Abstract: Communication systems are described that use signal constellations, which have unequally spaced (i.e. ‘geometrically’ shaped) points. In many embodiments, the communication systems use specific geometric constellations that are capacity optimized at a specific SNR. In addition, ranges within which the constellation points of a capacity optimized constellation can be perturbed and are still likely to achieve a given percentage of the optimal capacity increase compared to a constellation that maximizes dmin, are also described. Capacity measures that are used in the selection of the location of constellation points include, but are not limited to, parallel decode (PD) capacity and joint capacity.

Abstract: Methods are provided for identifying Alzheimer's disease cells or subjects, based on the methylation status of multiple methylation markers in genomic DNA. Also provided are methods for identifying therapeutic agents for treating Alzheimer's disease by monitoring changes in the methylation status of multiple methylation markers.

Abstract: A pedestrian alerting system adapts alerting sounds emitted by a vehicle according to an acoustic environment around the vehicle. Echoes of the alerting sound in an enclosed space such as a garage can be irritating to the pedestrians and/or occupants of the vehicle. A sensor suite including radar, cameras, and/or a GPS locator detect confined spaces in which reflections result in a greater apparent loudness. Emitted loudness of the alerting sounds are reduced, wherein the reduction of the volume may be based on the size of the space.

Abstract: Communication systems are described that use unequally spaced constellations that have increased capacity compared to conventional constellations operating within a similar SNR band.

Abstract: Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method for manufacturing a microbiota restoration therapy composition may include collecting a human fecal sample and adding a diluent to the human fecal sample to form a diluted sample. The diluent may include a cryoprotectant. The method may also include mixing the diluted sample with a mixing apparatus and filtering the diluted sample. Filtering may form a filtrate. The method may also include transferring the filtrate to a sample bag and sealing the sample bag.

Abstract: In some examples, a device controls a heating, ventilation, and air conditioning (HVAC) system within a building. The device includes an analog display including a set of markers. Additionally, the devices includes processing circuitry configured to determine whether one or both of a cooling set point mode and a heating set point mode is activated and cause a set point to change from a first set point value to a second set point value in response to receiving a first rotation input to a dial. Additionally, the processing circuitry is configured to control a set of LEDs to transition from illuminating a first marker of the set of markers to illuminating a second marker of the set of markers, wherein the first marker corresponds to the first set point value and the second marker corresponds to the second set point value.

Abstract: A system may include a memory and a processor in communication therewith configured to perform operations. The operations may include receiving an audio file and a text file related to the audio file, analyzing the audio file to produce an analysis, and determining a portion of the audio file is similar to a segment of the text file. The operations may include identifying a first terminal signal and corresponding the first terminal signal to a first terminal tag in the text file such that the first terminal tag is aligned with the first terminal signal; the first terminal signal identifies a first portion terminal end of the portion and the first terminal tag identifies a first segment terminal end of the segment. The operations may include generating a converted text from the analysis and inserting the segment into the converted text.

Abstract: A pedestrian alerting system adapts alerting sounds emitted by a vehicle according to an acoustic environment around the vehicle. Echoes of the alerting sound in an enclosed space such as a garage can be irritating to the pedestrians and/or occupants of the vehicle. A sensor suite including radar, cameras, and/or a GPS locator detect confined spaces in which reflections result in a greater apparent loudness. Emitted loudness of the alerting sounds are reduced, wherein the reduction of the volume may be based on the size of the space.

Abstract: An example particle therapy system includes a gantry having a beamline structure configured to direct a particle beam that is monoenergetic from an output of a particle accelerator towards an irradiation target, where the beamline structure includes magnetic bending elements to bend the particle beam along a length of the beamline structure; and an energy degrader downstream of the beamline structure relative to the particle accelerator, where the energy degrader is configured and controllable to change an energy of the particle beam prior to at least part of the particle beam reaching the irradiation target.

Abstract: Prodrugs of antibiotic teixobactin, methods of their synthesis, and methods of their use as antimicrobial treatments are described. The teixobactin prodrugs incorporate one or more O-acyl linkages. The O-acyl linkages can be utilized in substitution of amide peptide bonds between an amino acid containing an alcohol side chain and the immediately preceding amino acid.

