Abstract: The present invention discloses compounds and methods used to specifically target substrates of methylation by S-adenosyl-L-methionine (SAM)-dependent methyltransferases. The substrates can be peptides, single stranded nucleic acids or double stranded nucleic acids, including RNA, DNA and PNA or phospholipids. The compounds disclosed are SAM analogs that are ligated to a methylation site by the methyltransferase. Also disclosed, are reacting groups that are ligatable to the cofactor analogs and can also be used as detectable labels. The reacting group can be used to cleave the substrate providing a methylation footprint. The invention can be used clinically to determine methylation state of a gene or gene promoter such as those involved in imprinting and transcription. In some preferred embodiments, the invention includes a kit, which can include one or more suitable SAM analogs and may include one or more detectable labels. In other preferred embodiments, the invention includes a pharmaceutical composition.

Abstract: Compounds, compositions and methods for modulating cell death in target cells, particularly cancer cells are provided. The compounds are analogs of O-acetyl-ADP-ribose (OAADPr).

Abstract: A protective glove/wrist guard device is provided that prevents hands from slipping out from under a falling ice skater when the ice skater extends his or her hands to break a fall. The protective glove/wrist guard device may include a palm surface portion having a high-friction surface portion, to provide both high-friction when contacting ice, and wrist support to help prevent wrist and hand injuries. Alternatively, the protective device may be in the form of a glove with a high friction material disposed on a palm surface portion of the glove.

Abstract: Apparatus for repeatedly indicating incremental pressure fluctuations and methods employing same are disclosed. A chamber may be sealed at an initial pressure and configured to respond to a pressure difference between the initial pressure and subsequent pressure within a container. The container may be filled via a valve mechanism exhibiting a first operational state that may allow for entry of material into the container while sealing the chamber at the initial pressure of the container as it began to be filled. A movable element communicating with the sealed chamber and the container may respond to a pressure differential therebetween, thus causing an indicator to indicate an incremental pressure fluctuation. The valve mechanism may exhibit a second operating state that may allow for the chamber and container pressures to be substantially equalized.

Abstract: Apparatus for repeatedly indicating incremental pressure fluctuations and methods employing same are disclosed. A chamber may be sealed at an initial pressure and configured to respond to a pressure difference between the initial pressure and subsequent pressure within a container. The container may be filled via a valve mechanism exhibiting a first operational state that may allow for entry of material into the container while sealing the chamber at the initial pressure of the container as it began to be filled. A movable element communicating with the sealed chamber and the container may respond to a pressure differential therebetween, thus causing an indicator to indicate an incremental pressure fluctuation. The valve mechanism may exhibit a second operating state that may allow for the chamber and container pressures to be substantially equalized.

Abstract: An identification record for an animal (human, livestock, game, companion/pets, etc.) is created by gathering/collecting biometric information (such as, extracting information from an image acquired of the retinal vasculature of the animal of interest) and pairing it with geographic data received. A biometric measurement results in information such as audio data, visual data, a description of the animal, birth date, death date, cause of death, genetic breeding data, production data, veterinary/medical records, data pertaining to a vaccination event, feed formulas, feedlot locations, border crossings, shipping data, data pertaining to current ownership and transfers in interest, livestock or range animal purchase information, a code or other designation assigned to the animal (whether digitally encrypted), a photo, image, or other graphic record of one or more features of the animal, microchip implant data implanted (for example, tagging, insertion, embedding, impressing, and injection), and so on.

Abstract: The present invention creates a permanent record of an animal through a series of steps including, preliminarily acquiring an image of the retinal vasculature of the animal of interest; digitizing that image if the image is not a digital image; analyzing the image to determine if the image is satisfactory for further analysis; storing the image; and analyzing the image for unique anatomical landmarks. The image and data gathered therefrom may be stored in a database for later retrieval and comparison against other images. The data gathered from the image may be compared against other stored data in the database to determine the identity of the animal. Preferably, the system would also include a global positioning system (“GPS”) device which would simultaneously time and date stamp the acquired image as well as stamp the image with the location where the imaging took place by recording the latitude and longitude of that location.

