Abstract: An apparatus for imaging an eye includes a housing and a system of optical components disposed in the housing. The apparatus is capable of operating in a line scanning laser opthalmoscope (LSLO) mode and an optical coherence tomography (OCT) mode. The system of optical components can include a first source to provide a first beam of light for the OCT mode and a second source to provide a second beam of light for the LSLO mode. In the OCT mode, a first optic is used that (i) scans, using a first surface of the first optic, the first beam of light along a retina of an eye in a first dimension, and (ii) descans, using the first surface, a first light returning from the eye in the first dimension to a detection system in the OCT mode. In the LSLO mode, the first optic is used where the second beam of light passes through a second surface of the first optic.

Abstract: An apparatus for imaging an eye includes a housing and a system of optical components disposed in the housing. The apparatus is capable of operating in a line scanning laser ophthalmoscope (LSLO) mode and an optical coherence tomography (OCT) mode. The system of optical components can include a first source to provide a first beam of light for the OCT mode and a second source to provide a second beam of light for the LSLO mode. In the OCT mode, a first optic is used that (i) scans, using a first surface of the first optic, the first beam of light along a retina of an eye in a first dimension, and (ii) descans, using the first surface, a first light returning from the eye in the first dimension to a detection system in the OCT mode. In the LSLO mode, the first optic is used where the second beam of light passes through a second surface of the first optic.

Abstract: Real time, high-speed image stabilization with a retinal tracking scanning laser ophthalmoscope (TSLO) enables new approaches to established diagnostics. Large frequency range (DC to 19 kHz), wide-field (40-deg) stabilized Doppler flowmetry imaging is described for human subjects. The fundus imaging method is a quasi-confocal line-scanning laser ophthalmoscope (LSLO). The retinal tracking system uses a confocal reflectometer with a closed loop optical servo system to lock onto features in the ocular fundus and automatically re-lock after blinks. By performing a slow scan with the laser line imager, frequency-resolved retinal perfusion and vascular flow images can be obtained free of eye motion artifacts.

Abstract: Systems and methods for providing a line-scanning laser ophthalmoscope (LSLO) are disclosed. The LSLO uses a substantially point source of light, such as an infrared laser or a super-luminescent diode. The point source is expanded to a line. The LSLO scans the line of light in a direction perpendicular to the line across a region of an eye having an undilated pupil The reflected light is received confocally, using monostatic beam geometry. A beam separator, such as a turning prism or mirror, diverts one of the incoming light and the reflected light to separate the light. An optical stop prevents non-confocally received light from reaching a one-dimensional detector, such as a linear CCD array. An electrical signal responsive to the output light at each of a plurality of locations along the line of output light is processed to provide images of the scanned portion of the eye.

Abstract: Methods and apparatus for imaging a sample using a microwell array are provided. The methods and apparatus allow side view imaging of a sample to acquire fluorescence or bright field images.

Abstract: Systems and methods for providing a line-scanning laser ophthalmoscope (LSLO) are disclosed. The LSLO uses a substantially point source of light, such as an infrared laser or a super-luminescent diode. The point source is expanded to a line. The LSLO scans the line of light in a direction perpendicular to the line across a region of an eye having an undilated pupil The reflected light is received confocally, using monostatic beam geometry. A beam separator, such as a turning prism or mirror, diverts one of the incoming light and the reflected light to separate the light. An optical stop prevents non-confocally received light from reaching a one-dimensional detector, such as a linear CCD array. An electrical signal responsive to the output light at each of a plurality of locations along the line of output light is processed to provide images of the scanned portion of the eye.

Abstract: Systems and methods for providing a line-scanning laser ophthalmoscope (LSLO) are disclosed. The LSLO uses a substantially point source of light, such as an infrared laser or a super-luminescent diode. The point source is expanded to a line. The LSLO scans the line of light in a direction perpendicular to the line across a region of an eye having an undilated pupil The reflected light is received confocally, using monostatic beam geometry. A beam separator, such as a turning prism or mirror, diverts one of the incoming light and the reflected light to separate the light. An optical stop prevents non-confocally received light from reaching a one-dimensional detector, such as a linear CCD array. An electrical signal responsive to the output light at each of a plurality of locations along the line of output light is processed to provide images of the scanned portion of the eye.

Abstract: Apparatus and methods for tracking a feature on a target surface and continually providing analog corrections to tracking mirrors in real time by utilizing a low-power incoherent tracking beam to detect the movements of a reference feature on the target and confocal reflectometry to monitor the reflection from the tracking beam's current position are described.

Abstract: An homogenization valve design yields improved homogenization efficiency. The length of the valve surface relative to the valve seat or land is controlled so that the overlap is limited. This allows convergence between turbulent mixing layers and a homogenization zone. Preferably some overlap is provided, however, to contribute to the stability of the valves and avoid destructive chattering.

Abstract: Apparatus and methods for tracking a feature on a target surface and continually providing analog corrections to tracking mirrors in real time by utilizing a low-power incoherent tracking beam to detect the movements of a reference feature on the target and confocal reflectometry to monitor the reflection from the tracking beam's current position are described.

Abstract: An homogenization valve design yields improved homogenization efficiency. The length of the valve surface relative to the valve seat or land is controlled so that the overlap is limited. This allows convergence between turbulent mixing layers and a homogenization zone. Preferably some overlap is provided, however, to contribute to the stability of the valves and avoid destructive chattering.