Abstract: A pharmaceutical composition comprises (a) metronidazole in an antibacterially effective amount; and (b) an antifungal agent in an antifungally effective amount, illustratively comprising butoconazole or a pharmaceutically acceptable salt or ester thereof. The composition is adapted for application in a unit dose amount to a vulvovaginal surface and has at least one nonlipoidal internal phase and at least one lipoidal external phase that is bioadhesive to the vulvovaginal surface. The composition is useful for administration to a vulvovaginal surface to treat a mixed bacterial vaginosis and vulvovaginal candidiasis infection.

Abstract: A pharmaceutical composition comprises a first active (e.g., antibacterial) agent and a second (e.g., antifungal) active agent, and comprises a component that is adapted for bioadhesion to a vulvovaginal surface. The composition provides differential release of the active agents at such a surface, wherein the second active agent exhibits a release profile that is substantially delayed, extended and/or inverted relative to the release profile of the first active agent.

Abstract: A method for preventing stenosis and thrombosis of an AV graft is disclosed. An essential fatty acid emulsion is administered to the patient through the AV graft, preferably during dialysis, whereby the anti-inflammatory properties of the essential fatty acid emulsion prevent complications typical of AV grafts.

Abstract: This invention is directed generally to modified-release pharmaceutical compositions, and, more particularly, to modified-release anesthetic- or analgesic-comprising pharmaceutical compositions that are bioadherent to a vaginal cavity surface, vulva surface, or skin. This invention also is directed generally to methods for preparing such compositions, methods of treatment using such compositions, uses of such compositions to prepare medicaments, and kits comprising such compositions.

Abstract: A pharmaceutical composition comprises (a) an antibacterial agent in an antibacterially effective amount, illustratively comprising clindamycin or a pharmaceutically acceptable salt or ester thereof, and (b) an antifungal agent in an antifungally effective amount, illustratively comprising butoconazole or a pharmaceutically acceptable salt or ester thereof. The composition is adapted for application in a unit dose amount to a vulvovaginal surface and has at least one nonlipoidal internal phase and at least one lipoidal external phase that is bioadhesive to the vulvovaginal surface. The composition is useful for administration to a vulvovaginal surface to treat a mixed bacterial vaginosis and vulvovaginal candidiasis infection.

Abstract: The present invention relates to methods of treatment vulvovaginitis caused by nonspecified Candida isolates using controlled release antimycotic delivery systems. The invention utilizes a minimal number of administrations to obtain cessation of the condition. The methods and systems are especially effective against any Candida species causing vaginal irritation, and thus reduce the need for identification of the isolate prior to treatment.

Abstract: The present disclosure relates to novel compositions which provide improved nutritional support for premenopausal and menopausal women and/or relief from systems associated with menopause, as well as prophylactic effects, and methods for using same.

Abstract: The present disclosure relates to novel nutritional methods and compositions containing essential fatty acids which optimize embryonic, fetal and child neurological development and provide improved nutritional support for women prior to and during lactation. Further the methods and compositions improve gestational length and birth weight. The nutritional methods and compositions are also intended for use by women to optimize infant neurological development and provide improved nutritional support for women prior to, during and after lactation.

Abstract: A pharmaceutical formulation to treat vaginal conditions in a human patient comprises: at least one active agent; a modified release dosage form which provides extended release of the anti-infective agent upon vaginal administration to the patient; and wherein the formulation, when containing a total dose of the anti-infective agent of about 25 ?g to about 500 mg based on the active agent will produce a plasma concentration versus time curve (ng/mL versus hours) having an area under the curve (AUC) of less than about 600 ng/mL.hr.

Abstract: This invention relates to novel nutritional supplements comprising essential fatty acids and iron, as well as methods related thereto.

Abstract: A stackable, lightweight water dispenser bottle and method of using a plurality of such bottles in conjunction with a conventional water cooler is disclosed. The bottle comprises a generally parallelepipedal container body with rounded edges and corners with a plurality of dimples in a top portion and complementarily shaped protuberances on a bottom portion. The top portion has a central depression therein with a round hole surrounded by a cylindrical collar sealed by a screw-on cap. A neck portion rising from a central depression in the bottom portion terminates in an opening communicating with the interior of the container body and is sealed with a plastic cap after the water bottle is filled. A first such water bottle can be inverted and sealingly inserted into the opening at the top of a water cooler to partially fill the cooler.

Abstract: Lignosulfonates are incorporated in photographic developing compositions containing an indazole antifoggant in order to prevent or retard the precipitation of the indazole. Both black-and-white developing compositions, containing such developing agents as dihydroxybenzenes and/or pyrazolidones, and color developing compositions, containing primary aromatic amino color developing agents, are effectively stabilized against precipitation of indazole antifoggants by the lignosulfonates.

Abstract: A heat bleachable material comprises (i) at least one hexaarylbiimidazole with (ii) at least one dye, especially an antihalation or filter dye, that is reactive with the product of the hexaarylbiimidazole formed upon heating the material to a temperature above about 90.degree. C. This provides a material that becomes at least 40% colorless within about 20 minutes, typically within about 30 seconds, upon heating to a temperature as described. The dye-containing material is especially useful for antihalation and filter purposes in a photographic element. The material can be a heat bleachable dye layer of a photothermographic element. The heat bleachable dye layer can also be useful in a thermographic element.

Abstract: A photothermographic element can comprise a support and on the support or in the support an antihalation or filter component that comprises a heat bleachable material comprising (i) at least one hexaarylbiimidazole with (ii) at least one dye, especially an antihalation or filter dye, that is reactive with the product of the hexaarylbiimidazole formed upon heating the material to a temperature above about 90.degree. C. This provides an antihalation or filter material that becomes at least 40% colorless within about 20 minutes, typically within about 30 seconds, upon heating to a temperature as described. The antihalation or filter material can be a heat bleachable dye layer of a photothermographic element.

Abstract: A combined cutting and vacuum apparatus comprising a cutting device having a vacuum shroud and a remote housing having a vacuum motor disposed therein. A flexible drive shaft powers the cutting device from the motor and a flexible vacuum tube produces a vacuum at the shroud. The motor includes a rotary drive shaft having a first end portion on which an impeller is secured and to which the flexible drive shaft is connected. A vacuum chamber is provided in the housing over the impeller and the rotary shaft extends therethrough. The vacuum chamber has an inlet port laterally offset from the rotary shaft. A removable filter bag is mounted within the housing between the port and the vacuum tube.In one embodiment the cutting device includes a handpiece having a rotary bur. The shroud is a tubular member having a flared open mouth. The handpiece is releasably secured within the shroud, with the abrading bur extending from the interior of the shroud to slightly outside the flared mouth.