Abstract: The disclosure features lipid nanoparticle (LNP) compositions comprising mRNA molecules encoding human granulocyte macrophage colony stimulating factor (GM-CSF) polypeptides and uses thereof in the treatment of Parkinson's Disease. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding human GM-CSF for use in such treatment.

Abstract: An instrument for testing fluid characteristics has a vial and a housing. The vial defines a chamber for receiving a sample of the fluid and has a cap for sealing the fluid therein. The housing defines a recess for receiving the vial. Multiple light emitting diodes and photovoltaic detectors are arranged on multiple meridional planes within the housing. The meridional planes each intersect approximately at a central axis of the chamber when the vial is placed within the recess. Modulation of the light emitting diodes and tuned processing electronics allow for simultaneous evaluation of sample characteristics such as spectral transmittance, turbidity and fluorescence. The user selects particular tests via a keypad and a display indicates the results of the chosen analysis.

Abstract: The present invention is embodied in an ink well assembly for use with a transfer pad or tampon printing machine having a image plate. The ink well assembly of the present invention includes an ink reservoir for holding ink, a receiving area for securing the image plate in a sealed relationship with the ink, a plurality of adjusters for securely urging the image plate within the receiving area, and a plurality of fasteners unexposed to the ink. The unexposed fasteners secure component parts without exposing the fasteners to the ink to allow easy set up, cleaning, disassembly and reassembly, elimination of ink leaks, and incorporation with the pad printing machine without significant machine downtime.

Abstract: A furnace delining apparatus has a telescopic jib mounted about a horizontal pivot axis on a turntable. The distal end of the jib carries a tool on a carrier swingable about an axis transverse to the jib axis. The carrier is pivotally mounted on a jib extension which can be rotated about its longitudinal axis to selected positions which are defined by locating means on the jib. The extension is permanently mounted for rotation on a spigot projecting axially from the jib and is axially slidable between a position in engagement with the locating means and a free position in which it can be rotated to a new angular position.