Abstract: Disclosed is a substrate processing method, which comprises the following steps: S1: transferring a substrate plated with a first metal layer from a first plating chamber to a second plating chamber; S2: after transferring the substrate to the second plating chamber, forming a water film layer on the front side of the substrate; S3: electroplating a second metal layer on the first metal layer. By means of a step of forming a water film layer before electroplating in a plating chamber, the present invention has advantages of preventing delamination between two metal layers and solving product recess abnormality.

Abstract: The present disclosure provides a display substrate, which includes a base substrate (101), a first power supply line (321a), a plurality of first signal leads (341), a plurality of test connection traces (342), at least one first connection line (381), and a plurality of test signal access pins (361). At least one first signal lead (341) is electrically connected to at least one test signal access pin (361) through at least one test connection trace (342). The first connection line (381) is located at a side of the plurality of test connection traces (342) and the plurality of test signal access pins (361) close to an edge of the peripheral area in a first direction (X). The first connection line (381) at least extends along a second direction (Y) and is electrically connected to the first power supply line (321a).

Abstract: A multi-focus histotripsy method based on a pulsed ultrasound phased array with hundred elements is provided. Excitation amplitude and phase of individual elements are regulated to control a phased array to produce multiple focus modes. A two-stage histotripsy is performed based on these focus modes. In a first stage, a first pulsed ultrasound is applied to an experimental sample in a target area to induce generation of cavitation microbubbles and boiling bubbles to preliminarily homogenize the experimental sample to form a loose product; and in a second stage, the experimental sample is mechanically disrupted and homogenized using a second pulsed ultrasound. The first pulsed ultrasound and the second pulsed ultrasound each are a hundred micro-second pulse or a milli-second pulse. Duty cycles of the first pulsed ultrasound and the second pulsed ultrasound are 3-10% and less than 2%, respectively. A multi-focus histotripsy system is further provided.

Abstract: A method for preparing a nano spherical oxide dispersion strengthening phase using a micron oxide is proposed for the first time. First, a micron oxide is used as a raw material to prepare a nano oxide with a completely amorphous structure/matrix alloy composite powder by mechanical ball milling in stages. In the first stage, ball milling is performed, causing the oxide to break and transform in structure, and achieving nano-sizing and completely amorphization, to prepare a composite powder with a completely amorphous structure nano oxide uniformly distributed in the matrix alloy powder; and in the second stage, the composite powder obtained in the first stage and the remaining matrix alloy powder are uniformly mixed by ball milling. Then, the uniformly mixed powder is sequentially subjected to hot forming, hot rolling, and heat treatment, to obtain a nano spherical oxide dispersion strengthened alloy.

Abstract: A hydraulic system for a rotary implement, including an oil tank, a main pump, a control valve, and a rotary motor is provided. The oil tank is connected to an oil suction port of the main pump; an oil outlet of the main pump is connected to a P port of the control valve; a T port of the control valve is interconnected with the oil tank; and A and B ports of the control valve are connected to both ends of the rotary motor. The control valve includes a compensation valve connected to the P port and the T port, an electric proportional valve connected to the P port and the compensation valve, and an electromagnetic reversing valve connected to the compensation valve, the T port and the B port.

Abstract: The present disclosure provides a to-be-evaporated substrate, a display substrate and a method of manufacturing a display substrate. The to-be-evaporated substrate may include: a substrate including a to-be-evaporated region and a non-evaporated region, where the non-evaporated region surrounds the to-be-evaporated region; a support pattern, disposed on the substrate and located in the non-evaporated region, where the support pattern includes a plurality of supporters for supporting a mask and further includes a first symmetrical pattern formed by a plurality of supporters, and the plurality of supporters forming the first symmetrical pattern are arranged along a perimeter of the to-be-evaporated region. The present disclosure can improve evaporation effect.

Abstract: Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.

Abstract: The present disclosure provides a domain dictionary constructing method and apparatus, the method including: segmenting a domain corpus sample to obtain a first character segment set, where the first character segment set includes at least one first character segment; calculating an inter-character correlation index of the at least one first character segment; determining a second character segment set according to the correlation index, where the second character segment set includes a first character segment of which the correlation index is greater than or equal to a preset threshold; determining a third character segment set according to the second character segment set, where the third character segment set includes the second character segment set and second character segments of the domain corpus; constructing a domain dictionary according to the third character segment set.

Abstract: The drive backplane includes a pixel area and a control area outside the pixel area. The control area includes a circuit area and a bus area between the circuit area and the pixel area. The drive backplane includes a substrate and a circuit layer provided on a side of the substrate. The circuit layer includes a plurality of pixel circuits, a plurality of gate lines, a gate drive circuit, bus lines, and a plurality of gate connection lines.

