Patents by Inventor Qunying Dai

Qunying Dai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS
    Publication number: 20150158809
    Abstract: Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.
    Type: Application
    Filed: February 25, 2014
    Publication date: June 11, 2015
    Applicant: XENOPORT, INC.
    Inventors: Huan Wang, Peng Liu, Qunying Dai, Hao Yin, Stephen P. Raillard
  • METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS
    Publication number: 20140243544
    Abstract: Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.
    Type: Application
    Filed: February 25, 2014
    Publication date: August 28, 2014
    Applicant: XENOPORT, INC.
    Inventors: Huan Wang, Peng Liu, Qunying Dai, Hao Yin, Stephen P. Raillard
  • Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
    Patent number: 8299291
    Abstract: The present disclosure relates to methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs and to intermediates used in the methods.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: October 30, 2012
    Assignees: XenoPort, Inc., Glaxo Group Limited
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Peng Liu, Qunying Dai, Hao Yin
  • Methods of synthesizing -hydroxysuccinimidyl carbonates
    Patent number: 7989641
    Abstract: The present disclosure relates to methods of synthesizing N-hydroxysuccinimidyl-carbonate intermediates from the corresponding sulfones useful in the preparation of 1-(acyloxy)-alkyl carbamate prodrugs.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: August 2, 2011
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Peng Liu, Qunying Dai, Hao Yin
  • Carvedilol salts, corresponding compositions, methods of delivery and/or treatment
    Patent number: 7750036
    Abstract: The present invention relates to a salt of carvedilol and/or corresponding solvates thereof, compositions containing such carvedilol and/or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to carvedilol phosphate salts, and/or solvates thereof, which include a novel crystalline form of carvedilol dihydrogen phosphate (i.e., which is the dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.) and/or other corresponding solvates thereof, compositions containing these carvedilol phosphate salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: July 6, 2010
    Assignee: SB Pharmco Puerto Rico Inc.
    Inventors: Christopher S. Brook, Pingyun Y. Chen, Wei Chen, Qunying Dai, Philip C. Dell'Orco, Clifford S. Labaw, Ann Marie Diederich, Choon K. Oh, Claire Hisler, David H. Igo, Lee M. Katrincic, Li-Jen Ping, Paul G. Spoors, Jun Wang, Christopher Werner
  • METHODS OF SYNTHESIZING 1-(ACYLOXY)-ALKYL CARBAMATE PRODRUGS
    Publication number: 20100087667
    Abstract: The present disclosure relates to methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs and to intermediates used in the methods.
    Type: Application
    Filed: August 7, 2009
    Publication date: April 8, 2010
    Applicants: XenoPort, Inc., Glaxo Group Limited
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Peng Liu, Qunying Dai, Hao Yin
  • METHODS OF SYNTHESIZING N-HYDROXYSUCCINIMIDYL CARBONATES
    Publication number: 20100081830
    Abstract: The present disclosure relates to methods of synthesizing N-hydroxysuccinimidyl-carbonate intermediates from the corresponding sulfones useful in the preparation of 1-(acyloxy)-alkyl carbamate prodrugs.
    Type: Application
    Filed: August 7, 2009
    Publication date: April 1, 2010
    Applicants: XenoPort, Inc., Glaxo Group Limited
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Peng Liu, Qunying Dai, Hao Yin
  • Carvedilol hydrobromide
    Patent number: 7649010
    Abstract: The present invention relates to a salt of carvedilol, corresponding compositions containing such a carvedilol salt or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to a novel crystalline form of carvedilol hydrobromide, which is the hydrobromide salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol, and/or other carvedilol solvates thereof, compositions containing salts or solvates of carvedilol hydrobromide, and methods of using the aforementioned compound(s) to treat hypertension, congestive heart failure, and angina, etc.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: January 19, 2010
    Assignee: SmithKline Beechman Cork Limited
    Inventors: Pingyun Y. Chen, Qunying Dai, Philip C. Dell'Orco, Claire Hisler, David H. Igo, Lee M. Katrincic, Clifford S. Labaw, Li-Jen J. Ping
  • Method of Preparation of Benzofuran-2-Carboxylic Acid -Amide
    Publication number: 20080262224
    Abstract: This invention relates to a method of preparation of benzofuran-2-carboxylic acid {(S)-3-methyl-1-[(4S,7R)-7-methyl-3-oxo-1-(pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}-amide.
    Type: Application
    Filed: January 21, 2005
    Publication date: October 23, 2008
    Inventors: William M. Clark, Neil Francis Badham, Qunying Dai, Ann Marie Eldridge, Hayao Matsuhashi
  • Carvedilol Hydrobromide
    Publication number: 20070142451
    Abstract: The present invention relates to a salt of carvedilol, corresponding compositions containing such a carvedilol salt or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to a novel crystalline form of carvedilol hydrobromide, which is the hydrobromide salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol, and/or other carvedilol solvates thereof, compositions containing salts or solvates of carvedilol hydrobromide, and methods of using the aforementioned compound(s) to treat hypertension, congestive heart failure, and angina, etc.
    Type: Application
    Filed: October 11, 2006
    Publication date: June 21, 2007
    Inventors: Pingyun Chen, Qunying Dai, Philip Dell'Orco, Claire Hisler, David Igo, Lee Katrincic, Clifford Labaw, Li-Jen Ping
  • Carvedilol salts, corresponding compositions, methods of delivery and/or treatment
    Publication number: 20050277689
    Abstract: The present invention relates to a salt of carvedilol and/or corresponding solvates thereof, compositions containing such carvedilol and/or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to carvedilol phosphate salts, and/or solvates thereof, which include a novel crystalline form of carvedilol dihydrogen phosphate (i.e., which is the dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.) and/or other corresponding solvates thereof, compositions containing these carvedilol phosphate salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
    Type: Application
    Filed: November 24, 2004
    Publication date: December 15, 2005
    Inventors: Christopher Brook, Pingyun Chen, Wei Chen, Qunying Dai, Philip Dell'Orco, Clifford Labaw, Ann Diederich, Choon Oh, Claire Hisler, David Igo, Lee Katrincic, Li-Jen Ping, Paul Spoors, Jun Wang, Christopher Werner
  • Carvedilol hydobromide
    Publication number: 20050261355
    Abstract: The present invention relates to a salt of carvedilol, corresponding compositions containing such a carvedilol salt or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to a novel crystalline form of carvedilol hydrobromide, which is the hydrobromide salt of 1-(carbazol-4-yloxy)-3-[[2-(omethoxyphenoxyl)ethyl]amino]-2-propanol, and/or other carvedilol solvates thereof, compositions containing salts or solvates of carvedilol hydrobromide, and methods of using the aforementioned compound(s) to treat hypertension, congestive heart failure, and angina, etc.
    Type: Application
    Filed: June 27, 2003
    Publication date: November 24, 2005
    Applicant: SB Pharmco Puerto Rico Inc.,
    Inventors: Pingyun Chen, Qunying Dai, Philip Cell'Orco, Claire Hisler, David Igo, Lee Katrincic, Clifford Labaw, Li-Jen Ping