Abstract: A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9, and MMP-13, while exhibiting substantially less inhibition at least of MMP-1 to a host having a condition associated with pathological matrix metalloprotease activity. The administered enzyme inhibitor corresponds in structure to formula (I), below, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are both hydrido or R1 and R2 together with the atoms to which they are bonded form a 5- to 8-membered ring containing one, two, or three heteroatoms in the ring that are oxygen, sulfur, or nitrogen. R3 in formula (I) is an optionally substituted aryl or optionally substituted heteroaryl radical.

Abstract: A heat exchanger for heating or cooling objects is flexible and can conform to surface profiles of objects to be warmed or cooled. The heat exchanger has a volume having at least one inlet for receiving a heat exchange fluid and at least one outlet. A flexible plate essentially impermeable to the heat exchange fluid is penetrated by substantially rigid thermally conductive members. The members provide paths of high thermal conductivity through the plate. The heat exchange fluid may be water based.

Abstract: A flexible heat exchanger is suitable for heating or cooling living subjects. The heat exchanger has a a volume having at least one inlet for receiving a heat exchange fluid and at least one outlet. A flexible heat exchange plate that isessentially impermeable to the heat exchange fluid is penetrated by substantially rigid thermally conductive members. The members provide paths of high thermal conductivity through the plate. The heat exchange fluid may be water.

Abstract: The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.

Abstract: A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9, and MMP-13, while exhibiting substantially less inhibition at least of MMP-1 to a host having a condition associated with pathological matrix metalloprotease activity. The administered enzyme inhibitor corresponds in structure to formula (I), below, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are both hydrido or R1 and R2 together with the atoms to which they are bonded form a 5- to 8-membered ring containing one, two, or three heteroatoms in the ring that are oxygen, sulfur, or nitrogen. R3 in formula (I) is an optionally substituted aryl or optionally substituted heteroaryl radical.

Abstract: A coin mechanism has one or more coin tubes for storing, respectively, coins of one or more denominations, a dispenser for controlling the dispensing of coins from the coin tubes, and a coin mechanism controller suitable for connection to a controller in an automatic transaction system so as to receive change dispense signals from the automatic transaction system controller indicating the form of dispensing change to a customer. The coin mechanism controller, when connected to the automatic transaction system controller, serves as an interface between the automatic transaction system controller and the dispenser, and is programmed to re-determine the form of paying out the change, for example, by taking into account the distribution and denominations of the coins in the coin tubes. The arrangement of coin tubes in a coin tube cassette for use with the coin mechanism can be identified by entering a code on a keypad associated with the coin mechanism.

Abstract: A portable communication device uses a first electrostatic antenna element and a second electrostatic antenna element and circuitry which is coupled to the first antenna element and to the second antenna element and which derives operating power from an electrostatic field in the vicinity of the first and second antenna elements. The electrostatic field may be provided by an array of exciter elements containing both horizontal and vertical exciter elements so that at some point as a communication device is moved across the exciter antenna array, the device will have sufficient power coupled to it to power up and become operational.

Abstract: A safety holster for a firearm, including a pivotally mounted retaining member for engaging the trigger guard of the firearm and preventing withdrawal of the firearm from the holster by anyone other than an authorized user of the firearm. The holster includes a fingerprint sensor for scanning fingerprint information of a perspective user of the firearm, and a processor for comparing the scanned fingerprint information with stored fingerprint information of an authorized user and releasing the retaining member only if the scanned fingerprint information matches that of the authorized user.

Abstract: A multi-layer golf ball can be prepared, possessing the performance characteristics of both a solid ball and a wound ball, by selecting the content and thickness of one or more of the layers, wherein the multi-layer golf ball comprises a center, an intermediate layer, a wound layer of tensioned material, and a cover, such that any one or more of the following are satisfied: (a) at least a portion of the intermediate layer includes a thermoset material; (b) the winding includes fiber, glass, carbon, polyether urea, polyether block copolymers, polyester urea, polyester block copolymers, isotactic-poly(propylene), polyethylene, polyamide, poly(oxymethyiene), polyketone, poly(ethylene terephthalate), poly(p-phenylene terephthalamide), poly(acrylonitrile), diaminodicyclohexyhnethane, dodecanedicarboxylic acid, or copolymers or combinations thereof; (c) the thickness of the wound layer is less than about I mm; and (d) at least a portion of the cover includes a thermoset material.

Abstract: A digital Storage Element is described. A device is configured including a Storage Element for access by a user responsive to a native control code. A processing arrangement executes a control program for controlling the overall device and executing at least a portion of the native control code as part of the control program for interfacing with the Storage Element. A programming arrangement is provided separate from the device for customizing a read channel within the Storage Element. Command, user interaction and data transfer execution are discussed for mitigation of potential mechanical shock effects. Status indications relating to the Storage Element are provided including head position and mechanical shock. Calibration, test and operational monitoring procedures, for using head position status, are described. Failure configuration monitoring is provided in tracking overall performance and design considerations.

Abstract: A safety holster for a firearm, including two pivotally mounted retaining members that cooperate to engage the trigger guard of the firearm and prevent withdrawal of the firearm from the holster by anyone other than an authorized user of the firearm. The holster includes a fingerprint sensor for scanning fingerprint information of a perspective user of the firearm, and a processor for comparing the scanned fingerprint information with stored fingerprint information of an authorized user and releasing the retaining member only if the scanned fingerprint information matches that of the authorized user.

