Patents by Inventor R. L. Juliano

R. L. Juliano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the identification of peptides that recognize specific DNA sequences
    Patent number: 5869250
    Abstract: A method for identifying biologically significant peptide-DNA binding interactions and sequence-specific DNA-binding peptides in vivo using combinatorial oligonucleotide libraries is disclosed. Target DNA sequences include promoter sequences, 5' and 3' regulatory sequences, and exon and intron regulatory sequences. Preferably, a yeast combinatorial library is employed. Peptides that bind to specific DNA sequences, identified by the above method, are disclosed. Also disclosed is a method for identifying nontoxic compounds that inhibit gene expression in host cells in vivo.
    Type: Grant
    Filed: December 2, 1996
    Date of Patent: February 9, 1999
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Xiaojun Cheng, R. L. Juliano