Abstract: A dispersion, methods of making the same, applications of the dispersion to graphitic material and the resulting coated particles are disclosed. The dispersion includes ?55% wt. coal tar pitch (softening point 100° C.-195° C.), ?60% wt. dispersant, and the balance a non-aromatic solvent such as water or alcohol. Pitch particles in the dispersion are preferably <10 ?m with a distribution of D50<15 ?m. The pitch particles are micronized, such as by dry and/or wet milling with the dispersant and aqueous solvent to achieve the desired pitch particle size and distribution. This aqueous dispersion may be mixed with natural or synthetic graphitic material having a diameter of 5-20 ?m in a ratio of 5%-30% pitch to graphite, dried and carbonized to form coated particles having a graphitic core at least partially coated by pitch particles.

Abstract: The present invention relates to a biocompatible, foldable, thin profile, low mass and high surface area, chitosan dressing, optionally modified with catechol, and suitable for treating bleeding in a physiological environment, e.g. bladder, and in particular in connection with the TURP procedure. The characteristics and structures of the chitosan dressing are provided. Methods of making and using the chitosan dressing are also provided.

Abstract: An example method includes: receiving, from a treatment planning process, information that is based on a dose distribution for an irradiation target; and performing at least one of the following operations: moving structures to trim spots of a particle beam so that the spots of the particle beam approximate pre-trimmed spots for which characteristics are obtained based on the information received; moving structures to produce a trimming curve for a layer of an irradiation target based on a specification of a trimming curve for the layer included in the information received; moving structures to produce a single trimming curve for all radiation fields of an irradiation target based on specifications of the single trimming curve included in the information received; or moving structures based on configuration information for the structures in the information received.

Abstract: Venous infusion catheter assemblies and methods of use are described herein. A catheter assembly may comprise an elongated body having a proximal end and a distal end, with an expandable occlusion element disposed on the elongated catheter body. A catheter may include a first infusion lumen extending to a proximal infusion port positioned on the catheter body proximally of the occlusion element and a second infusion lumen extending to a distal infusion port. Some embodiments may use a suction lumen extending to at least one suction port. When the catheter is introduced into vasculature of a patient, the suction port may be positioned in the patient's superior vena cava or right atrium to draw blood, the distal infusion port is positioned to direct normothermic or hyperthermic fluid toward the patient's heart, and the proximal infusion port is positioned to create a flow of hypothermic fluid in the patient's cerebral vasculature.

Abstract: Communication systems are described that use signal constellations, which have unequally spaced (i.e. ‘geometrically’ shaped) points. In many embodiments, the communication systems use specific geometric constellations that are capacity optimized at a specific SNR. In addition, ranges within which the constellation points of a capacity optimized constellation can be perturbed and are still likely to achieve a given percentage of the optimal capacity increase compared to a constellation that maximizes dmin, are also described. Capacity measures that are used in the selection of the location of constellation points include, but are not limited to, parallel decode (PD) capacity and joint capacity.

Abstract: A method of fabricating a component is described and involves retaining a canister as an integral part of the component after performing an isostatic pressing process. The method comprises: providing a canister having a canister wall that encloses an internal cavity, the canister wall comprising at least a first wall section and a second wall section, where the first wall section and the second wall section are of different materials; filling the internal cavity with a powdered material; performing an isostatic pressing process on the filled canister to consolidate the powder; and retaining the canister as an integral part of the component such that an internal structure of the component comprises the consolidated powder and the canister wall forms at least part of a surface of the component that covers the internal structure.

Abstract: Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method for manufacturing a microbiota restoration therapy composition may include collecting a human fecal sample and adding a diluent to the human fecal sample to form a diluted sample. The diluent may include a cryoprotectant. The method may also include mixing the diluted sample with a mixing apparatus and filtering the diluted sample. Filtering may form a filtrate. The method may also include transferring the filtrate to a sample bag and sealing the sample bag.