, and particularly relates to novel chimeric polypeptides, e.g., chimeric antigen receptors (CARs) that include a transmembrane domain from CD28 and a hinge domain. In some cases, the hinge domain is capable of promoting dimerization of the CARs. The disclosure also provides compositions and methods useful for producing such molecules, as well as methods for the detection and treatment of health conditions, such as proliferative diseases (e.g., cancer).

Abstract: The present disclosure discloses a NVM-based method for performance acceleration of containers. The method comprises classifying each image layer of mirror images as either an LAL (Layer above LDL) or an LBL (Layer below LDL) during deployment of containers; storing the LALs into a non-volatile memory and selectively storing each said LBL into one of the non-volatile memory and a hard drive; acquiring hot image files required by the containers during startup and/or operation of the containers and storing the hot image files required by the containers into the non-volatile memory; and sorting the mirror images in terms of access frequency according to at least numbers of times of access to the hot image files so as to release the non-volatile memory currently occupied by the mirror image having the lowest access frequency when the non-volatile memory is short of storage space.

Abstract: The present disclosure relates generally to the manufacture of regulatory T cells (Tregs) for use in adoptive cell therapy. In particular, the present disclosure relates to simplified approaches for the expansion of Tregs ex vivo. Tregs produced in this way are suitable for use in various immunotherapy regimens.

Abstract: The invention provides LFA3 polypeptide molecules, e.g., variant LFA3 fusion polypeptide molecules. The invention includes uses, and associated methods of using the LFA3 polypeptide molecules.

Abstract: Chimeric antigen receptor (CAR)-expressing T regulatory cells (Tregs) include intracellular co-stimulatory or inhibitory domains based on the biology, functions and activities of Tregs. The co-stimulatory or inhibitory domains modulate the Treg response, thereby, activating or suppressing an effector T cell (Teff) immune response to specific antigens.

Abstract: Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.

Abstract: The present disclosure discloses a NVM-based method for performance acceleration of containers. The method comprises classifying each image layer of mirror images as either an LAL (Layer above LDL) or an LBL (Layer below LDL) during deployment of containers; storing the LALs into a non-volatile memory and selectively storing each said LBL into one of the non-volatile memory and a hard drive; acquiring hot image files required by the containers during startup and/or operation of the containers and storing the hot image files required by the containers into the non-volatile memory; and sorting the mirror images in terms of access frequency according to at least numbers of times of access to the hot image files so as to release the non-volatile memory currently occupied by the mirror image having the lowest access frequency when the non-volatile memory is short of storage space.

Abstract: The present disclosure relates generally to the manufacture of regulatory T cells (Tregs) for use in immunotherapy. In particular, the present disclosure relates to robust approaches for the expansion of alloantigen-reactive Tregs ex vivo. Alloantigen-reactive Tregs produced in this way are suitable for the induction and/or maintenance of immunologic tolerance in recipients of allogeneic transplants.

Abstract: The present disclosure relates generally to the manufacture of regulatory T cells (Tregs) for use in immunotherapy. In particular, the present disclosure relates to robust approaches for the expansion of alloantigen-reactive Tregs ex vivo. Alloantigen-reactive Tregs produced in this way are suitable for the induction and/or maintenance of immunologic tolerance in recipients of allogeneic transplants.

Abstract: The present disclosure relates generally to the manufacture of regulatory T cells (Tregs) for use in immunotherapy. In particular, the present disclosure relates to robust approaches for the expansion of alloantigen-reactive Tregs ex vivo. Alloantigen-reactive Tregs produced in this way are suitable for the induction and/or maintenance of immunologic tolerance in recipients of allogeneic transplants.

Abstract: The invention provides methods for producing an autoantigen-specific regulatory T cell enriched composition, and resultant compositions and methods for use.

Abstract: The invention provides methods for producing an autoantigen-specific regulatory T cell enriched composition, and resultant compositions and methods of use.

Abstract: The invention provides methods for producing an autoantigen-specific regulatory T cell enriched composition, and resultant compositions and methods of use.

Abstract: The invention provides methods for producing an autoantigen-specific regulatory T Cell enriched composition, and resultant compositions and methods of use.