Abstract: Described herein is a recombinant TMEM2 extracellular domain which can be used as an adjuvant to increase the injection volume and dispersion of compositions containing one or more therapeutic agents. Methods of preparing recombinant TMEM2 extracellular domain protein and their use in combination with one or more therapeutic agents as medicaments are provided.

Abstract: This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.

Abstract: A gas turbine engine with a lubrication system includes a ball bearing assembly and a rotor circumscribing a rotational axis and journaled within the ball bearing assembly. The gas turbine engine also includes a lubrication system located radially outward from a rotational axis and radially outward and adjacent to the ball bearing assembly, which includes a lubrication channel having an inlet and an outlet and a dispersion cone adjacent to the outlet of the lubrication channel.

Abstract: An accessory support platform is provided for supporting a removable accessory, e.g. a stair system or cabinet, adjacent to a vehicle or portable living quarter, such as a truck-bed mounted camper. The accessory platform includes a support frame for coupling the platform to the truck camper. The support frame supports or suspends a support rail system from the rear portion of the truck camper. The rail system includes an upper support rail and a lower support rail that is suspended below and apart from the upper rail. The removable accessory may be coupled at one of or between both of the upper and lower support rails. The removable accessory is preferably readily repositionable relative to the upper and lower support rails. A coupling bracket and/or hanger secures the removable accessory to the rail system.

Abstract: A monolithic combustion liner for use in a gas turbine engine includes fuel channels integrated into the wall of the combustion liner. The integrated fuel channels can have an aerodynamic shape to reduce flow losses of cooling air flowing around the exterior of the combustion liner. The monolithic combustion liner allows more cooling air to flow around the combustion liner, increasing the cooling of the combustor region of the gas-turbine engine.

Abstract: During a formation method, a build plate is arranged within a build space. A first object is built onto the build plate within the build space using an additive manufacturing process. The object is fused to the build plate during the additive manufacturing process. At least the build plate is machined to form a component that includes a portion of the build plate and at least a portion of the first object.

Abstract: A system and method for performing staggered separations are described. The system includes a plurality of solvent pumps; a plurality of proportioning valves each being in fluid communication with one of the solvent pumps, each proportioning valve having an inlet to receive a solvent from the respective one of the solvent pumps and having a plurality of outlets, wherein the proportioning valves are configured to control a flow of the solvent from each of the outlets; and a plurality of separation devices each in fluid communication with one of the outlets. Each of the separation devices receives a solvent mixture having a composition defined by the flows of the solvents from each of the respective outlets.

Abstract: Various embodiments include an actuated projectile launcher, including: a base structure; a projectile support, and a holding area from which a projectile launches; propulsion wheels selectively driven to rotate; and support arms, each supporting at a first end thereof a separate one of the propulsion wheels and being supported at an opposed second end thereof by the base structure. The support arms are configured to move the propulsion wheels between an expanded position and a contracted position, in which the propulsion wheels are closer to one another in the contracted position as compared to the expanded position. The movement of the propulsion wheels toward the contracted position brings the propulsion wheels into engagement with the projectile and drives the projectile from the holding area.

Abstract: Generally, a radio control system can provide the primary transmit controller or provide a secondary transmit controller to an existing radio transmit controller to control a radio control device. Specifically, a mobile application operable by a mobile device to provide a primary transmit controller, or provide a secondary transmit controller to an existing radio transmit controller, which receives and associates one or more channels of primary control instructions of a radio control device with one or more user interface elements of a radio control interface displayed on the mobile device which by user interaction generates secondary control instructions corresponding one or more channels of the primary control instructions to generate control signal data corresponding to the secondary control instructions to wirelessly control the radio control device.

Abstract: This provides a system and method for analyzing and diagnosing conditions, such as cancer, based upon stained tissue sample slides prepared by users from patient tissue taken, for example, in a biopsy procedure. A convolutional neural network (CNN) is generated at training time. Slide images are acquired/scanned, and individual cell nuclei from the images are annotated, using IHC. H&E images are acquired/scanned prior to a washout intermediate step from the same slides/tissue samples. IHC is performed on the same tissue layer, which was scanned and used to retrospectively annotate the H&E WSI. IHC is used to annotate a ground truth mask for machine learning. The resultant process achieves a high degree of spatial resolution in detecting individual IHC positive nuclei, yielding process that is almost entirely automated, employing materials that are commonly available in clinical practice. In runtime, users access the CNN to perform analysis on patient slides.

Abstract: The present disclosure relates to an article (1) for use in an aerosol provision system (200). The article (1) comprises an aerosol generating material (3), a receiving member (2) and a blocking member (4). The receiving member (2) comprises an end wall (8), an open end (7), and a peripheral wall (5) that surrounds a storage area (6) containing the aerosol-generating material (3). The blocking member (4) comprises a body of material (12) arranged to resist the aerosol-generating material (3) from moving out of the storage area (6) through the open end (7) of the receiving member (2). The present disclosure also relates to a method (100) of manufacturing an article (1) for use in an aerosol provision system (200). The present disclosure also relates to an aerosol provision system (200) comprising an article (1) and to a package of articles.

