Abstract: Embodiments of this invention includes a stator exhibiting improved electrical and thermal properties for electrical machines, for example, motors and generators having a number of applications including but not limited to electronic axle (e-axle) used in a variety of automobiles, among others, where the coil temperature of the e-axle during operation is much reduced thus improving the performance of the motor. The stator in accordance of this invention is made by a single molding process using a mesh to separate the metal wires from the body of the stator. Also disclosed and claimed is a method of molding the stator.

Abstract: Provided herein are inhibitors of DNA methyltransferase 1 (an enzyme responsible for the maintenance of DNA CpG methylation marks in human cells) and their use for inhibiting DNA methyltransferase 1. The invention relates to compounds, pharmaceutical compositions, and methods for inhibiting DNA methyltransferase 1.

Abstract: Methods and systems for obtaining inhibitors of human DNA methyltransferase 1 (DNMT1) are disclosed where the methods involve designing compounds that resemble the DNMT1 transition state.

Abstract: Methods and systems for obtaining inhibitors of human DNA methyltransferase 1 (DNMT1) are disclosed where the methods involve designing compounds that resemble the DNMT1 transition state.

Abstract: Inhibitors of DNA methyltransferase 1 (an enzyme responsible for the maintenance of DNA CpG methylation marks in human cells) and their use as therapeutic agents against various cancers. The invention relates to compounds, pharmaceutical compositions, methods for inhibiting DNA methyltransferase 1, and methods for treating cancer. The inhibitors are compounds of the general formula.

Abstract: Methods and systems for obtaining inhibitors of human DNA methyltransferase 1 (DNMT1) are disclosed where the methods involve designing compounds that resemble the DNMT1 transition state.

Abstract: The present invention discloses preparation and application of double-stranded RNA molecules stable in mammalian body fluids. The mammalian-body-fluid-stable RNA molecules disclosed in the present invention are comprised of only unmodified nucleotides. For the first time, the present invention discloses the applications of mammalian-body-fluid-stable RNA molecules for immunotherapy and siRNA drug development.

Abstract: The present invention discloses preparation and application of double-stranded RNA molecules stable in mammalian body fluids. The mammalian-body-fluid-stable RNA molecules disclosed in the present invention are comprised of only unmodifide nucleotides. For the first time, the present invention discloses the applications of mammalian-body-fluid-stable RNA molecules for immunotherapy and siRNA drug development.

Abstract: A bezel mounting assembly includes a bezel (10), a front panel (30) defining a pair of apertures (31), and a locking device (20) attached to the bezel for securing the bezel to the front panel. The bezel includes a pair of pillars (121) and a pair of blocks (11) having a pair of posts (14). The locking device includes a pair of symmetric side plates (22) defining through slots (25) for slidably receiving the posts, a pair of resilient arms (27) extending from the side plates, an operating member (23), and a pair of catches (26). The locking device is slidably attached on the blocks, with the posts engagingly received in the through slots. The resilient arms are secured to the pillars at free ends thereof. The operating member is moved vertically so as to drive the catches to engage in and disengage from the apertures of the front panel.

Abstract: An enhanced operating environment for an Interactive Real-Time Distributed Navigation system is disclosed. In the present invention, an enhanced operating environment is provided by improving input and output techniques in a navigation system. Disclosed are methods for reducing the number of inputs to a navigational sytstem through a wireless device. Improved input methods include methods for entering non-deterministic information to retrieve deterministic information. Also disclosed are improved output techniques including methods for pacing navigational prompts provided by a navigation system. The invention is applicable to text, graphics or audible navigation systems.

Abstract: A method and system for interactive real-time distributed navigation employs improved techniques for input and output. The method and system may receive inputs through a wireless device. The operating environment simplifies and reduces these inputs. In some embodiments, the system receives non-deterministic input to generate deterministic information using a number of methods. The system may also employ improved output techniques including methods for pacing navigational prompts provided by a navigation system, and methods of providing navigational information to a number of users. The method and system are applicable to text, graphics or audible navigation systems.