Patents by Inventor R. Michael van Dam
R. Michael van Dam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160107951Abstract: Disclosed herein are methods of performing microchemical reactions and electro-wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing 18F.Type: ApplicationFiled: October 9, 2015Publication date: April 21, 2016Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: R. Michael Van Dam, Chang-Jin Kim, Supin Chen, Huijiang Ding, Gaurav Jitendra Shah, Pei Yuin Keng
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Patent number: 9211520Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures.Type: GrantFiled: December 24, 2014Date of Patent: December 15, 2015Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael Van Dam, Sebastian Olma, Dirk Williams, Mark Eddings, Clifton Kwang-Fu Shen
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Patent number: 9193640Abstract: Disclosed herein are methods of performing microchemical reactions and electro-wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing 18F.Type: GrantFiled: March 10, 2015Date of Patent: November 24, 2015Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: R. Michael Van Dam, Chang-Jin Kim, Supin Chen, Huijiang Ding, Gaurav Jitendra Shah, Pei Yuin Keng
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Publication number: 20150329583Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures.Type: ApplicationFiled: December 24, 2014Publication date: November 19, 2015Inventors: Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael Van Dam, Sebastian Olma, Dirk Williams, Mark Eddings, Clifton Kwang-Fu Shen
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Patent number: 9138700Abstract: The invention may provide a microfluidic mixer having a droplet generator and a droplet mixer in selective fluid connection with the droplet generator. The droplet generator comprises first and second fluid chambers that are structured to be filled with respective first and second fluids that can each be held in isolation for a selectable period of time. The first and second fluid chambers are further structured to be reconfigured into a single combined chamber to allow the first and second fluids in the first and second fluid chambers to come into fluid contact with each other in the combined chamber for a selectable period of time prior to being brought into the droplet mixer.Type: GrantFiled: January 21, 2009Date of Patent: September 22, 2015Assignee: The Regents of the University of CaliforniaInventors: R. Michael Van Dam, Kan Liu, Kwang-Fu Clifton Shen, Hsian-Rong Tseng
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Publication number: 20150203416Abstract: Disclosed herein are methods of performing microchemical reactions and electro-wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing 18F.Type: ApplicationFiled: March 10, 2015Publication date: July 23, 2015Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: R. Michael Van Dam, Chang-Jin Kim, Supin Chen, Huijiang Ding, Gaurav Jitendra Shah, Pei Yuin Keng
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Publication number: 20150148549Abstract: The present disclosure sets forth incorporating microfluidic chips Interfaces for use with digital microfluidic processes. Methods and devices according to the present disclosure utilize compact, integrated platforms that interface with a chip upstream and downstream of the reaction, as well as between intermediate reaction steps if needed. In some embodiments these interfaces are automated, including automation of a multiple reagent process. Various reagent delivery systems and methods are also disclosed.Type: ApplicationFiled: June 10, 2013Publication date: May 28, 2015Inventors: R. Michael Van Dam, Gaurav Shah, Pei-Yuin Keng
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Patent number: 9005544Abstract: Disclosed herein are methods of performing microchemical reactions and electro-wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing 18F.Type: GrantFiled: October 15, 2010Date of Patent: April 14, 2015Assignee: The Regents of the University of CaliforniaInventors: R. Michael Van Dam, Chang-Jin Kim, Supin Chen, Huijiang Ding, Gaurav Jitendra Shah, Pei Yuin Keng
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Patent number: 8951480Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures.Type: GrantFiled: August 19, 2009Date of Patent: February 10, 2015Assignee: The Regents of the University of CaliforniaInventors: Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael Van Dam, Sebastian Olma, Dirk Williams, Mark A. Eddings, Clifton Kwang-Fu Shen
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Patent number: 8658112Abstract: Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.Type: GrantFiled: November 1, 2011Date of Patent: February 25, 2014Assignees: Siemens Medical Solutions USA, Inc., California Institute of TechnologyInventors: Arkadij M. Elizarov, Hartmuth C. Kolb, R. Michael Van Dam, James R. Heath
