Abstract: An automated small particle distribution system is provided for transferring small particles from source tubes to destination tubes. The system includes a loading deck that is structured and operable to store and provide a plurality of source tube trays and a plurality of destination tube trays. Each source tube tray includes a plurality of source tubes stored therein, and each destination tube tray includes a plurality of destination tubes stored therein. The system additionally includes a work deck is structured and operable to receive selected source tube trays and selected destination tube trays from the loading deck, aspirate various specified amounts of small objects stored in selected source tubes, and deposit the aspirated small objects into selected destination tubes without cross-contamination of small objects.

Abstract: A computer based simulation system for virtual training for vehicle crews is disclosed. The Vehicle Crew Training System (VCTS) simulates crew positions for different military ground and air vehicles. Two or more crewman modules are networked together to support a partial or full vehicle crew. The crewman modules are self-contained devices that are modular in hardware and software design, easily reconfigurable, and require minimal facility space, allowing use in restricted environments such as trailers. The VCTS is modular at the crew position level; crewman modules are added or deleted as required to meet a particular training need.

Abstract: A computer based simulation system for virtual training for vehicle crews is disclosed. The Vehicle Crew Training System (VCTS) simulates crew positions for different military ground and air vehicles. Two or more crewman modules are networked together to support a partial or full vehicle crew. The crewman modules are self-contained devices that are modular in hardware and software design, easily reconfigurable, and require minimal facility space, allowing use in restricted environments such as trailers. The VCTS is modular at the crew position level; crewman modules are added or deleted as required to meet a particular training need.

Abstract: A computer based simulation system for virtual training for vehicle crews is disclosed. The vehicle crew training system (VCTS) simulates crew positions for different military vehicles. Two or more crewman modules are networked together to support a partial or full vehicle crew. The crewman modules are self-contained devices that are modular in hardware and software design, easily reconfigurable, and that require minimal facility space, allowing use in restricted environments such as trailers. The VCTS is modular at the crew position level; crewman modules are added or deleted as required to meet a particular training need. One of the crewman modules can be a gunner module, which provides an unrestricted view of the simulated environment to the gunner by means of a display and a simulated vehicle-mounted weapon.

Abstract: A method of particle mitigation which includes obtaining a semiconductor wafer having a nonfunctional backside and a functional frontside on which semiconductor devices are formed by one or more lithography processes; coating the backside with a layer comprising silicon or amorphous carbon; planarizing the coated backside by a planarizing process; placing the semiconductor wafer onto a wafer chuck such that the wafer chuck makes direct contact with the coated backside; and while maintaining the coated backside in direct contact with the wafer chuck, performing a first lithographic process on the frontside.

Abstract: A computer based simulation system for virtual training for vehicle crews is disclosed. The Vehicle Crew Training System (VCTS) simulates crew positions for different military ground and air vehicles. Two or more crewman modules are networked together to support a partial or full vehicle crew. The crewman modules are self-contained devices that are modular in hardware and software design, easily reconfigurable, and require minimal facility space, allowing use in restricted environments such as trailers. The VCTS is modular at the crew position level; crewman modules are added or deleted as required to meet a particular training need.

Abstract: A method of particle mitigation which includes obtaining a semiconductor wafer having a nonfunctional backside and a functional frontside on which semiconductor devices are formed by one or more lithography processes; coating the backside with a layer comprising silicon or amorphous carbon; planarizing the coated backside by a planarizing process; placing the semiconductor wafer onto a wafer chuck such that the wafer chuck makes direct contact with the coated backside; and while maintaining the coated backside in direct contact with the wafer chuck, performing a first lithographic process on the frontside.

Abstract: A method of particle mitigation which includes obtaining a semiconductor wafer having a nonfunctional backside and a functional frontside on which semiconductor devices are formed by one or more lithography processes; coating the backside with a mitigating layer comprising silicon or amorphous carbon; patterning the mitigating layer to form indentations in the mitigating layer; placing the semiconductor wafer onto a wafer chuck such that the wafer chuck makes direct contact with the coated and patterned backside mitigating layer; and while maintaining the coated and patterned backside mitigating layer in direct contact with the wafer chuck, performing a first lithographic process on the frontside.

Abstract: An automated small particle distribution system is provided for transferring small particles from source tubes to destination tubes. The system includes a loading deck that is structured and operable to store and provide a plurality of source tube trays and a plurality of destination tube trays. Each source tube tray includes a plurality of source tubes stored therein, and each destination tube tray includes a plurality of destination tubes stored therein. The system additionally includes a work deck is structured and operable to receive selected source tube trays and selected destination tube trays from the loading deck, aspirate various specified amounts of small objects stored in selected source tubes, and deposit the aspirated small objects into selected destination tubes without cross-contamination of small objects.

Abstract: A computer based simulation system for virtual training for vehicle crews is disclosed. The vehicle crew training system (VCTS) simulates crew positions for different military vehicles. Two or more crewman modules are networked together to support a partial or full vehicle crew. The crewman modules are self-contained devices that are modular in hardware and software design, easily reconfigurable, and that require minimal facility space, allowing use in restricted environments such as trailers. The VCTS is modular at the crew position level; crewman modules are added or deleted as required to meet a particular training need. One of the crewman modules can be a gunner module, which provides an unrestricted view of the simulated environment to the gunner by means of a display and a simulated vehicle-mounted weapon.

