Patents by Inventor Quanhai Liu
Quanhai Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11866458Abstract: The invention discloses a panaxadiol glycoside derivative and a preparation method and application thereof. Such compounds show strong anti-inflammatory effects in vitro and in animal model experiments, and thus can be used to prepare anti-inflammatory drugs, especially can be used for treating asthma and COPD. In the experiment, the above-mentioned compounds have obvious effects on asthma and COPD, and the efficacy of the high-dose group is superior than that of dexamethasone and budesonide. Even under the dose much exceeding the therapeutic dose, no obvious affect on blood routine and blood glucoseis observed. It has high industrial prospects in the field of anti-inflammatory drugs, especially in the field for treating asthma and COPD.Type: GrantFiled: July 15, 2019Date of Patent: January 9, 2024Assignee: Suzhou JI ER Biological Medicine Co. Ltd.Inventors: Quanhai Liu, Jun Zhang
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Publication number: 20210054019Abstract: The invention discloses a panaxadiol glycoside derivative and a preparation method and application thereof. Such compounds show strong anti-inflammatory effects in vitro and in animal model experiments, and thus can be used to prepare anti-inflammatory drugs, especially can be used for treating asthma and COPD. In the experiment, the above-mentioned compounds have obvious effects on asthma and COPD, and the efficacy of the high-dose group is superior than that of dexamethasone and budesonide. Even under the dose much exceeding the therapeutic dose, no obvious affect on blood routine and blood glucoseis observed. It has high industrial prospects in the field of anti-inflammatory drugs, especially in the field for treating asthma and COPD.Type: ApplicationFiled: July 15, 2019Publication date: February 25, 2021Applicant: SUZHOU JI ER BIOLOGICAL MEDICINE CO., LTD.Inventors: QUANHAI LIU, JUN ZHANG
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Patent number: 10800733Abstract: Disclosed are a compound represented by Formula I or a pharmaceutically acceptable salt thereof, a preparation method therefor, the Formula I, and an application thereof in preparing drugs for regulating blood lipids.Type: GrantFiled: March 15, 2018Date of Patent: October 13, 2020Assignee: Shanghai Bioenergy Medicine Science & Technology Co., Ltd.Inventors: Yuqiong Dong, Quanhai Liu, Yu Shen, Wentao Cai
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Patent number: 10647673Abstract: Disclosed is a compound represented by formula I or a pharmaceutically acceptable salt thereof, preparation method thereof, and use thereof in preventing or treating fatty liver or in preparing pharmaceuticals for weight loss.Type: GrantFiled: March 15, 2018Date of Patent: May 12, 2020Assignee: Nanjing Bioenergy Medicine Science & Technology Co., Ltd.Inventors: Yuqiong Dong, Quanhai Liu, Yu Shen, Wentao Cai
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Patent number: 10428013Abstract: Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.Type: GrantFiled: June 25, 2012Date of Patent: October 1, 2019Assignees: Shanghai Institute of Phamaceutical Industry, China State Institute of Pharmaceutical IndustryInventors: Zhenpeng Yu, Gouping Wang, Zhen Zhang, Minyu Liu, Xiaoling Huang, Ying Liu, Lin Xiao, Li Cai, Xuejun Wu, Yifang Deng, Mianli Pan, Renhai Chen, Shenrong Tang, Quanhai Liu
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Publication number: 20190292153Abstract: Disclosed is a compound represented by formula I or a pharmaceutically acceptable salt thereof, preparation method thereof, and use thereof in preventing or treating fatty liver or in preparing pharmaceuticals for weight loss.Type: ApplicationFiled: March 15, 2018Publication date: September 26, 2019Applicant: Nanjing Bioenergy Medicine Science & Technology Co., Ltd.Inventors: Yuqiong DONG, Quanhai LIU, Yu SHEN, Wentao CAI
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Publication number: 20190292137Abstract: Disclosed are a compound represented by Formula I or a pharmaceutically acceptable salt thereof, a preparation method therefor, the Formula I, and an application thereof in preparing drugs for regulating blood lipids.Type: ApplicationFiled: March 15, 2018Publication date: September 26, 2019Applicant: Shanghai Bioenergy Medicine Science & Technology Co., Ltd.Inventors: Yuqiong DONG, Quanhai LIU, Yu SHEN, Wentao CAI
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Patent number: 10238657Abstract: Disclosed herein is a method of treating psoriasis involving the use of compound of formula I and/or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 3, 2015Date of Patent: March 26, 2019Assignee: JS INNOPHARM (SHANHAI) LTD.Inventors: Jintao Zhang, Quanhai Liu, Minyu Liu, Xiaoling Huang, Yifang Deng, Pengxia Yu
