Patents by Inventor QUINLAN SIEVERS

QUINLAN SIEVERS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of characterizing resistance to modulators of Cereblon
    Patent number: 11459613
    Abstract: In one aspect, the present invention features method of identifying a cell resistant to a modulator of Cereblon (CRBN). In another aspect, the present invention features a method of characterizing sensitivity of a subject to a modulator of CRBN. In yet another aspect, the present invention features a method of monitoring sensitivity of a subject to a modulator of CRBN.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: October 4, 2022
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Benjamin Levine Ebert, Quinlan Sievers
  • METHODS OF CHARACTERIZING RESISTANCE TO MODULATORS OF CEREBLON
    Publication number: 20220251651
    Abstract: In one aspect, the present invention features method of identifying a cell resistant to a modulator of Cereblon (CRBN). In another aspect, the present invention features a method of characterizing sensitivity of a subject to a modulator of CRBN. In yet another aspect, the present invention features a method of monitoring sensitivity of a subject to a modulator of CRBN.
    Type: Application
    Filed: September 9, 2016
    Publication date: August 11, 2022
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: BENJAMIN LEVINE EBERT, QUINLAN SIEVERS
  • METHODS OF IDENTIFYING DRUG-MODULATED POLYPEPTIDE TARGETS FOR DEGRADATION
    Publication number: 20220017938
    Abstract: In one aspect, the invention features a method for identifying a drug-modulated polypeptide substrate of cereblon (CRBN). In another aspect, the invention features a method of identifying a polypeptide target of a modulator of CRBN. In yet another aspect, the invention provides methods of monitoring or characterizing the sensitivity of a subject to a modulator of CRBN.
    Type: Application
    Filed: October 7, 2021
    Publication date: January 20, 2022
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: TARJEI MIKKELSEN, BENJAMIN LEVINE EBERT, QUINLAN SIEVERS
  • Methods of identifying a polypeptide target for degradation by a modulator of CRBN
    Patent number: 11168345
    Abstract: In one aspect, the invention features a method for identifying a drug-modulated polypeptide substrate of cereblon (CRBN). In another aspect, the invention features a method of identifying a polypeptide target of a modulator of CRBN. In yet another aspect, the invention provides methods of monitoring or characterizing the sensitivity of a subject to a modulator of CRBN.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: November 9, 2021
    Assignees: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Tarjei Mikkelsen, Benjamin Levine Ebert, Quinlan Sievers
  • METHODS OF IDENTIFYING DRUG-MODULATED POLYPEPTIDE TARGETS FOR DEGRADATION
    Publication number: 20190071731
    Abstract: In one aspect, the invention features a method for identifying a drug-modulated polypeptide substrate of cereblon (CRBN). In another aspect, the invention features a method of identifying a polypeptide target of a modulator of CRBN. In yet another aspect, the invention provides methods of monitoring or characterizing the sensitivity of a subject to a modulator of CRBN.
    Type: Application
    Filed: September 9, 2016
    Publication date: March 7, 2019
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: TARJEI MIKKELSEN, BENJAMIN LEVINE EBERT, QUINLAN SIEVERS