Patents by Inventor R. Bleackley

R. Bleackley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for and methods of granzyme B inhibition
    Publication number: 20070104699
    Abstract: The present invention is related to the discovery that serpina3n, a secreted protein, binds to and inhibits granzyme B activity. The invention thus provides cells that include a polynucleotide encoding a granzyme B inhibitory serpin, pharmaceutical compositions including a granzyme B inhibitory serpin or a polynucleotide encoding a granzyme B inhibitory serpin, methods for treating a patient in need of immunosuppression by administration of a granzyme B inhibitory serpin, and methods of transplanting cells (e.g., islet cells) expressing a granzyme B inhibitory serpin.
    Type: Application
    Filed: September 26, 2006
    Publication date: May 10, 2007
    Applicant: University of Alberta
    Inventors: Ray Rajotte, R. Bleackley, Greg Korbutt, Sarah Lord, Simonetta Sipione, Katia Carmine-Simmen, Fabrizio Giuliani