Patents by Inventor R. Martin Emanuele

R. Martin Emanuele has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiinfective polyoxypropylene/polyoxyethylene copolymers and methods of use
    Patent number: 5674911
    Abstract: The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but substantially reduce the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable and the cardiotoxicity inherent in the native copolymers is substantially reduced.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 7, 1997
    Assignee: Cytrx Corporation
    Inventors: R. Martin Emanuele, Mannarsamy Balasubramanian, Hameedsulthan S. Allaudeen
  • Methods and compositions for reducing multidrug resistance
    Patent number: 5591715
    Abstract: The present invention comprises methods and compositions for reducing or eliminating multidrug resistance in cancers or certain infections by drug resistant microorganisms in patients. According to the method and composition of the present invention, a non-ionic amphipathic diester of fatty acids or a reverse poloxmer is administered to a patient in which a cancer or microorganism exhibits multidrug resistance to the chemotherapeutic agent. The method and composition of the present invention may be employed with particular efficacy where multidrug resistance to any chemotherapeutic agent has been conferred upon a cancer.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 7, 1997
    Assignee: Rush Presbyterian-St. Luke's Medical Center
    Inventors: John S. Coon, Mannarsamy Balasubramanian, R. Martin Emanuele, Himanshu Shah
  • Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
    Patent number: 5567859
    Abstract: The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but substantially reduce the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable and the cardiotoxicity inherent in the native copolymers is substantially reduced.
    Type: Grant
    Filed: August 9, 1994
    Date of Patent: October 22, 1996
    Assignee: CytRx Corporation
    Inventors: R. Martin Emanuele, Mannarsamy Balasubramanian, Hameedsulthan S. Allaudeen
  • Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
    Patent number: 5523492
    Abstract: The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.
    Type: Grant
    Filed: July 2, 1993
    Date of Patent: June 4, 1996
    Assignee: CYTRX Corporation
    Inventors: R. Martin Emanuele, Robert L. Hunter, Paula H. Culbreth
  • Method for inhibiting microbial binding to surfaces
    Patent number: 5494660
    Abstract: A new class of biologically-active copolymers is provided capable of affecting biological systems in many different ways. The biologically-active copolymers of the present invention also have a wide variety of effects on individual cells. The biologically-active copolymers are also effective against certain microorganisms. The biologically active copolymers of the present invention can be administered to animals to provide specific effects on certain microorganisms that reside in the gut of the animal. A preferred use is administering the biologically active copolymers of the present invention to poultry to reduce the number of Salmonella in the poultry gut. Another preferred use is treatment of surfaces to interfere with the adhesion of microorganisms to the surfaces.
    Type: Grant
    Filed: February 9, 1994
    Date of Patent: February 27, 1996
    Assignees: Emory University, Cytrx Corporation
    Inventors: Robert L. Hunter, R. Martin Emanuele, Robert H. Carpenter
  • Gel composition for implant prosthesis and method of use
    Patent number: 5407445
    Abstract: In accordance with the present invention, a composition and method is provided for a biocompatible filler for prostheses. The composition and method relate to certain polyoxyethylene/polyoxypropylene block copolymers which have gelling properties at body temperature and are ideally suited for use as fillers for a soft tissue prosthesis such as a breast implant.
    Type: Grant
    Filed: May 19, 1993
    Date of Patent: April 18, 1995
    Assignee: Cytrx Corporation
    Inventors: Daiva K. Tautvydas, Mannarsamy Balasubramanian, R. Martin Emanuele