Patents by Inventor Quan Lu

Quan Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11938337
    Abstract: A system and method for mind-body relaxation may include a plurality of vibration modules, a light-providing member, a controller, a relaxation substrate, a pillow member, a graphical user interface (GUI), and network connection circuitry.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: March 26, 2024
    Inventors: Sang Phu Huynh, Thai Quan Nguyen, Nga Thi Thanh Nguyen, Tuong Huu Tran, Dang Minh Lu, Phuoc Thi Le Tran
  • Publication number: 20240082420
    Abstract: Methods, systems, compositions and strategies for the delivery of RNA into cells in vivo, ex vivo, or in vitro via ARMMs are provided. In some aspects, ARMMs containing fusion proteins of ARRDC1 fused to an RNA binding protein or an RNA binding protein fused to a WW domain are provided. In some aspects, ARMMs containing binding RNAs associated with cargo RNAs are provided. In other aspects, cargo RNAs associated with a binding RNA, such as a TAR element, are loaded into ARMMs via ARRDC1 fusion proteins containing an RNA binding protein, such as trans-activator of transcription (Tat) protein.
    Type: Application
    Filed: June 28, 2023
    Publication date: March 14, 2024
    Applicant: President and Fellows of Harvard College
    Inventor: Quan Lu
  • Publication number: 20230398202
    Abstract: Disclosed herein are methods, systems, compositions and strategies for the creation and use WW-domain-Activated Extracellular Vesicles, or WAEVs. These WAEVs can be harnessed to deliver and present viral or bacterial antigens useful for vaccine development; to display homing molecules for targeted delivery of therapeutic molecules to specific cells or tissues; and for packaging and delivery of therapeutic molecules via interactions with the WW domains.
    Type: Application
    Filed: October 15, 2021
    Publication date: December 14, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: Quan Lu, Sengjin Choi
  • Publication number: 20230391834
    Abstract: Disclosed herein are methods, systems, compositions and strategies for the creation and use WW-domain-Activated Extracellular Vesicles, or WAEVs for presenting SARS-CoV-2 antigen domains, for example the SARS-CoV-2 M protein, the SARS-CoV-2 E protein, or the SARS-CoV-2 S protein. These WAEVs can be harnessed to deliver and present SARS-CoV-2 antigens useful for vaccine development.
    Type: Application
    Filed: October 15, 2021
    Publication date: December 7, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: Quan Lu, Sengjin Choi
  • Publication number: 20230390382
    Abstract: Disclosed herein are methods, systems, compositions and strategies for the creation and use WW-domain-Activated Extracellular Vesicles (WAEVs) for presenting HIV antigen domains. These WAEVs can be harnessed to deliver and present HIV antigens useful for vaccine development. Specifically, the disclosure provides a fusion protein comprising: (a) a WW-containing domain; (b) a transmembrane domain; and (c) an extracellular domain, wherein the extracellular domain is an HIV antigen domain. Further provided are sequences of each domain as well as methods of producing and using the fusion protein.
    Type: Application
    Filed: October 15, 2021
    Publication date: December 7, 2023
    Applicants: President and Fellows of Harvard College, Board of Regents of the University of Nebraska
    Inventors: Quan Lu, Shi-Hua Xiang
  • Patent number: 11827910
    Abstract: Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: November 28, 2023
    Assignees: President and Fellows of Harvard College, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Quan Lu, Qiyu Wang, Stanley N. Cohen
  • Patent number: 11730823
    Abstract: Methods, systems, compositions and strategies for the delivery of RNA into cells in vivo, ex vivo, or in vitro via ARMMs are provided. In some aspects, ARMMs containing fusion proteins of ARRDC1 fused to an RNA binding protein or an RNA binding protein fused to a WW domain are provided. In some aspects, ARMMs containing binding RNAs associated with cargo RNAs are provided. In other aspects, cargo RNAs associated with a binding RNA, such as a TAR element, are loaded into ARMMs via ARRDC1 fusion proteins containing an RNA binding protein, such as trans-activator of transcription (Tat) protein.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: August 22, 2023
    Assignee: President and Fellows of Harvard College
    Inventor: Quan Lu
  • Publication number: 20230227852
    Abstract: Methods, systems, compositions and strategies for the use of ARMM-mediated delivery of molecules (e.g., biological molecules, small molecules, proteins, and nucleic acids (e.g., DNA, RNA), DNA plasmids shRNA, mRNA) to cells of the nervous system (e.g., central nervous system and peripheral nervous system).
