Abstract: The disclosure relates to devices, systems and methods for image registration and annotation. The devices include computer software products for aligning whole slide digital images on a common grid and transferring annotations from one aligned image to another aligned image on the basis of matching tissue structure. The systems include computer-implemented systems such as work stations and networked computers for accomplishing the tissue-structure based image registration and cross-image annotation. The methods include processes for aligning digital images corresponding to adjacent tissue sections on a common grid based on tissue structure, and transferring annotations from one of the adjacent tissue images to another of the adjacent tissue images.

Abstract: Systems and methods for analyzing vessels in multiplexed images include detecting large vessels using a spoke feature detection method, detecting long and narrow vessels using a line feature detection method, detecting smaller vessels using rolling-ball filtering and binary image operations to generate a mask, and evaluating any contour polygons resulting from these operations using quality measurements and other thresholds. Maturity determination and nuclei detection are also performed, resulting in an output of vessel characteristics and co-locations enabling enhanced analysis of multispectral images.

Abstract: A method of generating recommended items for a current user in an unfamiliar domain includes selecting a reference user in a reference domain different from the unfamiliar domain, where current user behavior in the reference domain and reference user behavior in the reference domain have a user similarity index which satisfies a user similarity index condition. The method further includes generating the recommended items in the unfamiliar domain for the current user according to history behavior data of the reference user in the unfamiliar domain.

Abstract: The present invention relates to epitope peptides (or mutants thereof) for treating hepatitis B virus infection, recombinant proteins comprising such epitope peptides (or mutants thereof) and carrier proteins, and uses of such epitope peptides (or mutants thereof) and recombinant proteins. The present invention also relates to antibodies against such epitope peptides, cell lines producing said antibodies, and uses thereof. Furthermore, the present invention relates to vaccines or pharmaceutical compositions for treating or alleviating one or more symptoms associated with hepatitis B virus infection, which comprise the recombinant proteins or antibodies according to the invention, respectively.

Abstract: A method of setting up a polymerase chain reaction (“PCR”) includes providing a loading device configured to receive sample tubes for setting up a PCR; providing a tube holding device comprising at least a first receiving opening; attaching the tube holding device to the loading device; and aligning at least one receiving opening of the tube holding device with one of the first and second receiving openings of the loading device and simultaneously covering the other of the first and the second receiving openings of the loading device.

Abstract: A unit for processing a liquid/gas phase mixture, a mercaptan oxidation apparatus, and a method of processing a liquid/gas phase mixture are provided. In an embodiment, a unit for processing a liquid/gas phase mixture includes a vessel that is adapted to receive the liquid/gas phase mixture and a distributor that is disposed in the vessel. The distributor is adapted for flow of the liquid/gas phase mixture into the vessel, and the distributor includes a first outlet pipe that is horizontally disposed within the vessel. The first outlet pipe includes top orifices and bottom orifices that are spaced along the first outlet pipe, and the first outlet pipe is in fluid communication with the vessel through the top orifices and the bottom orifices. The top orifices have a smaller cross-sectional area than the bottom orifices.

Abstract: Disclosed herein are protein kinase inhibitors, more particularly pyridazine derivatives and pharmaceutical compositions thereof, and method of use thereof.

Abstract: A method for identifying biomarker-positive tumor cells is disclosed. The method includes, for example, reading a first digital image and a second digital image into memory, the first and second digital image depicting the same area of a first slide; identifying a plurality of nuclei and positional information of said nuclei by analyzing the light intensities in the first digital image; identifying cell membranes which comprise the biomarker by analyzing the light intensities in the second digital image and by analyzing the positional information of the identified nuclei; and identifying biomarker-positive tumor cells in said area, wherein a biomarker-positive tumor cell is a combination of one identified nucleus and one identified cell membrane that surrounds the identified nucleus.

Abstract: Apparatus and methods related to umbilical bend-testing are described. For example, some embodiments may contain a three-level support structure, umbilical terminal locker, bending machine, compression testing device, and stress-strain collection system, and may be used for the bending fatigue endurance test for umbilical samples.

Abstract: A baffle is installed on the wall of a regenerator vessel to push catalyst away from the wall to ensure adequate exposure to regeneration gas and complete combustion of coke from the catalyst. We have found that in deep beds, catalyst can flow down the walls and escape sufficient exposure to regeneration gas and undergo too little regeneration.

