Patents by Inventor R. Hanson

R. Hanson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080268468
    Abstract: The present disclosure relates to a method for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates. The disclosed method incorporates alkynyl derivatized Fuc and alkynyl derivatized ManNAc sugars into a cellular glycoconjugate. A chemical probe comprising an azide group and a visual probe or a fluorogenic probe is used to label the alkyne-derivatized sugar-tagged glycoconjugate. In one aspect, the chemical probe binds covalently to the alkynyl group by Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition and is visualized at the cell surface, intracellularly, or in a cellular extract. The labeled glycoconjugate is capable of detection by flow cytometry, SDS-PAGE, Western blot, ELISA or confocal microscopy, and mass spectrometry.
    Type: Application
    Filed: March 24, 2008
    Publication date: October 30, 2008
    Inventors: CHI-HUEY WONG, TSUI-LING HSU, SARAH R. HANSON
  • Publication number: 20080241903
    Abstract: Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars.
    Type: Application
    Filed: April 8, 2008
    Publication date: October 2, 2008
    Applicant: The Scripps Research Institute
    Inventors: Peter G. Schultz, Sarah R. Hanson, Ran Xu, Zhiwen Zhang, Chi-Huey Wong
  • Publication number: 20080241856
    Abstract: The disclosure provides a method of labeling of cellular glycans bearing azide groups via a fluorescent labeling technique based on Cu(I)-catalyzed [3+2]cycloaddition (click activation) of a probe comprising an alkynyl group. The method entails generating a fluorescent probe from a nonfluorescent precursor, 4-ethynyl-N-ethyl-1,8-naphthalimide, by Cu(I)-catalyzed [3+2]cycloaddition of the alkyne group of the probe with an azido-modified sugar. The disclosure further provides a method of incorporating an azido-containing fucose analog into glycoconjugates via the fucose salvage pathway. The disclosure provides a method of fluorescent visualization of fucosylated cells by flow cytometry when cells treated with 6-azidofucose are labeled with the click-activated fluorogenic probe or biotinylated alkyne. A method of visualizing the intracellular localization of fucosylated glycoconjugates by fluorescence microscopy is also disclosed.
    Type: Application
    Filed: March 24, 2008
    Publication date: October 2, 2008
    Inventors: Chi-Huey Wong, Tsui-Ling Hsu, Sarah R. Hanson, Masaaki Sawa
  • Publication number: 20080238813
    Abstract: A display system for a handheld computing device includes a processing unit having a first communication port, and a visual display unit separable from the processing unit. The visual display unit further includes a visual display, and a second communication port. The display unit can be expanded from an initial or storage state to present a larger visual display size. Further, the first communication port providing communication with the second communication port.
    Type: Application
    Filed: April 7, 2008
    Publication date: October 2, 2008
    Inventors: Shawn R. Gettemy, Sherridythe A Fraser, Kevin Lee, William R. Hanson, Yoon Kean Wong, Mark W. Oliver
  • Patent number: 7423763
    Abstract: Systems and methods are described for faster processing of multiple spatially-heterodyned direct to digital holograms.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: September 9, 2008
    Assignee: UT-Battelle LLC
    Inventors: Gregory R. Hanson, Philip R. Bingham
  • Patent number: 7397261
    Abstract: A universal leakage monitoring system (ULMS) to measure a plurality of leakage macros during the development of a manufacturing process or a normal operation period. The ULMS characterizes the leakage of both n-type and p-type CMOS devices on the gate dielectric leakage, the sub-threshold leakage, and the reverse biased junction leakage, and the like. Testing is performed sequentially from the first test macro up to the last test macro using an on-chip algorithm. When the last test macro is tested, it scans the leakage data out.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: July 8, 2008
    Assignee: International Business Machines Corporation
    Inventors: Louis Lu-Chen Hsu, Edward R. Pillai, Joseph Natonio, James D. Rockrohr, David R. Hanson
  • Patent number: 7378263
    Abstract: Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: May 27, 2008
    Assignee: The Scripps Research Institute
    Inventors: Peter G. Schultz, Sarah R. Hanson, Ran Xu, Zhiwen Zhang, Chi-Heuy Wong
  • Patent number: 7348964
    Abstract: A single-piece top surface display and integrated front cover for an electronic device. In one embodiment, the cover comprises a thin, flexible, transparent layer coupled with a supporting structure. The flexible layer is supported above a display screen which is coupled with pressure activated sensors located under the display screen. The cover is dust-free, waterproof, and has a flat outer surface that is free of any steps or indentations. Users input data by applying pressure on the cover which causes the display screen to deflect and activate the sensors. The pressure exerted on the sensors is triangulated to register the position of the user input. In another embodiment, the cover is transparent, rigid, and directly contacts the pressure activated sensors which are located in front of the display screen or in the housing behind it. When pressure is applied to the cover, the cover deflects and activates the sensors. In both embodiments, an accelerometer identifies valid input events.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: March 25, 2008
    Assignee: Palm, Inc.