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Publication number: 20180169096Abstract: Disclosed herein is a method of treating psoriasis involving the use of compound of formula I and/or a pharmaceutically acceptable salt thereofType: ApplicationFiled: June 3, 2015Publication date: June 21, 2018Applicant: JS INNOPHARM (SHANGHAI) LTD.Inventors: Jintao ZHANG, Quanhai LIU, Minyu LIU, Xiaoling HUANG, Yifang DENG, Pengxia YU
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Patent number: 9650403Abstract: Disclosed are a platinum (II) compound, a preparation method therefor, and a pharmaceutical composition and an application thereof. The preparation method comprises the following steps: enabling dihydrate diammine platinum nitrate (4) to react with the carboxylate ligand derivative (5) in water, to produce a platinum (II) compound. Also provided are an application of the platinum (II) compound in preparation of an antitumor drug, and a pharmaceutical composition. The pharmaceutical composition contains an active component and a medicinal carrier, the active component containing the platinum (II) compound, and the mass percentage of the active component being 0.1%-95%. The platinum (II) compound of the present invention is well water-soluble, low toxic, easily prepared, and efficient in antitumor activity.Type: GrantFiled: March 19, 2014Date of Patent: May 16, 2017Assignees: SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY, CHINA STATE INSTITUTE OF PHARMACEUTICAL INDUSTRYInventors: Baoquan Zhu, Yongzhi Shu, Jun Lin, Haifeng Hu, Quanhai Liu, Bin Zhou
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Patent number: 9539271Abstract: The present invention discloses an application of depolymerized holothurian glycosaminoglycans (DHG) in preparation of a drug for the prevention and treatment of thromboembolic diseases. The DHG is more than one type of DHG with weight-average molecular weights between 26,000 and 45,000 Da. When being intravenously or subcutaneously injected, the drug using the DHG with weight-average molecular weights between 26,000 and 45,000 Da as an active ingredient has a significant anticoagulant effect, while at the same time, has little side effects, and is effective for use in the prevention and treatment of the thromboembolic diseases. For an injection of DHG with weight-average molecular weights between 26,000 Da and 45,000 Da, the blood coagulation time is prolonged and the anticoagulant effect is enhanced as the dosage increases; the subcutaneous administration is used and is more favorable for use in the drug, and the convenience and safety of use the drug are improved.Type: GrantFiled: March 1, 2013Date of Patent: January 10, 2017Assignees: Shanghai Kairun Biology Medicine Limited Liability Company, Harbin Hongdoushan Bio-Pharm Co., Ltd., Heilongjiang Hongdoushan Pharmaceutical Co., Ltd.Inventors: Zhiguo Wang, Quanhai Liu, Xuehai Wu
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Publication number: 20160194345Abstract: Disclosed are a platinum (II) compound, a preparation method therefor, and a pharmaceutical composition and an application thereof. The preparation method comprises the following steps: enabling dihydrate diammine platinum nitrate (4) to react with the carboxylate ligand derivative (5) in water, to produce a platinum (II) compound. Also provided are an application of the platinum (II) compound in preparation of an antitumor drug, and a pharmaceutical composition. The pharmaceutical composition contains an active component and a medicinal carrier, the active component containing the platinum (II) compound, and the mass percentage of the active component being 0.1%-95%. The platinum (II) compound of the present invention is well water-soluble, low toxic, easily prepared, and efficient in antitumor activity.Type: ApplicationFiled: March 19, 2014Publication date: July 7, 2016Applicants: SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY, CHINA STATE INSTITUTE OF PHARMACEUTICAL INDUSTRYInventors: Baoquan ZHU, Yongzhi SHU, Jun LIN, Haifeng HU, Quanhai LIU, Bin ZHOU
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Publication number: 20160082051Abstract: The present invention discloses use of sea cucumber glycosaminoglycan in the preparation of drugs. In particular, the present invention relates to use of medical use of sea cucumber glycosaminoglycan, and more particularly to use of depolymerized sea cucumber glycosaminoglycan or natural molecular segments of sea cucumber glycosaminoglycan with a weight average molecular weight greater than 54,500 Da in the preparation of a drug for the prevention and treatment of thromboembolic diseases. Thromboembolic diseases include atherosclerotic thrombotic diseases, venous thromboembolic diseases, hypercoagulable states and postoperative thrombosis or treatment of postoperative thrombi. The present invention has a wide treatment window for thromboembolic diseases, has a higher level of safety, and has good development and research value.Type: ApplicationFiled: May 7, 2014Publication date: March 24, 2016Applicants: Shanghai Kairun Biology Medicine Limited Liability Company, Harbin Hongdoushan Bio-Pharm Co., Ltd., Heilongjiang Hongdoushan Pharmaceutical Co., Ltd.Inventors: Zhiguo Wang, Quanhai Liu, Xuehai Wu
