Patents by Inventor R. Keith Humphries

R. Keith Humphries has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nup98-Hox Fusions for Expansion of Hemopoietic Stem Cells
    Publication number: 20080299095
    Abstract: Nucleic acid constructs encoding homeobox-nucleoporin fusions are disclosed, compositions comprising same, and methods which provide enhanced expansion of stem cells. In particular, an isolated nucleic acid construct encoding a NUP98-HOX fusion is provided, which when introduced into hemopoietic stem cells provides enhanced expansion of these cells. Methods of expanding stem cells in vivo or ex vivo and methods of treatment using the stem cells are also described.
    Type: Application
    Filed: May 16, 2005
    Publication date: December 4, 2008
    Applicants: BC Cancer Agency, Universite de Montreal
    Inventors: R. Keith Humphries, Guy Sauvageau
  • Hox-induced enhancement of in vivo and in vitro proliferative capacity and gene therapeutic methods
    Patent number: 5837507
    Abstract: Stem cells transduced with HOXB4 exhibit enhanced in vitro and in vivo ability for self-regeneration and generate higher-numbers of tranplantable pluripotent hematopoietic stem cells relative to control and nonmanipulated cells.
    Type: Grant
    Filed: November 13, 1995
    Date of Patent: November 17, 1998
    Assignees: The Regents of the University of California, Keith Humphries, Guy Sauvageau
    Inventors: Corey Largman, Hugh Jeffrey Lawrence, R. Keith Humphries, Guy Sauvageau
  • Method of using CD24 as a cell marker
    Patent number: 5804177
    Abstract: A method of marking a cell involving introducing into the cell a nucleotide sequence encoding a cell surface protein and having substantial homology to the nucleotide sequence encoding CD24, and expressing the cell surface protein on the cell.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: September 8, 1998
    Inventor: R. Keith Humphries