Abstract: A deployable hay pod elevator system for a transport vehicle, such as a livestock trailer, provides a readily deployable hay pod, storage pod, or supply platform with the trailer, and is readily stowable above the trailer in a raised configuration for travel. The elevator system includes a deployable supply platform and a lift system configured to raise and lower the supply platform relative to the trailer. The lift system may include a screw drive system or a winch and cable system to vertically raise and lower the deployable supply platform. The lift system may pivot or rotate the hay pod over the top of the trailer for transportation purposes. The deployable hay pod elevator system can be fitted to a truck, a van, or other types of vehicles and can be configured to store and transport various materials, such as hay, tools, or livestock tack.

Abstract: An assembly is provided for an aerial vehicle. This assembly includes an airframe and a fluid circuit. The airframe includes a body and an airfoil projecting out from the body. The airfoil includes a first surface and a first aperture in the first surface. The fluid circuit is configured to bleed gas from a gas turbine engine mounted to the airframe to provide control gas. The fluid circuit is configured to selectively direct the control gas to the first aperture.

Abstract: An assembly is provided for a gas turbine engine. This assembly includes a compressor rotor, a turbine rotor and a cooling circuit. The compressor rotor includes a gas path surface. The turbine rotor is rotatable with the compressor rotor about a rotational axis. The cooling circuit includes an inlet in the gas path surface. The cooling circuit extends from the inlet, through the compressor rotor and into the turbine rotor.

Abstract: An engine system is provided that includes a gas turbine engine and an actuation system. The gas turbine engine includes a compressor section, a combustor section, a turbine section and a flowpath extending through the compressor section, the combustor section and the turbine section. The actuation system includes a fluid reservoir, a flow regulator and a flow circuit. The flow regulator is configured as or otherwise includes a barrier between the fluid reservoir and the flow circuit. The flow regulator is configured to fluidly decouple the fluid reservoir from the flow circuit when the barrier is intact. The flow regulator is configured to fluidly couple the fluid reservoir with the flow circuit when the barrier breaks. The flow circuit is configured to direct gas from the fluid reservoir into the flowpath when the barrier breaks.

Abstract: An accessory support platform is provided for supporting a removable accessory, e.g. a stair system or cabinet, adjacent to a vehicle or portable living quarter, such as a truck-bed mounted camper. The accessory platform includes a support frame for coupling the platform to the truck camper. The support frame supports or suspends a support rail system from the rear portion of the truck camper. The rail system includes an upper support rail and a lower support rail that is suspended below and apart from the upper rail. The removable accessory may be coupled at one of or between both of the upper and lower support rails. The removable accessory is preferably readily repositionable relative to the upper and lower support rails. A coupling bracket and/or hanger secures the removable accessory to the rail system.

Abstract: Various implementations include portable speakers and methods configured to adjust audio input signals. In one example, a portable speaker includes: at least one electro-acoustic transducer for providing an acoustic output; an audio input for receiving one or more audio input signals; an audio output for providing one or more audio output signals; a communication module for providing a network communication link; and a processor configured to receive the audio input signals and to process the audio input signals to provide the audio output signals, wherein the processor is configured, from a common set of audio input signals, to provide, a first set of audio output signals to the electro-acoustic transducer, such that the first set of audio output signals act as a monitor of the one or more audio input signals, and a second set of audio output signals via the network communication link.

Abstract: A manufacturing method is provided during which a body is additively manufactured. The body includes an engine case for a gas turbine engine, a support structure and an aperture. The support structure projects out from the engine case. The support structure includes a lattice, a wall and an internal volume. The wall surrounds the lattice. The internal volume is within the support structure along the lattice. The internal volume is filled with powder. The aperture is at an intersection between the engine case and the support structure. The powder is extracted from the internal volume through the aperture.

Abstract: A system is provided for an aerial vehicle. This system includes a splash plate, a fuel nozzle and a gas circuit. The splash plate includes a splash plate surface. The fuel nozzle includes a nozzle orifice. The fuel nozzle is configured to direct fuel out of the nozzle orifice to impinge against the splash plate surface. The gas circuit includes a gas passage and a gas outlet. At least a portion of the gas passage is formed by and embedded within the splash plate. The gas passage extends through the splash plate to the gas outlet.

Abstract: A deployable hay pod elevator system for a transport vehicle, such as a livestock trailer, provides a readily deployable hay pod, storage pod, or supply platform with the trailer, and is readily stowable above the trailer in a raised configuration for travel. The elevator system includes a deployable supply platform and a lift system configured to raise and lower the supply platform relative to the trailer. The lift system may include a screw drive system or a winch and cable system to vertically raise and lower the deployable supply platform. The lift system may pivot or rotate the hay pod over the top of the trailer for transportation purposes. The deployable hay pod elevator system can be fitted to a truck, a van, or other types of vehicles and can be configured to store and transport various materials, such as hay, tools, or livestock tack.