Abstract: Systems and methods for speeding up a spectral unmixing process by using pixel groups are disclosed. Operations including forming groups of similar pixels, and unmixing only one representative pixel from each pixel group enable determination of an unmixing result for all the pixels in the group. A similarity metric may be based on a dot product of an unprocessed pixel with the representative pixel in the subset of pixels. The method is repeated for any number of remaining unmatched pixels that exceed a threshold, until the number of remaining or unmatched pixels is smaller than the threshold, upon which the remaining pixels may be individually unmixed. Significantly fewer unmixing operations are performed on an image, thereby speeding up the unmixing process.

Abstract: Disclosed herein are protein kinase inhibitors, more particularly pyridazine derivatives and pharmaceutical compositions thereof, and method of use thereof.

Abstract: An apparatus for a fired heater is presented. The fired heater is designed with process coils inside a shell, and with a positioning of the burners for reducing the size of the fired heater. The shell has a general rectangular prismatic shape with combustion inlets for admitting combustion gases from the burners, and the process coils include at least two inlet ports and at least one outlet port.

Abstract: A fired heater is provided with u-shaped coils is provided. The coils have at least one inlet, at least one inlet section, at least one outlet and at least one outlet section. Burners are provided in both the center of the end wall of the fired heater and on the floor of the side wall. The fired heater is more compact and provides more even heat distribution compared to prior art heaters.

Abstract: The disclosure relates to devices, systems and methods for image registration and annotation. The devices include computer software products for aligning whole slide digital images on a common grid and transferring annotations from one aligned image to another aligned image on the basis of matching tissue structure. The systems include computer-implemented systems such as work stations and networked computers for accomplishing the tissue-structure based image registration and cross-image annotation. The methods include processes for aligning digital images corresponding to adjacent tissue sections on a common grid based on tissue structure, and transferring annotations from one of the adjacent tissue images to another of the adjacent tissue images.

Abstract: A segmented-centralized-type high-density electrical method measurement system and use thereof including a testing host, a plurality of electrode switching devices, a plurality of cables with taps, and a plurality of electrodes connected to the taps. By using this segmented-centralized-type high-density electrical measurement system, compared with a centralized-type high-density electrical measurement system, the required cable taps are less, the required cable weight is lower, not only resistivity test can be supported, but also induced polarization test, which is not supported by the centralized-type system, can be supported, the maximum transmitting current is larger, and rolling test can be supported; compared with a distributed-type high-density electrical measurement system, the cable diameter is smaller, the maximum transmitting current is larger, the cable weight is lighter, the cables are low-cost and durable, and because the cables can be replaced individually, their maintenance cost is low.

Abstract: The present disclosure provides a detailed description of techniques used in systems, methods, and in computer program products for bi-directional social media broker services that connect multiple social media sites using a common management framework. The claimed embodiments address the problem of efficiently scaling and managing bidirectional interaction with multiple social media publishing channels. More specifically, the claimed embodiments are directed to approaches for a computing platform having multiple message broker modules that enable bi-directional communication of messages between a common resource manager and a plurality of social media sites. The message broker modules can receive messages in a unified message format from the common resource manager, queue the messages for asynchronous processing, translate the messages from the unified message format to a site-specific format, and deliver the translated messages to multiple social media sites.

Abstract: An apparatus for use in radial flow reactors is presented. The apparatus includes a first partition and a second partition with support members coupled therebetween. The first partition include a first opening and a second opening to allow the passage of fluid therethrough. A baffle extends into a flow channel formed by adjacent support members to obstruct an upper or lower portion of the first opening to interrupt a portion of the fluid flow therethrough.

Abstract: Apparatus and methods related to fatigue testing are described. For example, some embodiments may contain a terminal fixer, a terminal support, a bending machine, and a stress-strain collector, and may be used for testing fatigue properties of offshore pipes, risers and their connectors. Some embodiments may be used to apply extruding, twisting and high frequency bending to the testing sample during one testing period, so that the various fatigue properties of the testing sample can be obtained.

Abstract: Disclosed herein are protein kinase inhibitors, more particularly pyridazine derivatives and pharmaceutical compositions thereof, and method of use thereof.