Abstract: Computer systems and associated methods are disclosed to detect a future change point in time series data used as input to a machine learning model. A forecast for the time series data is generated. In some embodiments, a fitting model is generated from the time series data, and residuals of the fitting model are obtained for respective portions of the data both before and after a potential change point in the future. The change point is determined based on a ratio of residual metrics for the two portions. In some embodiments, data features are extracted from individual segments in the time series data, and the segments are clustered based on their data features. A change point is determined based on a dissimilarity in cluster assignments for segments before and after the point. In some embodiments, when a change point is predicted, an update of the machine learning model is triggered.

Abstract: The invention disclosed the use of timosaponin BII in the preparation of a medicament or product for the prevention and treatment of stroke. The experiments prove that timosaponin BII can improve the neurological symptoms of cerebral ischemic rat, reduce infarct size, relieve brain water edema, improve hemorheology, reduce inflammatory injury of cerebral ischemia.

Abstract: The invention disclosed the use of timosaponin BII in the preparation of a medicament or product for the prevention and treatment of stroke. The experiments prove that timosaponin BII can improve the neurological symptoms of cerebral ischemic rat, reduce infarct size, relieve brain water edema, improve hemorheology, reduce inflammatory injury of cerebral ischemia.