Patents by Inventor Quet Fah Ahkong

Quet Fah Ahkong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of temperature to control the size of cationic liposome/plasmid DNA complexes
    Patent number: 5965542
    Abstract: Methods of forming cationic liposome/nucleic acid complexes in which the complexes have a mean diameter of about 200 to about 300 nm are provided. The complexes are formed by combining a first solution of preformed cationic unilamellar liposomes with a mean diameter of from 100 to 150 nm, with a second solution of nucleic acid. Each of the solutions are equilibrated prior to mixing to temperatures of from 0.degree. C. to about 12.degree. C., preferably about 2.degree. C. to about 7.degree. C. The preformed cationic liposomes are typically prepared from an unsaturated cationic lipid, for example DODAC, DOTAP, DOTMA, DODAP, DMRIE, DORI, DOSPA and combinations thereof, and a neutral lipid, for example DOPE or cholesterol. The combination of the first and second solutions is typically carried out by gentle mixing over ice for a period of time of from about 10 to about 60 minutes.
    Type: Grant
    Filed: March 18, 1997
    Date of Patent: October 12, 1999
    Assignee: Inex Pharmaceuticals Corp.
    Inventors: Ellen K. Wasan, Marcel B. Bally, Michael J. Hope, Dorothy L. Reimer, Quet Fah Ahkong