Patents by Inventor R. Manjunatha Kini

R. Manjunatha Kini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11266710
    Abstract: This disclosure provides methods of a method of treating a retinal angiogenic in a subject comprising administering an effective amount of an Angio-3 peptide.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: March 8, 2022
    Assignee: Singapore Health Services Pte Ltd.
    Inventors: Michael Belkin, Veluchamy Amutha Barathi, Rajamani Lakshminarayanan, R. Manjunatha Kini, Ge Ruowen, Tien Yin Wong, Gemmy Chui Ming Cheung
  • Patent number: 10906946
    Abstract: The present invention provides isolated peptides, variants and fragments thereof that are capable of binding with a high level of specificity to thrombin and inhibiting its activity. There is also provided uses of such peptides in methods of diagnosis and treatment, coating of medical devices and nucleic acids encoding the same.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: February 2, 2021
    Assignees: National University of Singapore, Institute of Zoology, Slovak Academy of Sciences
    Inventors: Janaki Krishnamoorthy Iyer, Cho Yeow Koh, R. Manjunatha Kini, Maria Kazimirova, Ladislav Roller
  • Publication number: 20200246417
    Abstract: This disclosure provides methods of a method of treating a retinal angiogenic in a subject comprising administering an effective amount of an Angio-3 peptide.
    Type: Application
    Filed: August 31, 2018
    Publication date: August 6, 2020
    Inventors: Michael BELKIN, Veluchamy Amutha BARATHI, Rajamani LAKSHMINARAYANAN, R. Manjunatha KINI, Ge RUOWEN, Tien Yin WONG, Gemmy Chui Ming CHEUNG
  • Publication number: 20190002511
    Abstract: The present invention provides isolated peptides, variants and fragments thereof that are capable of binding with a high level of specificity to thrombin and inhibiting its activity. There is also provided uses of such peptides in methods of diagnosis and treatment, coating of medical devices and nucleic acids encoding the same.
    Type: Application
    Filed: June 17, 2016
    Publication date: January 3, 2019
    Applicants: National University of Singapore, Institute of Zoology, Slovak Academy of Sciences
    Inventors: Janaki Krishnamoorthy IYER, Cho Yeow KOH, R. Manjunatha KINI, Maria KAZIMIROVA, Ladislav ROLLER
  • Patent number: 9217027
    Abstract: The invention relates to thrombin inhibitors derived from the salivary glands of haematophagous arthropods and in particular to bivalent and trivalent thrombin inhibitors that act by interacting with thrombin at two or three different sites.
    Type: Grant
    Filed: June 18, 2008
    Date of Patent: December 22, 2015
    Assignee: Isis Innovation Limited
    Inventors: Maria Kazimtrova, R. Manjunatha Kini, Cho Yeow Koh
  • Publication number: 20130183237
    Abstract: The invention relates to thrombin inhibitors derived from the salivary glands of haematophagous arthropods and in particular to bivalent and trivalent thrombin inhibitors that act by interacting with thrombin at two or three different sites.
    Type: Application
    Filed: June 18, 2008
    Publication date: July 18, 2013
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Maria Kazimirova, R. Manjunatha Kini, Cho Yeow Koh
  • Publication number: 20120135931
    Abstract: The present invention relates to a method of modifying serine protease inhibitors in order to acquire or enhance any one of a variety of desired properties, including extent of inhibition, maintenance of inhibition following cleavage of the serine protease inhibitor by the target serine protease, speed of binding to the serine protease, neutralisation, and binding affinity. The present invention also relates to the products of such modifications and the uses of such products, in particular, their use in therapy.