    Inventors: Shawn R. Gettemy, William R. Hanson, Lawrence Lam, Anna P. Slothower
  • Patent number: 7349100
    Abstract: Systems and methods are described for recording multiple spatially-heterodyned direct to digital holograms in one digital image.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: March 25, 2008
    Assignee: UT-Battelle LLC
    Inventors: Gregory R. Hanson, Philip R. Bingham
  • Publication number: 20080016886
    Abstract: A freezer for the storage of blood plasma and other blood products is disclosed.
    Type: Application
    Filed: July 20, 2006
    Publication date: January 24, 2008
    Applicant: HELMER, INC.
    Inventors: Jeremy Slate, James R. Hanson
  • Patent number: 7312875
    Abstract: Systems and methods are described for obtaining two-wavelength differential-phase holograms. A method includes determining a difference between a filtered analyzed recorded first spatially heterodyne hologram phase and a filtered analyzed recorded second spatially-heterodyned hologram phase.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: December 25, 2007
    Assignee: UT-Battelle LLC
    Inventors: Gregory R. Hanson, Philip R. Bingham, John T. Simpson, Thomas P. Karnowski, Edgar Voelkl
  • Patent number: 7298532
    Abstract: A method of writing a spatially heterodyne hologram having spatially heterodyne fringes includes: passing a single write beam through a spatial light modulator that digitally modulates said single write beam; and focusing the single write beam at a focal plane of a lens to impose a holographic diffraction grating pattern on the photorefractive crystal, the holographic diffraction grating pattern including the spatially heterodyne hologram having spatially heterodyne fringes, wherein only said single write beam is incident on said photorefractive crystal without a reference beam.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: November 20, 2007
    Assignee: UT-Battelle LLC
    Inventors: Clarence E. Thomas, Gregory R. Hanson
  • Patent number: 7242239
    Abstract: A circuit is provided which is operable to program an electrically alterable element, e.g., fuse or antifuse, to a programmed state and determine whether the electrically alterable element is in the programmed state or not. Such circuit includes a multiple conduction state field effect transistor (“multi-state FET”) having at least one of a source or a drain coupled to the electrically alterable element to apply a current to the electrically alterable element. The multi-state FET has a first threshold voltage and a second threshold voltage, both being effective at the same time, the second threshold voltage being higher than the first threshold voltage.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: July 10, 2007
    Assignee: International Business Machines Corporation
    Inventors: David R. Hanson, Dureseti Chidambarrao, Gregory J. Fredeman, David M. Onsongo
  • Patent number: 7223583
    Abstract: The present invention relates to novel antithrombotic variants of thrombin or fragments thereof that are capable of proteolytically activating protein C, but which are substantially free of fibrinogen cleavage activity. The present invention further relates to variant polypeptides that may be cleaved to yield active thrombin variants. The present invention also relates to methods of inhibiting thrombus formation in an animal or human subject by delivering an antithrombotic variant thrombin of the present invention to the blood of the subject. The present invention relates also to methods that use the novel variant thrombins for determining the level of protein C activation in a blood sample, or the thrombogenic potential of a patient.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: May 29, 2007
    Assignee: Emory University
    Inventors: Andras Gruber, Stephen R. Hanson, Enrico De Cera
  • Patent number: 7165962
    Abstract: A telescoping roll stand for use in an extrusion line includes a linkage connecting one or more auxiliary rolls in a spatial relationship relative to each other and other auxiliary web processing components, including conveyors, load cell rolls, draw rolls, and other web handling components, when one of the auxiliary rolls is shifted in relation to a primary roll.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: January 23, 2007
    Inventor: Dana R. Hanson
  • Patent number: 7148969
    Abstract: An apparatus operable to record a spatially low-frequency heterodyne hologram including spatially heterodyne fringes for Fourier analysis includes: a laser; a beamsplitter optically coupled to the laser; an object optically coupled to the beamsplitter; a focusing lens optically coupled to both the beamsplitter and the object; a digital recorder optically coupled to the focusing lens; and a computer that performs a Fourier transform, applies a digital filter, and performs an inverse Fourier transform.