    Type: Application
    Filed: June 11, 2021
    Publication date: July 20, 2023
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation, Vesigen, Inc.
    Inventors: Quan Lu, Stephen J. Haggarty, Robert Millman
  • Publication number: 20220403003
    Abstract: Disclosed herein are minimal arrestin domain containing protein 1 (ARRDC1) constructs, which drive the formation of ARRDC1-mediated microvesicles (ARMMs). These vesicles can be harnessed to package and deliver a variety of molecular cargos such as small molecules, nucleic acids, and proteins. An example of such cargo is the genome editor Cas9.
    Type: Application
    Filed: September 25, 2020
    Publication date: December 22, 2022
    Applicant: President and Fellows of Harvard College
    Inventors: Quan Lu, Qiyu Wang
  • Publication number: 20210315814
    Abstract: The invention provide isolated arrestin domain-containing protein 1 (ARRDC1)-mediated microvesicles (ARMMs). Methods for generating and for isolating ARMMs are also provided herein. ARMMs can be used to deliver agents, for example, nucleic acids (e.g., siRNAs, microRNAs, lincRNAs), proteins (e.g., transcription factors, chromatin modulators, kinases, phosphorylases, or recombinases), or small molecules to target cells in vitro and in vivo, and methods for such ARMM-mediated delivery are provided herein. Diagnostic and therapeutic methods using ARMMs are also described herein.
    Type: Application
    Filed: February 5, 2021
    Publication date: October 14, 2021
    Applicants: President and Fellows of Harvard College, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Quan Lu, Joseph F. Nabhan, Stanley N. Cohen
  • Publication number: 20210261930
    Abstract: Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.
    Type: Application
    Filed: February 5, 2021
    Publication date: August 26, 2021
    Applicants: President and Fellows of Harvard College, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Quan Lu, Qiyu Wang, Stanley N. Cohen
  • Publication number: 20210213139
    Abstract: Methods, systems, compositions and strategies for the delivery of RNA into cells in vivo, ex vivo, or in vitro via ARMMs are provided. In some aspects, ARMMs containing fusion proteins of ARRDC1 fused to an RNA binding protein or an RNA binding protein fused to a WW domain are provided. In some aspects, ARMMs containing binding RNAs associated with cargo RNAs are provided. In other aspects, cargo RNAs associated with a binding RNA, such as a TAR element, are loaded into ARMMs via ARRDC1 fusion proteins containing an RNA binding protein, such as trans-activator of transcription (Tat) protein.
    Type: Application
    Filed: October 3, 2017
    Publication date: July 15, 2021
    Applicant: President and Fellows of Harvard College
    Inventor: Quan Lu
  • Patent number: 11001817
    Abstract: Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of cargo proteins into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: May 11, 2021
    Assignees: President and Fellows of Harvard College, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Quan Lu, Qiyu Wang, Stanley N. Cohen
  • Patent number: 10945954
    Abstract: The invention provide isolated arrestin domain-containing protein 1 (ARRDC1)-mediated microvesicles (ARMMs). Methods for generating and for isolating ARMMs are also provided herein. ARMMs can be used to deliver agents, for example, nucleic acids (e.g., siRNAs, microRNAs, lincRNAs), proteins (e.g., transcription factors, chromatin modulators, kinases, phosphorylases, or recombinases), or small molecules to target cells in vitro and in vivo, and methods for such ARMM-mediated delivery are provided herein. Diagnostic and therapeutic methods using ARMMs are also described herein.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: March 16, 2021
    Assignees: President and Fellows of Harvard College, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Quan Lu, Joseph F. Nabhan, Stanley N. Cohen
  • Patent number: 10757203
    Abstract: Systems, methods, and apparatuses are disclosed for generating mapping data structures based on predicted relationships across tracking data obtained from tracking online browsing histories of users to a network of websites.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: August 25, 2020
    Assignee: Oath Inc.