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Patent number: 8962880Abstract: An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.Type: GrantFiled: March 21, 2012Date of Patent: February 24, 2015Assignee: Shanghai Institute of Pharmaceutical IndustryInventors: Guobin Ren, Ying Liu, Jinyao Chen, Xiaoling Huang, Lin Xiao, Li Cai, Zhen Zhang, Xuejun Wu, Haiyan Sun, Quanhai Liu, Liling Jin, Minyu Liu, Yifang Deng, Zhiru Xu, Renhai Chen, Chungang Li, Xiangduan Tan, Yan Qin
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Publication number: 20150051165Abstract: The present invention discloses an application of depolymerized holothurian glycosaminoglycans (DHG) in preparation of a drug for the prevention and treatment of thromboembolic diseases. The DHG is more than one type of DHG with weight-average molecular weights between 26,000 and 45,000 Da. When being intravenously or subcutaneously injected, the drug using the DHG with weight-average molecular weights between 26,000 and 45,000 Da as an active ingredient has a significant anticoagulant effect, while at the same time, has little side effects, and is effective for use in the prevention and treatment of the thromboembolic diseases. For an injection of DHG with weight-average molecular weights between 26,000 Da and 45,000 Da, the blood coagulation time is prolonged and the anticoagulant effect is enhanced as the dosage increases; the subcutaneous administration is used and is more favorable for use in the drug, and the convenience and safety of use the drug are improved.Type: ApplicationFiled: March 1, 2013Publication date: February 19, 2015Applicants: Shanghai Kairun Biology Medicine Limited Liability Company, Harbin Hongdoushan Bio-Pharm Co., Ltd., Heilongjiang Hongdoushan Pharmaceutical Co., LtdInventors: Zhiguo Wang, Quanhai Liu, Xuehai Wu
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Publication number: 20140243553Abstract: An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.Type: ApplicationFiled: March 21, 2012Publication date: August 28, 2014Applicant: SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRYInventors: Guobin Ren, Ying Liu, Jinyao Chen, Xiaoling Huang, Lin Xiao, Li Cai, Zhen Zhang, Xuejun Wu, Haiyan Sun, Quanhai Liu, Liling Jin, Minyu Liu, Yifang Deng, Zhiru Xu, Renhai Chen, Chungang Li, Xiangduan Tan, Yan Qin
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Patent number: 8742167Abstract: A highly pure asiaticoside and a pharmaceutical grade asiatic acid can be prepared, along with salts of asiatic acid, for use in formulating therapeutic compositions that are suitable for treating arthritis, psoriasis and other inflammatory diseases, as well as pulmonary fibrosis, diabetic nephropathy, and other fibrotic diseases.Type: GrantFiled: January 8, 2009Date of Patent: June 3, 2014Assignee: Shanghai Institute of Pharmaceutical IndustryInventors: Ying Liu, Quanhai Liu, Yan Qin, Tong Wu, Zhiru Xu, Min-yu Liu, Fei Li, Yan Li, Michael J. Newman
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Publication number: 20140128463Abstract: Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.Type: ApplicationFiled: June 25, 2012Publication date: May 8, 2014Applicants: China State Institute of Pharmaceutic Industry, Shanghai Institute of Pharmaceutical IndustryInventors: Zhenpeng Yu, Gouping Wang, Zhen Zhang, Minyu Liu, Xiaoling Huang, Ying Liu, Lin Xiao, Li Cai, Xuejun Wu, Yifang Deng, Mianli Pan, Renhai Chen, Shenrong Tang, Quanhai Liu
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Patent number: 8258176Abstract: The invention discloses a dithiolopyrrolone compound represented by formula I or its pharmaceutically acceptable salts, wherein X1, R1, R2, R3, R4 are defined as in the description. The invention also discloses the preparation of such compounds, and the use of such compounds in preparation of medicaments for increasing peripheral white blood cells and in preparation of ancillary medicaments for inhibiting the decrease of peripheral white blood cells in radiotherapy or chemotherapy.Type: GrantFiled: August 29, 2008Date of Patent: September 4, 2012Assignees: Shanghai Institute of Pharmaceutical Industry, Shanghai Modern Pharmaceutical Co., Ltd.Inventors: Guoping Wang, Quanhai Liu, Haiyan Sun, Wei Wu, Jian Hou, Lin Yao, Chungang Li, Minyu Liu, Fei Li, Xuejun Wu, Shuai Zhao
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Publication number: 20100331413Abstract: A highly pure asiaticoside and a pharmaceutical grade asiatic acid can be prepared, along with salts of asiatic acid, for use in formulating therapeutic compositions that are suitable for treating arthritis, psoriasis and other inflammatory diseases, as well as pulmonary fibrosis, diabetic nephropathy, and other fibrotic diseases.Type: ApplicationFiled: January 8, 2009Publication date: December 30, 2010Inventors: Ying Liu, Quanhai Liu, Yan Qin, Tong Wu, Zhiru Xu, Min-yu Liu, Fei Li, Yan Li, Michael J. Newman