Patents by Inventor Quanjiang JI

Quanjiang JI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250188451
    Abstract: The present invention relates to the field of biomedicine and discloses a use of a C2C9 nuclease as an RNA-guided endonuclease, and a small sized genome editing system. The genome editing system comprises a C2C9 nuclease and/or a nucleic acid encoding the C2C9 nuclease, and a guide RNA or a nucleic acid encoding the guide RNA. The small sized genome editing system of the present invention can perform gene editing on at least one target sequence in a genome of prokaryotic bacteria and eukaryotic cells. The present invention also discloses a use of the genome editing system and an editing method. By using the genome editing system or method of the present invention, a target gene can be precisely knocked out or cut off, the cutting efficiency is high, and precise editing of the target gene is implemented.
    Type: Application
    Filed: November 17, 2022
    Publication date: June 12, 2025
    Applicant: ShanghaiTech University
    Inventors: Quanjiang JI, Weizhong CHEN, Jiacheng MA
  • Publication number: 20230212612
    Abstract: Provided is a genome editing system and method for gene editing at least one target sequence in a cell genome. The genome editing system comprises: (1) an expression construct comprising a Cas12f nuclease; and (2) an expression DNA sequence comprising a guide RNA corresponding to the Cas12f nuclease, and an expression construct of the targeting sequence of the target sequence. The gene editing system or method can accurately knock out a target gene from within a cell; in addition, in an in vitro cutting experiment, the target gene can be accurately cut.
    Type: Application
    Filed: November 30, 2020
    Publication date: July 6, 2023
    Inventors: Quanjiang JI, Zhaowei WU, Yifei ZHANG, Yujue WANG, Yannan WANG