Abstract: The present invention provides compositions and methods for noninvasive delivery of therapeutic agents across an intact tympanic membrane. For example, the compositions include a penetration enhancer which increases the flux of a therapeutic agent (e.g., antibiotic) across the tympanic membrane. Such compositions are particularly useful in the treatment of otitis media. Additionally, the composition may include a sustained release agents that, in some embodiments form sustained release reservoirs, in situ, once administered to a patient.

Abstract: The present invention relates generally to devices and methods for administering one or more active agents to the eye of a human or animal patient in need thereof, and more particularly to devices for application to the cornea which release active agent to the eye in a controlled manner.

Abstract: A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an “always on” active RF receiving element to anticipate a wake-up signal for the balance of the transponder electronics. This solution allows the entire active transponder to have all circuit elements in a sleep (standby) state, thus drastically extending battery life or other charge storage device life. Also, a wake-up solution that reduces total energy consumption of an active transponder system by allowing all non-addressed transponders to remain in a sleep (standby) state, thereby reducing total system or collection energy. Also, the transponder and wake-up solution are employed in an asset tracking system.

Abstract: A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an “always on” active RF receiving element to anticipate a wake-up signal for the balance of the transponder electronics. This solution allows the entire active transponder to have all circuit elements in a sleep (standby) state, thus drastically extending battery life or other charge storage device life. Also, a wake-up solution that reduces total energy consumption of an active transponder system by allowing all non-addressed transponders to remain in a sleep (standby) state, thereby reducing total system or collection energy. Also, the transponder and wake-up solution are employed in an asset tracking system.

Abstract: A method of designing an integrated circuit for use in an application having standards having a plurality of primitives, wherein each of the primitives has a corresponding response. The method includes generating a macros description of each of the primitives and the response corresponding to each of the primitives, generating a template relating to the response corresponding to each of the primitives, receiving information specifying a behavior of the integrated circuit in response to the primitives based on the template, and generating a hardware description language representation for the integrated circuit based on the macros description and the information.

Abstract: The present invention generally relates to systems and methods for releasing a releasable species from an article using an external trigger, for example, using infrared or near-infrared radiation. Such systems and methods may be useful, for example in biological applications (e.g., as an implant within a subject), industrial applications, commercial applications, or the like. One aspect of the invention is generally directed to an article containing a radiation-sensitive polymer or other radiation-sensitive material. Exposure of the radiation-sensitive material to radiation such as infrared or near-infrared radiation may cause the material to increase in temperature. This increase in temperature may be used, in some cases, to cause the release of a drug or other releasable species from the article.

Abstract: A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an “always on” active RF receiving element to anticipate a wake-up signal for the balance of the transponder electronics. This solution allows the entire active transponder to have all circuit elements in a sleep (standby) state, thus drastically extending battery life or other charge storage device life. Also, a wake-up solution that reduces total energy consumption of an active transponder system by allowing all non-addressed transponders to remain in a sleep (standby) state, thereby reducing total system or collection energy. Also, the transponder and wake-up solution are employed in an asset tracking system.

Abstract: The present invention generally relates to systems and methods for releasing a releasable species from an article using an external trigger, for example, using microwave radiation or other forms of radiation, e.g., radiofrequency radiation. Such systems and methods may be useful, for example, in biological applications (e.g., as an implant within a subject), industrial applications, commercial applications, or the like. One aspect of the invention is generally directed to an article containing a radiation-sensitive polymer or other radiation-sensitive material. Exposure of the radiation- sensitive material to radiation such as microwave and/or radiofrequency radiation may cause the material to increase in temperature. This increase in temperature may be used, in some cases, to cause the release of a drug or other releasable species from the article.

Abstract: The present invention generally relates to systems and methods for releasing a compound from an article using an external trigger, for example, magnetic fields. One aspect of the invention is generally directed to an article containing a magnetically-susceptible material. Exposure of the magnetically-susceptible material to a magnetic field, such as an oscillating magnetic field, may cause the magnetically-susceptible material to increase in temperature. This increase in temperature may be used, in some embodiments, to cause the release of a drug or other releasable material from the article. For instance, the drug may be contained in a heat-sensitive material in thermal communication with the magnetically-susceptible material, or the drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material in thermal communication with the magnetically-susceptible material. Other aspects of the invention are directed to systems and methods of making or using such articles, e.

Abstract: An oil and gas well shaped charge perforator is provided comprising a housing, a high explosive, and a liner with a further insert liner where the high explosive is positioned between the liner and the housing. In use the high explosive will collapse the liner and insert causing two cutting jets to form. The insert may substantially cover the surface area of the liner or it may over only partially cover the liner, such as the apical portion of the liner or the base portion of liner. Alternatively the insert may be varied in thickness across the surface area of the liner. Typically the thickness of the liner may be between 1 and 10% of the liner diameter and the thickness of the insert may be between 1 and 200% of the thickness of the liner. The insert may be produced during the manufacture of the liner, but preferably the liner will be a retro fitted item.

