Abstract: The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments.

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

Abstract: A three-dimensional inkjet printer and method for printing an aperture mask on a multi-spectral filter array. A custom tray is used by the printer allowing for printing on a prefabricated filter array. Photopolymer resin is deposited on the prefabricated filter array to form the aperture mask of dark mirror coating. An ultraviolet lamp illuminates the deposited photopolymer resin on the surface of the prefabricated multi-spectral optical filter array to cure the resin, thereby forming the mask. The prefabricated multi-spectral optical filter array includes an optical coating on at least one side, the aperture mask being formed on the optical coating, without the use of heat, chemical etching, or deformation of the optical coating.

Abstract: A three-dimensional inkjet printer and method for printing an aperture mask on a multi-spectral filter array. A custom tray is used by the printer allowing for printing on a prefabricated filter array. Photopolymer resin is deposited on the prefabricated filter array to form the aperture mask of dark mirror coating. An ultraviolet lamp illuminates the deposited photopolymer resin on the surface of the prefabricated multi-spectral optical filter array to cure the resin, thereby forming the mask. The prefabricated multi-spectral optical filter array includes an optical coating on at least one side, the aperture mask being formed on the optical coating, without the use of heat, chemical etching, or deformation of the optical coating.

Abstract: The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

Abstract: The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

Abstract: Optical filter elements each include a parallelogram-shaped substrate with parallel light entrance and light exit surfaces and parallel slanted sidewalls slanted at an angle, and an interference filter disposed on one or both of the light entrance surface and the light exit surface. The optical filter elements are bonded together at the slanted sidewalls to form the optical filter array. Light is filtered by illuminating the optical filter array at an angle ? equal to or corresponding to the angle of the slanted sidewalls. In some embodiments the angle of the slanted sidewalls corresponds to the angle-of-incidence ? by Snell's law.

Abstract: The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

Abstract: A method and apparatus for message cache sizing are provided. A plurality of messages from one or more enqueuers are enqueued in a queue comprising at least one shard. Each shard includes one or more subshards. A message cache configured to store a plurality of cached subshards is maintained in memory. The plurality of messages is dequeued from the message cache by one or more dequeuers. An estimated enqueue rate is determined for each shard. An estimated dequeue rate is determined for each dequeuer-shard pair. Estimated restore overhead data is determined over a range of candidate message cache sizes based on the estimated enqueue rate for each shard and the estimated dequeue rate for each dequeuer-shard pair. A preferred message cache size is determined based on the estimated restore overhead data.

Abstract: The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

Abstract: An apparatus is disclosed comprising an optical filter array including an array of optical filter elements; wherein each optical filter element has opposing mutually parallel principal faces connected by sidewalls including at least one pair of opposing trapezoidal sidewalls and at least one pair of opposing sidewalls that are not mutually parallel; and wherein the opposing mutually parallel principal faces of the filter elements collectively define optical entrance and exit apertures of the optical filter array and include interference filters. Further disclosed is a method of illuminating such a filter array.

Abstract: An apparatus is disclosed comprising an optical filter array including an array of optical filter elements; wherein each optical filter element has opposing mutually parallel principal faces connected by sidewalls including at least one pair of opposing trapezoidal sidewalls and at least one pair of opposing sidewalls that are not mutually parallel; and wherein the opposing mutually parallel principal faces of the filter elements collectively define optical entrance and exit apertures of the optical filter array and include interference filters. Further disclosed is a method of illuminating such a filter array.

Abstract: An apparatus is disclosed comprising an optical filter array including an array of optical filter elements; wherein each optical filter element has opposing mutually parallel principal faces connected by sidewalls including at least one pair of opposing trapezoidal sidewalls and at least one pair of opposing sidewalls that are not mutually parallel; and wherein the opposing mutually parallel principal faces of the filter elements collectively define optical entrance and exit apertures of the optical filter array and include interference filters. Further disclosed is a method of illuminating such a filter array.

Abstract: An apparatus for reducing or eliminating gas lock in a downhole pump is provided. The apparatus has a ported bushing connecting to an upper standing valve at a first, uphole end and connecting to a lower standing valve at a second, downhole end. The apparatus also has one or more vents. In one embodiment, the apparatus is coupled downhole of a traveling valve of a downhole pump such that, on each upstroke, the one or more vents of the apparatus draw liquid from the annulus between the pump and the tubing into the passage between the upper and lower standing valves for opening the upper standing valve to accumulate liquid in the pump barrel below the traveling valve. The accumulation of liquid in the pump barrel below the traveling valve breaks gas lock and opens the traveling valve, ensuring the operation of pumping liquid from downhole to surface.

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

Abstract: A three-dimensional inkjet printer and method for printing an aperture mask on a multi-spectral filter array. A custom tray is used by the printer allowing for printing on a prefabricated filter array. Photopolymer resin is deposited on the prefabricated filter array to form the aperture mask of dark mirror coating. An ultraviolet lamp illuminates the deposited photopolymer resin on the surface of the prefabricated multi-spectral optical filter array to cure the resin, thereby forming the mask. The prefabricated multi-spectral optical filter array includes an optical coating on at least one side, the aperture mask being formed on the optical coating, without the use of heat, chemical etching, or deformation of the optical coating.

Abstract: An apparatus (e.g., a multi-spectral optical filter array, an optical wafer, an optical component) has an aperture mask printed directly thereon, the aperture mask including a positive or negative photoresist. The apparatus includes a substrate having the aperture mask printed on at least one of a light entrance surface or a light exit surface of the substrate so as to provide an aperture over a portion of the substrate. The photoresist from which the aperture mask is formed is photo-definable or non-photo-definable, and is deposited/printed to form the aperture mask on the substrate.

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.