Abstract: A device enables direct, continual analysis by mass spectrometry of one or more analytes in a complex liquid sample. A first sprayer nebulizes the liquid sample, forming sample droplets. A second sprayer provides multiple charged droplets of a liquid solvent or solution. The first sprayer forms a first angle (?) relative to the second sprayer such that the analytes are transferred to the charged droplets and are desolvated to generate free gas phase ions in an interface of a mass spectrometer (MS).