Patents by Inventor Quynh Thu Le

Quynh Thu Le has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for increasing proliferation of adult salivary stem cells
    Patent number: 10457659
    Abstract: The present disclosure provides methods of increasing proliferation of adult salivary stem cells. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with an aldehyde dehydrogenase (ALDH) agonist. Increasing proliferation of adult salivary stem cells can be carried out to provide for an increase in the number of adult salivary stem cells in an individual undergoing radiotherapy for head and neck cancer.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: October 29, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Che-Hong Chen, Daria Mochly-Rosen, Quynh-Thu Le
  • MONOTERPENE ACTIVATORS OF ALDEHYDE DEHYDROGENASE 3A1 AND METHODS OF USE THEREOF
    Publication number: 20190060249
    Abstract: The present disclosure provides methods of increasing proliferation of adult salivary stem cells, methods of protecting adult salivary stem cells and improving salivary gland function. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with a therapeutically effective amount of at least one isolated monoterpene and subjecting the adult salivary stem cells to radiation treatment. Increasing proliferation of adult salivary stem cells can be carried out to provide for an increase in the number of adult salivary stem cells and improve salivary gland function in an individual undergoing radiotherapy for head and neck cancer. The methods also include treating an individual with dry eye with a therapeutically effective amount of at least one isolated monoterpene.
    Type: Application
    Filed: August 23, 2018
    Publication date: February 28, 2019
    Inventors: Julie Saiki, Che-Hong Chen, Quynh-Thu Le, Daria Mochly-Rosen
  • Compositions and Methods for Increasing Proliferation of Adult Salivary Stem Cells
    Publication number: 20140323520
    Abstract: The present disclosure provides methods of increasing proliferation of adult salivary stem cells. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with an aldehyde dehydrogenase (ALDH) agonist. Increasing proliferation of adult salivary stem cells can be carried out to provide for an increase in the number of adult salivary stem cells in an indi vidual undergoing radiotherapy for head and neck cancer.
    Type: Application
    Filed: April 26, 2012
    Publication date: October 30, 2014
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Che-Hong Chen, Daria Mochly-Rosen, Quynh-Thu Le
  • Diagnostic marker for tumor hypoxia and prognosis
    Publication number: 20030044862
    Abstract: Osteopontin (OPN) levels measured in bodily fluids of cancer patients are used as a noninvasive marker for tumor hypoxia as described herein. Methods of using OPN levels for the diagnosis, prognosis and treatment of cancers characterized by the presence of hypoxic cells, and a kit for detecting the presence of a hypoxic tumor are provided.
    Type: Application
    Filed: June 18, 2002
    Publication date: March 6, 2003
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY
    Inventors: Amato J. Giaccia, Quynh Thu Le, Nicholas C. Denko