    Type: Application
    Filed: May 5, 2010
    Publication date: May 31, 2012
    Applicant: NATURAL ENVIRONMENT RESEARCH COUNCIL
    Inventors: R. Manjunatha Kini, Cho Yeow Koh, Kunchithapadam Swaminathan, Kumar Sundramurthy
  • Patent number: 7317003
    Abstract: The present invention provides peptides having potent anti-angiogenic activity and endothelial cell proliferation inhibition activity. The peptides can be administered as pharmaceutical compositions for prevention or treatment of undesired angiogenesis, for instance for prevention of tumor metastasis or inhibition of primary tumor growth.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: January 8, 2008
    Assignee: National University of Singapore
    Inventors: Ruowen Ge, R. Manjunatha Kini
  • Patent number: 6613745
    Abstract: The present invention relates generally to peptide molecules and to derivatives, homologues, analogues and mimetics thereof capable of inducing or facilitating analgesia or partial analgesia alone or in combination with other analgesic molecules. The present invention also contemplates a method of inducing or facilitating analgesia or partial analgesia by the administration of a peptide or a derivative, homologue, analogue or mimetic thereof. The amino acid sequence of the peptide molecules of the present invention are derived from or based on amino acid sequences of snake venom toxins, and, in particular, &agr;-neurotoxins.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: September 2, 2003
    Assignee: National University of Singapore
    Inventors: Ponnampalam Gopalakrishnakone, Xiao Chun Pu, Peter Tsun-Hon Wong, Mathew Choon Eng Gwee, R. Manjunatha Kini
  • Publication number: 20020103129
    Abstract: The present invention provides peptides having potent anti-angiogenic activity and endothelial cell proliferation inhibition activity. The peptides can be administered as pharmaceutical compositions for prevention or treatment of undesired angiogenesis, for instance for prevention of tumor metastasis or inhibition of primary tumor growth.
    Type: Application
    Filed: January 22, 2001
    Publication date: August 1, 2002
    Inventors: Ruowen Ge, R. Manjunatha Kini
  • Patent number: 6258550
    Abstract: Among other things, methods of obtaining putative protein-protein interaction sites of biologically-active polypeptides are provided. The methods include searching the polypeptides for a regions that are flanked on each termini by at least one proline residue; and isolating or producing the flanked regions.
    Type: Grant
    Filed: October 6, 1999
    Date of Patent: July 10, 2001
    Assignee: Virginia Commonwealth University
    Inventors: Herbert J. Evans, R. Manjunatha Kini
  • Patent number: 6200954
    Abstract: The present invention provides peptides having potent anti-angiogenic activity. The peptides can be administered as pharmaceutical compositions for prevention or treatment of undesired angiogenesis, for instance for prevention of tumor metastasis or inhibition of primary tumor growth.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: March 13, 2001
    Assignee: National University of Singapore
    Inventors: Ruowen Ge, R. Manjunatha Kini
  • Patent number: 6147189
    Abstract: Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: November 14, 2000
    Assignee: Virginia Commonwealth University
    Inventors: Herbert J. Evans, R. Manjunatha Kini
  • Patent number: 6111069
    Abstract: Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: August 29, 2000
    Assignee: Virginia Commonwealth University
    Inventors: Herbert J. Evans, R. Manjunatha Kini
  • Patent number: 6100044
    Abstract: Homologs and analogs of naturally occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are identified by the presence of flanking conformation-constraining moieties, such as proline or cysteine.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: August 8, 2000
    Assignee: Virginia Commonwealth University
    Inventors: Herbert J. Evans, R. Manjunatha Kini
  • Patent number: 6084066
    Abstract: Homologs and analogs of naturally-occurring stem cell factor polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: July 4, 2000
    Assignee: Virginia Commonwealth University
    Inventors: Herbert J. Evans, R. Manjunatha Kini
  • Patent number: 5965698
    Abstract: Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.
    Type: Grant
    Filed: May 3, 1996
    Date of Patent: October 12, 1999
    Assignee: Virginia Commonwealth University
    Inventors: Herbert J. Evans, R. Manjunatha Kini
  • Patent number: 5952465
    Abstract: The present invention relates to method of producing a conformationally-constrained polypeptide that mimics the activity of an immunomodulator peptide, wherein the method comprises: producing the conformationally-constrained polypeptide, wherein the conformationally-constrained polypeptide contains a protein--protein interaction site of said immunomodulator peptide adjacently flanked on both termini by proline residues in a manner distinct from the manner found in the naturally occurring immunomodulator peptide.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: September 14, 1999
    Assignee: Virginia Commonwealth University
    Inventors: Herbert J. Evans, R. Manjunatha Kini
  • Patent number: 5948887
    Abstract: Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: September 7, 1999
    Assignee: Virginia Commonwealth University
    Inventors: Herbert J. Evans, R. Manjunatha Kini
  • Patent number: 5928896
    Abstract: Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: July 27, 1999
    Assignee: Virginia Commonwealth University
    Inventors: Herbert J. Evans, R. Manjunatha Kini