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Publication number: 20120264932Abstract: Disclosed herein are methods of performing microchemical reactions and electro- wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing 18F.Type: ApplicationFiled: October 15, 2010Publication date: October 18, 2012Inventors: R. Michael Van Dam, Chang-Jin Kim, Supin Chen, Huijiang Ding, Gaurav Jitendra Shah, Pei Yuin Keng
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Patent number: 8173073Abstract: Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.Type: GrantFiled: October 29, 2010Date of Patent: May 8, 2012Assignee: Siemens Medical Solutions USA, Inc.Inventors: Arkadij M. Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth C. Kolb, R. Michael Van Dam, Lawrence Diener, Sean Ford, Reza Miraghaie
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Publication number: 20120107175Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures.Type: ApplicationFiled: August 19, 2009Publication date: May 3, 2012Applicant: The Regents of the Univeristy of CaliforniaInventors: Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael Van Dam, Sebastian Olma, Dirk Williams, Mark A. Eddings, Clifton Kwang-Fu Shen
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Publication number: 20120101268Abstract: Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.Type: ApplicationFiled: November 1, 2011Publication date: April 26, 2012Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.Inventors: Arkadij M. Elizarov, Hartmuth C. Kolb, R. Michael Van Dam, James R. Heath
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Patent number: 8075851Abstract: Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.Type: GrantFiled: September 29, 2006Date of Patent: December 13, 2011Assignees: Siemens Medical Solutions USA, Inc., California Institute of TechnologyInventors: Arkadij M Elizarov, Hartmuth C. Kolb, R. Michael Van Dam, James R. Heath
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Patent number: 8071035Abstract: Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.Type: GrantFiled: April 14, 2008Date of Patent: December 6, 2011Assignee: Siemens Medical Solutions USA, Inc.Inventors: Arkadij M Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth C. Kolb, R. Michael Van Dam, Lawrence Talcott Diener, Sean Ford, Reza Miraghaie
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Publication number: 20110103176Abstract: The invention may provide a microfluidic mixer having a droplet generator and a droplet mixer in selective fluid connection with the droplet generator. The droplet generator comprises first and second fluid chambers that are structured to be filled with respective first and second fluids that can each be held in isolation for a selectable period of time. The first and second fluid chambers are further structured to be reconfigured into a single combined chamber to allow the first and second fluids in the first and second fluid chambers to come into fluid contact with each other in the combined chamber for a selectable period of time prior to being brought into the droplet mixer.Type: ApplicationFiled: January 21, 2009Publication date: May 5, 2011Applicant: The Regents of the University of CaliforniaInventors: R. Michael Van Dam, Kan Liu, Kwang-Fu Clifton Shen, Hsian-Rong Tseng
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Publication number: 20110097245Abstract: Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.Type: ApplicationFiled: October 29, 2010Publication date: April 28, 2011Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.Inventors: Arkadij M. Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth C. Kolb, R. Michael Van Dam, Lawrence Diener, Sean Ford, Reza Miraghaie
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Publication number: 20090095635Abstract: Methods and apparatus enable radiosynthesis of radiolabeled compounds using electrochemical trapping and release. The trapping and release of radioactive isotopes all occur inside a microreactor, a vial or similar device, thus eliminating the need for azeotropic drying and several dead-end filling steps, as well as the necessity to move concentrated radioisotopes from one compartment of the chip to another. These and other features allow radioisotope enrichment to be carried out internally within a radiochemical synthesis chip, providing faster and more robust operation, as well as producing very high radiochemical labeling yields.Type: ApplicationFiled: July 18, 2008Publication date: April 16, 2009Inventors: Arkadij M. Elizarov, Hartmuth C. Kolb, R. Michael van Dam, James R. Heath, Brian Edgecombe, Farshad Motamedi, Anthony Stephen, Michael A. Giardello
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Publication number: 20090036668Abstract: Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.Type: ApplicationFiled: April 14, 2008Publication date: February 5, 2009Inventors: Arkadij M. Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth Kolb, R. Michael van Dam, Lawrence Talcott Diener, Sean Ford, Reza Miraghaie