Abstract: Use of immune checkpoint inhibitors in combination with anti-aging drugs in tumor treatment and tumor treatment products are disclosed, which provides a new drug and treatment strategy for effective treatment of tumors. The therapeutic effect of the provided treatment of ICIs in combination with the anti-aging drug is superior to that of the current treatment of ICIs treatment alone, and ICIs in combination with chemotherapy, etc. In the action process of ICIs in combination with the anti-aging drug, aging cells can be selectively removed, the aging state of an immune system thus is reversed. Accordingly, the inhibitory effect of tumor on the immune micro-environment is reduced, thus improving the treatment effect on various solid tumors. Based on the use or product provided by the present invention, new strategies and new ideas can be provided for further improving the clinical efficacy and prognosis of the solid tumors.

Abstract: This invention discloses a bend insensitive single mode fiber, which is composed by a bare glass fiber with a round cross section and two resin protective layers with circular cross sections surrounding the outer of the bare glass fiber. It is characterized in that the bare glass fiber is composed by a core layer with a round cross section and two claddings with circular cross sections. The refractive index of the core layer is higher than the index of the two claddings and the refractive index difference between the core layer and the first cladding is larger than the difference between the first and second claddings. The second cladding is made of pure SiO2. The refractive index profile of the core layer follows a power function, and the refractive index profile of the two claddings follow a ladder-type distribution. The loss of the invented fiber is insensitive to the bending of the fiber, which meets the requirements of ITU.T G.657.A and G.657.B standards, respectively.

Abstract: This invention discloses a bend insensitive single mode fiber, which is composed by a bare glass fiber with a round cross section and two resin protective layers with circular cross sections surrounding the outer of the bare glass fiber. It is characterized in that the bare glass fiber is composed by a core layer with a round cross section and two claddings with circular cross sections. The refractive index of the core layer is higher than the index of the two claddings and the refractive index difference between the core layer and the first cladding is larger than the difference between the first and second claddings. The second cladding is made of pure SiO2. The refractive index profile of the core layer follows a power function, and the refractive index profile of the two claddings follow a ladder-type distribution. The loss of the invented fiber is insensitive to the bending of the fiber, which meets the requirements of ITU.T G.657.A and G.657.B standards, respectively.