    Inventors: Liang Wang, Kuang-chih Lee, Quan Lu
  • Publication number: 20200059021
    Abstract: In one embodiment, an eye of needle (EON) press-fit pin includes a base, a tip, and a compliant portion extending longitudinally between the base and the tip and comprising a pair of resilient deformable arms joined at opposite ends and defining an opening therebetween. The arms each include an outer surface for at least partial engagement with walls of an electrical via upon insertion therein. The outer surface of each of the arms includes a central segment having a flat longitudinal surface and converges from the central segment towards the base and the tip. The arms each further include an inner surface defining the opening and forming an elongated portion at each end of the opening for stress relief.
    Type: Application
    Filed: August 20, 2018
    Publication date: February 20, 2020
    Applicant: CISCO TECHNOLOGY, INC.
    Inventors: Qirong Lin, George Edward Curtis, Ki-Yuen Chau, Quan Lu, Xiaogang Li
  • Patent number: 10559004
    Abstract: The present disclosure relates to a computer system configured establish and utilize a database for online ad realization prediction in an ad display platform associated with N parties, wherein N is a positive integral greater than 1. The computer system is configured obtain a party hierarchy for each of the N parties including a plurality of features of the party; select a target ad display event including N features, each of the N features corresponding to a node in a party hierarchy; obtain a prior probability reflecting an unconditional probability of ad realization occurrence at the target ad display event among all possible ad display events; for each of the N features: determine a marginal prior probability by decomposing components associated with the other N?1 features from the prior probability; determine a marginal posterior probability based on the marginal prior probability; and save the marginal posterior probability in the corresponding node of the party hierarchy.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: February 11, 2020
    Assignee: Oath Inc.
    Inventors: Hongxia Yang, Robert Ormandi, Han-Yun Tsao, Quan Lu
  • Patent number: 10547128
    Abstract: In one embodiment, an eye of needle (EON) press-fit pin includes a base, a tip, and a compliant portion extending longitudinally between the base and the tip and comprising a pair of resilient deformable arms joined at opposite ends and defining an opening therebetween. The arms each include an outer surface for at least partial engagement with walls of an electrical via upon insertion therein. The outer surface of each of the arms includes a central segment having a flat longitudinal surface and converges from the central segment towards the base and the tip. The arms each further include an inner surface defining the opening and forming an elongated portion at each end of the opening for stress relief.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: January 28, 2020
    Assignee: CISCO TECHNOLOGY, INC.
    Inventors: Qirong Lin, George Edward Curtis, Ki-Yuen Chau, Quan Lu, Xiaogang Li
  • Patent number: 10467313
    Abstract: To maximize the accuracy and efficiency of predicting users that will enjoy targeted content, a proposed content selection solution looks to combine a first strategy of utilizing selection rules with a second strategy of utilizing machine based learning models. By combining the selection rules-based approach and the machine learning model-based approach, the proposed content selection solution is able to consider and recommend a wider range of users for each available content.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: November 5, 2019
    Assignee: Oath Inc.
    Inventors: Liang Wang, Shengjun Pan, Kuang-chih Lee, Quan Lu, Junwei Pan
  • Publication number: 20190241876
    Abstract: Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.
    Type: Application
    Filed: April 12, 2019
    Publication date: August 8, 2019
    Applicants: President and Fellows of Harvard College, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Quan Lu, Qiyu Wang, Stanley N. Cohen