Abstract: An electric drive system with heat management includes an electric drive unit coupled with a battery system and a power conversion system. An energy storage unit contains at least one phase change material and is configured to manage thermal energy. A cooling system is configured to exchange heat and has a fluid system extending through the drive unit, the battery system, the power conversion system, the energy storage unit, and the cooling system. The fluid system configured to collect heat from the drive unit, the battery system and the power conversion system; selectively expel the heat through the cooling system; selectively store the heat in the energy storage unit in the at least one phase change material; and selectively supply heat from the energy storage unit to the battery system.

Abstract: Multi-chip module packaging technologies for GaN and other devices are described. The power module packaging technology described can be applied to all types of medium-voltage devices, such as silicon (Si), silicon carbide (SiC), gallium nitride (GaN), or the latest gallium oxide (Ga2O3) devices. In one example, a power module includes a first substrate, a second substrate, a sintered-silver semiconductor die pillar, the pillar being positioned between the first substrate and the second substrate, a terminal on a first side of the power module, and a terminal on a second side of the power module.

Abstract: Planar, double-side cooled half-bridge power modules using sintered-silver interposers and all sintered-silver joints are described. Thermo-mechanical simulations showed that use of the sintered-silver interposers reduce the thermo-mechanical stresses at vulnerable interfaces as compared to using solid copper interposers. The porous sintered-silver interposers are also easily deformable under a low load, which improves the yield of module interconnections in the presence of imperfections caused by variations in die thickness, interposer height, and substrate distortion. Results on the electrical performance of the modules validate the fabrication approach for the modules, for making high power-density converters with reliable operations at high junction temperatures.

Abstract: Methods, systems, compositions and strategies for the delivery of RNA into cells in vivo, ex vivo, or in vitro via ARMMs are provided. In some aspects, ARMMs containing fusion proteins of ARRDC1 fused to an RNA binding protein or an RNA binding protein fused to a WW domain are provided. In some aspects, ARMMs containing binding RNAs associated with cargo RNAs are provided. In other aspects, cargo RNAs associated with a binding RNA, such as a TAR element, are loaded into ARMMs via ARRDC1 fusion proteins containing an RNA binding protein, such as trans-activator of transcription (Tat) protein.

Abstract: Disclosed herein are methods, systems, compositions and strategies for the creation and use WW-domain-Activated Extracellular Vesicles, or WAEVs. These WAEVs can be harnessed to deliver and present viral or bacterial antigens useful for vaccine development; to display homing molecules for targeted delivery of therapeutic molecules to specific cells or tissues; and for packaging and delivery of therapeutic molecules via interactions with the WW domains.

Abstract: Disclosed herein are methods, systems, compositions and strategies for the creation and use WW-domain-Activated Extracellular Vesicles (WAEVs) for presenting HIV antigen domains. These WAEVs can be harnessed to deliver and present HIV antigens useful for vaccine development. Specifically, the disclosure provides a fusion protein comprising: (a) a WW-containing domain; (b) a transmembrane domain; and (c) an extracellular domain, wherein the extracellular domain is an HIV antigen domain. Further provided are sequences of each domain as well as methods of producing and using the fusion protein.

Abstract: Disclosed herein are methods, systems, compositions and strategies for the creation and use WW-domain-Activated Extracellular Vesicles, or WAEVs for presenting SARS-CoV-2 antigen domains, for example the SARS-CoV-2 M protein, the SARS-CoV-2 E protein, or the SARS-CoV-2 S protein. These WAEVs can be harnessed to deliver and present SARS-CoV-2 antigens useful for vaccine development.

Abstract: Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.

Abstract: Methods, systems, compositions and strategies for the delivery of RNA into cells in vivo, ex vivo, or in vitro via ARMMs are provided. In some aspects, ARMMs containing fusion proteins of ARRDC1 fused to an RNA binding protein or an RNA binding protein fused to a WW domain are provided. In some aspects, ARMMs containing binding RNAs associated with cargo RNAs are provided. In other aspects, cargo RNAs associated with a binding RNA, such as a TAR element, are loaded into ARMMs via ARRDC1 fusion proteins containing an RNA binding protein, such as trans-activator of transcription (Tat) protein.

Abstract: Methods, systems, compositions and strategies for the use of ARMM-mediated delivery of molecules (e.g., biological molecules, small molecules, proteins, and nucleic acids (e.g., DNA, RNA), DNA plasmids shRNA, mRNA) to cells of the nervous system (e.g., central nervous system and peripheral nervous system).

Abstract: Disclosed herein are minimal arrestin domain containing protein 1 (ARRDC1) constructs, which drive the formation of ARRDC1-mediated microvesicles (ARMMs). These vesicles can be harnessed to package and deliver a variety of molecular cargos such as small molecules, nucleic acids, and proteins. An example of such cargo is the genome editor Cas9.