Patents by Inventor Quinton Norman WESSELLS

Quinton Norman WESSELLS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENE EDITING SYSTEMS COMPRISING AN RNA GUIDE TARGETING LACTATE DEHYDROGENASE A (LDHA) AND USES THEREOF
    Publication number: 20230034581
    Abstract: Provided herein are gene editing systems and/or compositions comprising RNA guides targeting LDHA for use in genetic editing of the LDHA gene. Also provide herein are methods of using the gene editing system for introducing edits to the LDHA gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.
    Type: Application
    Filed: June 3, 2022
    Publication date: February 2, 2023
    Inventors: Quinton Norman WESSELLS, Jeffrey Raymond HASWELL, Tia Marie DITOMMASO, Noah Michael JAKIMO, Sejuti SENGUPTA
  • GENE EDITING SYSTEMS COMPRISING AN RNA GUIDE TARGETING TRANSTHYRETIN (TTR) AND USES THEREOF
    Publication number: 20220396782
    Abstract: A system for genetic editing of a transthyretin (TTR) gene, comprising (i) a Cas12i2 polypeptide or a first nucleic acid encoding the Cas12i2 polypeptide, and (ii) an RNA guide or a second nucleic acid encoding the RNA guide, wherein the RNA guide comprises a spacer sequence specific to a target sequence within an TTR gene. Also provided herein are methods for editing a TTR gene using the gene editing system disclosed herein and/or for treating diseases associated with the TTR gene.
    Type: Application
    Filed: June 3, 2022
    Publication date: December 15, 2022
    Inventors: Quinton Norman WESSELLS, Jeffrey Raymond HASWELL, Tia Marie DITOMMASO, Noah Michael JAKIMO, Sejuti SENGUPTA