Patents by Inventor R. Clark Billinghurst

R. Clark Billinghurst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoassays for the measurement of collagen denaturation and cleavage in cartilage
    Patent number: 6132976
    Abstract: The present invention relates to a method for detecting cartilage degradation in a biological sample by identifying the presence of unwound type II collagen in the biological sample, said method comprising:contacting the biological sample with a monoclonal antibody which does not bind to native helical collagen but which does bind to an epitope on unwound type II collagen chains or fragments thereof, wherein said epitope has the following sequence (SEQ ID NO: 4):A-P(OH)-G-E-D-G-R-P(OH)-G-P-P(OH)-G-P; anddetecting the presence of the bound monoclonal antibody.
    Type: Grant
    Filed: January 22, 1998
    Date of Patent: October 17, 2000
    Assignee: Shriners Hospitals for Children
    Inventors: Anthony Robin Poole, Anthony Peter Hollander, R. Clark Billinghurst