Patents by Inventor R. Clark Brown

R. Clark Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biological extracts and method for making same
    Patent number: 4376819
    Abstract: A p-nitrophenyl hydrolase contaminant present in Limulus coagulase sources interferes in, i.e., inhibits, coagulase-based assays for endotoxin. The contaminant inhibitor enzyme may be removed from coagulase by physical separation or by selective denaturation, for example by adjusting the pH of a coagulase solution to about from 8.5 to 11. Inhibitor-free coagulase is a novel composition. The coagulase activity of the composition is adjusted to a predetermined level to provide a standardized coagulase reagent for use in endotoxin assays.
    Type: Grant
    Filed: February 23, 1981
    Date of Patent: March 15, 1983
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: R. Clark Brown, Richard Cotter, Susan K. Young