Patents by Inventor R. Jeremy Johnson

R. Jeremy Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cytotoxic ribonuclease variants
    Patent number: 9234191
    Abstract: Cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex are disclosed. Also disclosed is the 3-D structure of the hRI.RNase 1 complex and methods for designing and using the RNase 1 variants.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: January 12, 2016
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, George N. Phillips, Jr., R. Jeremy Johnson, Jason G. McCoy
  • CYTOTOXIC RIBONUCLEASE VARIANTS
    Publication number: 20140038288
    Abstract: Cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex are disclosed. Also disclosed is the 3-D structure of the hRI.RNase 1 complex and methods for designing and using the RNase 1 variants.
    Type: Application
    Filed: October 4, 2013
    Publication date: February 6, 2014
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Ronald T. Raines, George N. Phillips, JR., R. Jeremy Johnson, Jason G. McCoy
  • Cytotoxic ribonuclease variants
    Patent number: 8569457
    Abstract: Cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex are disclosed. Also disclosed is the 3-D structure of the hRI·RNase 1 complex and methods for designing the RNase 1 variants.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: October 29, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, George N. Phillips, Jr., R. Jeremy Johnson, Jason G. McCoy
  • CYTOTOXIC RIBONUCLEASE VARIANTS
    Publication number: 20130011904
    Abstract: Cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex are disclosed. Also disclosed is the 3-D structure of the hRI·RNase 1 complex and methods for designing the RNase 1 variants.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, George N. Phillips, JR., R. Jeremy Johnson, Jason G. McCoy
  • Cytotoxic ribonuclease variants
    Patent number: 8293872
    Abstract: This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex. Also disclosed is the 3-D structure of the hRI•RNase 1 complex and methods for designing the RNase 1 variants.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: October 23, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, George N. Phillips, Jr., R. Jeremy Johnson, Jason G. McCoy
  • CYTOTOXIC RIBONUCLEASE VARIANTS
    Publication number: 20120009173
    Abstract: This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex. Also disclosed is the 3-D structure of the hRI•RNase 1 complex and methods for designing the RNase 1 variants.
    Type: Application
    Filed: September 23, 2011
    Publication date: January 12, 2012
    Inventors: Ronald T. Raines, George N. Philllips, JR., R. Jeremy Johnson, Jason G. McCoy
  • Cytotoxic ribonuclease variants
    Patent number: 8048425
    Abstract: This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex. Also disclosed is the 3-D structure of the hRI•RNase 1 complex and methods for designing the RNase 1 variants.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: November 1, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, George N. Phillips, Jr., R. Jeremy Johnson, Jason G. McCoy
  • Cytotoxic ribonuclease variants
    Patent number: 7655757
    Abstract: This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase 1 hRI complex. Also disclosed is the 3-D structure of the hRI.RNase 1 complex and methods for designing the RNase 1 variants.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: February 2, 2010
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, George N. Phillips, Jr., R. Jeremy Johnson, Jason G. McCoy
  • CYTOTOXIC RIBONUCLEASE VARIANTS
    Publication number: 20090311784
    Abstract: This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex. Also disclosed is the 3-D structure of the hRI•RNase 1 complex and methods for designing the RNase 1 variants.
    Type: Application
    Filed: July 2, 2009
    Publication date: December 17, 2009
    Inventors: Ronald T. Raines, George N. Phillips, JR., R. Jeremy Johnson, Jason G. McCoy