Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropatterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.

Abstract: A method and system for setting image analysis parameters to control image analysis operations. The method and system include collecting set of digital training images including a set of states for the set of digital training images. An objective function is defined to determine a relative quality of plural different parameter sets used for digital image analysis. Values for the plural different parameter sets that maximize (or minimize) the objective function are determined. The method and system increases a usability of high content screening technologies by reducing a required level of expertise required to configure digital image processing.

Abstract: A reconfigurable physical therapy apparatus and a method of providing operator-selected stimuli to a patient are provided. The apparatus preferably has a physical therapy applicator including a transducer for applying a therapeutic treatment to a patient, and a memory for storing identification data representative of a plurality of physical ailments for each of a plurality of human body areas and a set of transducer operational parameters associated with each predetermined physical ailment and each predetermined body area. The apparatus also has an ailment display screen responsive to the memory device for displaying at least one of the identification data representative of a plurality of physical ailments which are associated with at least one of the identified human body areas.