Abstract: The present invention creates a permanent record of an animal through a series of steps including, preliminarily acquiring an image of the retinal vasculature of the animal of interest; digitizing that image if the image is not a digital image; analyzing the image to determine if the image is satisfactory for further analysis; storing the image; and analyzing the image for unique anatomical landmarks. The image and data gathered therefrom may be stored in a database for later retrieval and comparison against other images. The data gathered from the image may be compared against other stored data in the database to determine the identity of the animal. Preferably, the system would also include a global positioning system (“GPS”) device which would simultaneously time and date stamp the acquired image as well as stamp the image with the location where the imaging took place by recording the latitude and longitude of that location.

Abstract: In accordance with embodiments of the invention, Mobile IP binding information is used to deliver mobile terminating packets using layer-2 tunneling. When terminating packets destined for a mobile node are received by a home network for the mobile node, the Mobile IP binding is used to obtain the address of a foreign network to which the mobile node is attached. A Layer 2 Tunneling Protocol tunnel is created between the home network and the foreign network, and an outgoing L2TP call is made from the home network to the foreign network. A call is made from the foreign network to the mobile node, and a PPP session is established between the home network and the mobile node, via the Layer 2 Tunneling Protocol tunnel between the home network and the foreign network. After the PPP session is established the home network can optionally assign the mobile node a private IP address, and translate the home IP address labeling the terminating packets to the private IP address.

Abstract: The disclosure of this application is directed to unsaturated polyester compositions, containing as a low-profile additive a carboxyl containing thermoplastic polymer of a vinyl ester of an aliphatic, saturated monocarboxylic acid, which have particular utility in molding applications to form aesthetically attractive thermoset articles characterized by excellent physical properties, as for example, impact strength and by excellent surface properties such as excellent smoothness and gloss, excellent receptiveness to paints and excellent reproduction of the surface contours of the mold in which they are formed into shaped, thermoset articles.

Abstract: The disclosure of this application is directed to unsaturated polyester compositions, containing a thermoplastic terpolymer of a vinyl halide monomer, a vinyl ester of a saturated, monocarboxylic acid and as the third component, an unsaturated, dicarboxylic acid or anhydride thereof; or as the third component, a glycidyl ester of an unsaturated, monocarboxylic acid, which can be pigmented with organic and/or inorganic pigments and molded into shaped, thermoset articles such as housings for telephones, automobile heater ducts and the like which are characterized by excellent surface characteristics and color properties.

Abstract: An accessory for use with a conventional door closer having a body for mounting on a hinged door or the door jamb and a spring biased rotatable shaft constantly urging the door toward a closed position. The accessory comprises a first member having a reaction plate fixed with respect to the door closer body, a second member, such as an externally splined ring, fixed with respect to the door closer shaft, and a member, such as a flanged collar, rotatably interconnecting the first and second members. The collar is threaded into a hole in the reaction plate, and has an internally splined hole accommodating and meshing with the splined ring. The force of frictional engagement between the flange and the reaction plate progressively increases as the door is opened, and at an adjustable predetermined open position of the door the frictional resistance between the flange and reaction plate is stronger than the closing force of the door closer, so that the door is held open.

Abstract: The disclosure of this application is directed to unsaturated polyester compositions, containing as a low-profile additive a carboxyl containing thermoplastic polymer of a vinyl ester of an aliphatic, saturated monocarboxylic acid, which have particular utility in molding applications to form aesthetically attractive thermoset articles characterized by excellent physical properties, as for example, impact strength and by excellent surface properties such as excellent smoothness and gloss, excellent receptiveness to paints and excellent reproduction of the surface contours of the mold in which they are formed into shaped, thermoset articles.