Abstract: A securing mechanism for use in a holster, gun safe, base station, recharging/docking station, gun rack, or other safety housing for a firearm or other item, including one or more retaining members that engage the trigger guard, barrel, or other part of the firearm to prevent withdrawal of the firearm from the safety housing by anyone other than an authorized user of the firearm. The securing mechanism includes a biometric identification mechanism such as a fingerprint sensor for scanning fingerprint information of a prospective user of the firearm, and a processor for comparing the scanned biometric information with stored biometric information of an authorized user and releasing the retaining member only if the scanned biometric information matches that of the authorized user.

Abstract: A multi-layer golf ball can be prepared, possessing the performance characteristics of both a solid ball and a wound ball, by selecting the content and thickness of one or more of the layers, wherein the multi-layer golf ball comprises a center, an intermediate layer, a wound layer of tensioned material, and a cover, such that any one or more of the following are satisfied: (a) at least a portion of the intermediate layer includes a thermoset material; (b) the winding includes fiber, glass, carbon, polyether urea, polyether block copolymers, polyester urea, polyester block copolymers, isotactic-poly(propylene), polyethylene, polyamide, poly(oxymethylene), polyketone, poly(ethylene terephthalate), poly(p-phenylene terephthalamide), poly(acrylonitrile), diaminodicyclohexylmethane, dodecanedicarboxylic acid, or copolymers or combinations thereof; (c) the thickness of the wound layer is less than about 1 mm; and (d) at least a portion of the cover includes a thermoset material.

Abstract: A multi-layer golf ball can be prepared, possessing the performance characteristics of both a solid ball and a wound ball, by selecting the content and thickness of one or more of the layers, wherein the multi-layer golf ball comprises a center, an intermediate layer, a wound layer of tensioned material, and a cover, such that any one or more of the following are satisfied: (a) at least a portion of the intermediate layer includes a thermoset material; (b) the winding includes fiber, glass, carbon, polyether urea, polyether block copolymers, polyester urea, polyester block copolymers, isotactic-poly(propylene), polyethylene, polyamide, poly(oxymethyiene), polyketone, poly(ethylene terephthalate), poly(p-phenylene terephthalamide), poly(acrylonitrile), diaminodicyclohexyhnethane, dodecanedicarboxylic acid, or copolymers or combinations thereof; (c) the thickness of the wound layer is less than about I mm; and (d) at least a portion of the cover includes a thermoset material.

Abstract: An integration messaging system for creating and processing customized business transactions between an originator and one or more subscribers connected to the integration messaging system via a common protocol or channel and wherein the originator selects a set of values associated with a set of data fields and associates a set of processes to a subset of the set of values. When the originator or one or more of the subscribers inserts data or changes data in one or more of the subset of the set of values, a processing device within the integration messaging system executes the customized business transaction according to one or more of the set of processes associated with the one or more of the subset of the set of values wherein data was inserted or changed.

Abstract: A safety holster for a firearm, including two pivotally mounted retaining members that cooperate to engage the trigger guard of the firearm and prevent withdrawal of the firearm from the holster by anyone other than an authorized user of the firearm. The holster includes a fingerprint sensor for scanning fingerprint information of a perspective user of the firearm, and a processor for comparing the scanned fingerprint information with stored fingerprint information of an authorized user and releasing the retaining member only if the scanned fingerprint information matches that of the authorized user.

Abstract: A safety holster for a firearm, including a pivotally mounted retaining member for engaging the trigger guard of the firearm and preventing withdrawal of the firearm from the holster by anyone other than an authorized user of the firearm. The holster includes a fingerprint sensor for scanning fingerprint information of a perspective user of the firearm, and a processor for comparing the scanned fingerprint information with stored fingerprint information of an authorized user and releasing the retaining member only if the scanned fingerprint information matches that of the authorized user.

Abstract: An automatic transaction machine bezel (150) for attachment to the front panel of the machine (1) that is durable and versatile, and that advantageously provides for at least two forms of payment is disclosed. The face (151) of the bezel fits through an industry-standard size opening in the front panel of the automatic transaction machine. In one embodiment, the bezel contains one aperture to accept banknotes, coins and cards in payment for a vend item.

Abstract: An exemplary embodiment of the invention is a system for detecting the status of a bill validator in a gaming device. The system includes a credit detector for receiving a signal from the gaming device and generating a credit detector signal indicating whether the gaming device has one or more credits. A bill validator enable detector receives a signal from the gaming device and generates a bill validator enable signal indicating the status of the bill validator. A coin lockout detector receives a signal from the gaming device and generates a coin lockout signal indicating whether the gaming device is ready for play. A logic unit generates an error signal indicative of a malfunction in the bill validator in response to the credit detector signal, the bill validator enable signal and the coin lockout signal.

Abstract: A safety holster for a firearm, including a pivotally mounted retaining member for engaging the trigger guard of the firearm and preventing withdrawal of the firearm from the holster by anyone other than an authorized user of the firearm. The holster includes a fingerprint sensor for scanning fingerprint information of a perspective user of the firearm, and a processor for comparing the scanned fingerprint information with stored fingerprint information of an authorized user and releasing the retaining member only if the scanned fingerprint information matches that of the authorized user.