    Type: Grant
    Filed: January 9, 2006
    Date of Patent: December 12, 2006
    Assignee: UT-Battelle LLC
    Inventors: Clarence E. Thomas, Gregory R. Hanson
  • Patent number: 7137039
    Abstract: A device driver (GRAPHICS, NETWORK, H2IO, IO2L, SERIAL) for use in a computer system comprising a processor (P), memory (M) and a device (GRAPHICS, NETWORK, H2IO, IO2L, SERIAL) operatively coupled to the computer system, the device driver being operable to control the device to monitor an operational status of the device, and consequent upon a change in the operational status to generate a fault report data indicating whether the change of status was caused internally within the device or externally by another connected device which caused the change of operational status to occur. The fault reports may also include an indication of the operational status of the device. Furthermore, if the fault report data indicates that the change of status was caused externally, the device driver may generate fault direction information indicative of an apparent direction on a connection between the device and the other device suspected as causing the indicated external fault.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: November 14, 2006
    Assignee: Sun Microsystems, Inc.
    Inventors: Paul Durrant, Stephen R Hanson, David S Gordon, Jeremy Harris
  • Patent number: 7136317
    Abstract: A random access memory (RAM), such as a dynamic RAM (DRAM) or embedded DRAM (eDRAM) on a CMOS integrated circuit (IC) logic chip. Memory banks drive one line of a connected global data line pair to develop a difference signal on the pair. Simultaneously, a global signal monitor line discharges to develop a signal that mirrors the signal developing on one of the pair. When the global signal monitor line discharges sufficiently to indicate that the difference signal is large enough to sense, a global sense control sets a global data sense amplifier, the memory banks drive shuts off, and the global sense control initiates restoring global data line.
    Type: Grant
    Filed: August 10, 2005
    Date of Patent: November 14, 2006
    Assignee: International Business Machines Corporation
    Inventors: David R. Hanson, Hoki Kim
  • Patent number: 7123529
    Abstract: An integrated circuit is provided which includes a sensing circuit. In the sensing circuit, a pair of conductors including a first conductor and a second conductor are adapted to conduct a first differential signal having a small voltage difference and a second differential signal having a rail-to-rail voltage difference. A sense amplifier is coupled to the pair of conductors, the sense amplifier being operable to amplify the first differential signal into the second differential signal. The sensing circuit further includes a multiple conduction state field effect transistor or “multi-state FET” which has a source, a drain, and a gate operable to control conduction between the source and the drain.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: October 17, 2006
    Assignee: International Business Machines Corporation
    Inventors: David R. Hanson, David M. Onsongo, Dureseti Chidambarrao
  • Patent number: 7119905
    Abstract: Systems and methods are described for spatial-heterodyne interferometry for transmission (SHIFT) measurements. A method includes digitally recording a spatially-heterodyned hologram including spatial heterodyne fringes for Fourier analysis using a reference beam, and an object beam that is transmitted through an object that is at least partially translucent; Fourier analyzing the digitally recorded spatially-heterodyned hologram, by shifting an original origin of the digitally recorded spatially-heterodyned hologram to sit on top of a spatial-heterodyne carrier frequency defined by an angle between the reference beam and the object beam, to define an analyzed image; digitally filtering the analyzed image to cut off signals around the original origin to define a result; and performing an inverse Fourier transform on the result.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: October 10, 2006
    Assignee: UT-Battelle LLC
    Inventors: Philip R. Bingham, Gregory R. Hanson, Ken W. Tobin