Abstract: A bilateral biosensor based upon a microporous architecture is provided which seeks to reduce the effect of co-reactant concentration limitations by utilizing a new sensor microgeometry. If implemented on the appropriate scale, the new sensor design augments substantially the concentration of oxygen, or other co-reactants or reagents, in the reaction zone of the sensor. Performance enhancements over traditional microscale devices employing unilateral orientation are accomplished, in one embodiment, by allowing analyte to enter the sensor from one side of the sensor, while allowing a co-substrate to enter from both sides of the sensor.