Abstract: The present invention is directed to novel pyridizinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition.

Abstract: A method of determining the integrity of a gyro in a navigation system is provided. The method includes detecting a relatively sudden change in one of a pitch, yaw and roll signal from a respective pitch, yaw and roll gyro and reviewing at least one other of the pitch, yaw and roll signals to verify the relatively sudden change.

Abstract: A method of implementing a fault-tolerant-avionic architecture in a vehicle includes using parity logic to monitor the functionality of at least three non-fault-tolerant inertial measurement units during a parity check and calculating a threshold from expected inertial measurement unit performance during a parity check. If a failure of an inertial measurement unit is detected based on the calculated threshold, then the method further includes identifying the failed inertial measurement units based on a direction of a parity vector in parity space. Each inertial measurement unit comprises at least one triad of sensors.

Abstract: A peptide-chelate conjugate with affinity for the ST receptor is disclosed, wherein the chelate is tetradentate. The peptide-chelate conjugate of the invention may be labelled with a radiometal to provide a metal complex. A radiopharmaceutical composition comprising the metal complex is provided. which is suitable for the diagnostic imaging of colorectal cancer. Also provided for in the invention is a kit for the preparation of the radiopharmaceutical preparation.

Abstract: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.

Abstract: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.

Abstract: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.

Abstract: A method of implementing a fault-tolerant-avionic architecture in a vehicle includes using parity logic to monitor the functionality of at least three non-fault-tolerant inertial measurement units during a parity check and calculating a threshold from expected inertial measurement unit performance during a parity check. If a failure of an inertial measurement unit is detected based on the calculated threshold, then the method further includes identifying the failed inertial measurement units based on a direction of a parity vector in parity space.

Abstract: Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.

Abstract: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.

Abstract: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.

Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.

Abstract: A method of controlling, reducing, or eliminating microorganisms including, but not limited to, fungi and bacteria associated with hygiene, food spoilage, and human pathogenesis on food surfaces after the foods have been packaged is achieved by exposing the microorganisms to a source of pulsed ultraviolet radiation through transmissible packaging. The duration of the pulses of ultraviolet radiation are in the range of picoseconds to microseconds at about 1 mJ/cm2 to about 10 J/cm2. Total energy irradiance is controlled in the case of foods with limited tolerance to such exposure.

Abstract: Systems and methods for providing telephone service to transient or inaccessible customers include a stationary cellular telephone that operates like a land-line telephone in that its use is restricted to a single geographic area, such a house address. The stationary cellular telephone can only handoff between cell sites that are associated with the geographic area. The stationary cellular telephone can place calls using only cell sites in a list of permissible cell sites that is maintained at the network level. The stationary cellular telephone is activated by sending customer, device, and/or location identifiers to an activation center via a telephone call. The activation center validates service, and downloads the list of permissible cell sites to the stationary cellular telephone. Dynamic rates provide opportunities for further reduction in the cost of service, with real-time notification of capacity based pricing, and service levels that vary according to network capacity.

Abstract: Systems and methods for controlling traffic on a communications network include dynamic and flexible control plans that enable service providers to control or influence customer access to communications facilities. Communications facilities are monitored to identify network elements, such as cell sites, that are overloaded. When the traffic intensity on a particular facility exceeds a predetermined level, either active or passive control is imposed on subscribers that are in the geographic area of the facility. Active control involves blocking, delaying or disrupting subscriber calls during the critical time period. Passive control involves providing cost incentives or disincentives during low or peak periods of traffic intensity. Customers are notified of the commencement and/or termination of active or passive control preferably via SMS.

Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.

Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.

Abstract: Systems and methods for controlling traffic on a communications network include dynamic and flexible control plans that enable service providers to control or influence customer access to communications facilities. Communications facilities are monitored to identify network elements, such as cell sites, that are overloaded. When the traffic intensity on a particular facility exceeds a predetermined level, either active or passive control is imposed on subscribers that are in the geographic area of the facility. Active control involves blocking, delaying or disrupting subscriber calls during the critical time period. Passive control involves providing cost incentives or disincentives during low or peak periods of traffic intensity. Customers are notified of the commencement and/or termination of active or passive control preferably via SMS.

Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.