Abstract: The present invention provides compositions and methods for noninvasive delivery of therapeutic agents across an intact tympanic membrane. For example, the compositions include a penetration enhancer which increases the flux of a therapeutic agent (e.g., antibiotic) across the tympanic membrane. Such compositions are particularly useful in the treatment of otitis media. Additionally, the composition may include a sustained release agents that, in some embodiments form sustained release reservoirs, in situ, once administered to a patient.

Abstract: A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an “always on” active RF receiving element to anticipate a wake-up signal for the balance of the transponder electronics. This solution allows the entire active transponder to have all circuit elements in a sleep (standby) state, thus drastically extending battery life or other charge storage device life. Also, a wake-up solution that reduces total energy consumption of an active transponder system by allowing all non-addressed transponders to remain in a sleep (standby) state, thereby reducing total system or collection energy. Also, the transponder and wake-up solution are employed in an asset tracking system.

Abstract: A method for completing an oil and gas well completion is provided. The perforators (10, 11) may be selected from any known or commonly used perforators and are typically deployed in a perforation gun. The perforators are aligned such that the cutting jets (12, 13) and their associated shockwaves converge towards each other such that their interaction causes increased fracturing of the rock strata. The cutting jets may be also be aligned such that the cutting jets are deliberately caused to collide causing further fracturing of the rock strata. In Ian alternative embodiment of the invention there is provided a shaped charge liner with at least two concave regions, whose geometry is selected such that upon the forced collapse of the liner a plurality of cutting jets is formed which jets are convergent or are capable of colliding in the rock strata.

Abstract: A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an “always on” active RF receiving element to anticipate a wake-up signal for the balance of the transponder electronics. This solution allows the entire active transponder to have all circuit elements in a sleep (standby) state, thus drastically extending battery life or other charge storage device life. Also, a wake-up solution that reduces total energy consumption of an active transponder system by allowing all non-addressed transponders to remain in a sleep (standby) state, thereby reducing total system or collection energy. Also, the transponder and wake-up solution are employed in an asset tracking system.

Abstract: The present invention relates generally to devices and methods for administering one or more active agents to the eye of a human or animal patient in need thereof, and more particularly to devices for application to the cornea which release active agent to the eye in a controlled manner.

Abstract: A power management method for a transponder having a plurality of circuits including at least a first circuit having a first active state requiring at least a first power level, and a second circuit having a second active state requiring at least a second power level greater than the first power level includes receiving a reader device signal in the first circuit, determining in the first circuit, based on information included in the reader signal, whether the reader signal requires a circuit other than the first circuit to operate, and causing the first circuit to provide a wake-up signal and the reader signal to the second circuit if it is determined that the reader signal requires a circuit other than the first circuit to operate. The wake-up signal causes the second circuit to move from an inactive state to the second active state.

Abstract: In a JTAG test and debug environment, the signal groups for boundary scans can have several lengths including signal groups that are longer that the shift register out. A storage unit is provided with a plurality of storage location lengths. The boundary scan signal groups are stored in a location having a suitable storage capacity. The command that transfers the boundary scan signal group includes a parameter identifying the relevant location. The scan control unit, upon receiving the command, transfers the entire boundary scan signal group as a result this command even if several transfers through the shift register out are required.

Abstract: A method of designing an integrated circuit for use in an application having standards having a plurality of primitives, wherein each of the primitives has a corresponding response. The method includes generating a macros description of each of the primitives and the response corresponding to each of the primitives, generating a template relating to the response corresponding to each of the primitives, receiving information specifying a behavior of the integrated circuit in response to the primitives based on the template, and generating a hardware description language representation for the integrated circuit based on the macros description and the information.

Abstract: An oil and gas well shaped charge perforator is provided comprising a housing, a high explosive, and a liner with a further insert liner where the high explosive is positioned between the liner and the housing. In use the high explosive will collapse the liner and insert causing two cutting jets to form. The insert may substantially cover the surface area of the liner or it may over only partially cover the liner, such as the apical portion of the liner or the base portion of liner. Alternatively the insert may be varied in thickness across the surface area of the liner. Typically the thickness of the liner may be between 1 and 10% of the liner diameter and the thickness of the insert may be between 1 and 200% of the thickness of the liner. The insert may be produced during the manufacture of the liner, but preferably the liner will be a retro fitted item.

Abstract: A method of generating software code for a processor of an IC based on a simple input description of the IC's standards. The method includes generating a macros description of each of the primitives from the standards and the response corresponding to each of the primitives, wherein the macros description includes information relating to a number of first fields for each of the primitives and a number of second fields for each response. The method further includes generating a blank version of a template that includes each of the second fields and receiving a completed version of the template, wherein the completed template specifies a behavior of the integrated circuit in response to the primitives. Finally, the method includes compiling the software code based on the macros description and the completed version of the template. Also, a software tool implementing the method is provided.