Abstract: A computer based simulation system for virtual training for vehicle crews is disclosed. The Vehicle Crew Training System (VCTS) simulates crew positions for different military ground and air vehicles. Two or more crewman modules are networked together to support a partial or full vehicle crew. The crewman modules are self-contained devices that are modular in hardware and software design, easily reconfigurable, and require minimal facility space, allowing use in restricted environments such as trailers. The VCTS is modular at the crew position level; crewman modules are added or deleted as required to meet a particular training need.

Abstract: A method for wafer bonding includes measuring grid distortion for a mated pairing of wafers to be bonded to determine if misalignment exists between the wafers. During processing of subsequent wafers, magnification of one or more lithographic patterns is adjusted to account for the misalignment. The subsequent wafers are bonded with reduced misalignment.

Abstract: A method for wafer bonding includes measuring grid distortion for a mated pairing of wafers to be bonded to determine if misalignment exists between the wafers. During processing of subsequent wafers, magnification of one or more lithographic patterns is adjusted to account for the misalignment. The subsequent wafers are bonded with reduced misalignment.

Abstract: A system and method are provided for tracking race participants via a Global Positioning System, providing feedback in substantially real time to the race participant, and optionally to other remote individuals via web publication at the user's preference. The feedback includes graphical and tabular presentation of such information as geographic position, race route, current race performance metrics, projection of future milestone and final race performance, projected position at a given time, projected time to a given position, relative performance to historical participants, to personal historical performance and to other members of the current race that are being tracked in aggregate or by demographic or otherwise subdivided.

Abstract: A computer based simulation system for virtual training for vehicle crews is disclosed. The vehicle crew training system (VCTS) simulates crew positions for different military vehicles. Two or more crewman modules are networked together to support a partial or full vehicle crew. The crewman modules are self-contained devices that are modular in hardware and software design, easily reconfigurable, and that require minimal facility space, allowing use in restricted environments such as trailers. The VCTS is modular at the crew position level; crewman modules are added or deleted as required to meet a particular training need. One of the crewman modules can be a gunner module, which provides an unrestricted view of the simulated environment to the gunner by means of a display and a simulated vehicle-mounted weapon.

Abstract: The present invention provides methods for designing agents such as ligands capable of binding to a Janus kinase (Jak), particularly a Jak2 JH2, and especially a JH2 V617F, screening methods for identifying agents such as ligands and small molecules capable of binding to the same, and computer assisted methods for designing and identifying such agents. Further, the present invention provides methods for treating myeloproliferative neoplasias (MPNs) along with agents such as ligands and small molecules identified or designed using the methods described.

Abstract: Systems and methods for application of fMRI as a biomarker of neural abnormalities are presented. A subject's activations of brain regions that occur while performing cognitive tasks in an fMRI scanning apparatus are measured. The resulting measurements are compared to the activations of brain regions that occur during each cognitive task for a control group. The comparison to the performance and brain activations of normal subjects determine the presence of cortical compensatory mechanisms that indicate neural abnormalities in the subject.

Abstract: A computer based simulation system for virtual training for vehicle crews is disclosed. The Vehicle Crew Training System (VCTS) simulates crew positions for different military ground and air vehicles. Two or more crewman modules are networked together to support a partial or full vehicle crew. The crewman modules are self-contained devices that are modular in hardware and software design, easily reconfigurable, and require minimal facility space, allowing use in restricted environments such as trailers. The VCTS is modular at the crew position level; crewman modules are added or deleted as required to meet a particular training need.

Abstract: Neurodegenerative diseases, such as multiple sclerosis, may be caused or aggravated by insufficient venous draining from the central nervous system. Functional MRI measures the surge of blood flow into localized regions of cerebral cortex in response to activation of those regions by performing visual, auditory or executive tasks. These fMRI measurements are based on blood-oxygen-level dependence. The resulting fMRI/BOLD data is converted to hemodynamic response data and analyzed to determine any abnormality in the hemodynamic response data. Vascular drainage insufficiency is identified in the presence of abnormal hemodynamic response data. Abnormal hemodynamic response data can be determined by a negative trough in a graph of the HDR data or by the duration, depth, or area of the negative trough.

Abstract: Neurodegenerative diseases, such as multiple sclerosis, may be caused or aggravated by insufficient venous draining from the central nervous system. Functional MRI measures the surge of blood flow into localized regions of cerebral cortex in response to activation of those regions by performing visual, auditory or executive tasks. These fMRI measurements are based on blood-oxygen-level dependence. The resulting fMRI/BOLD data is converted to hemodynamic response data and analyzed to determine any abnormality in the hemodynamic response data. Vascular drainage insufficiency is identified in the presence of abnormal hemodynamic response data. Abnormal hemodynamic response data can be determined by a negative trough in a graph of the HDR data or by the duration, depth, or area of the negative trough.