Patents by Inventor Rêmy Hallet

Rêmy Hallet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vitro generation of dendritic cells by exposure to an anti-CSF1-R antibody
    Patent number: 9676859
    Abstract: The invention is generally directed to promoting dendritic cells (DCs), and optionally M1-type (macrophage M1 polarization), immune response by administering a compound that modulates macrophage polarization. The invention is directed to the use of an antibody able to bind to CSF-1R for modulating macrophage polarization. The invention is also directed to methods for evaluating the dose efficacy of an antibody able to bind to CSF-1R in a patient by assessing the in vivo or in vitro polarization of macrophages. The invention is further directed to post-treatment companion test and assays to assess the effect of an antibody able to bind to CSF-1R on a subject being treated.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: June 13, 2017
    Assignee: Transgene SA
    Inventors: Hélène Haegel, Rémy Hallet
  • Method for increasing M1 macrophages in a patient
    Patent number: 9139652
    Abstract: The invention is generally directed to promoting M1-type (macrophage M1 polarization) immune response by administering a compound that modulates macrophage activation. The invention is directed to the use of an antibody able to bind to CSF-IR for modulating macrophage activation. The invention is also directed to methods for evaluating the dose efficacy of an antibody able to bind to CSF-IR in a patient by assessing the in vivo or in vitro activation of macrophages. The invention is further directed to post-treatment companion test and assays to assess the effect of an antibody able to bind to CSF-IR on a subject being treated.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: September 22, 2015
    Assignee: Transgene SA
    Inventors: Hélène Haegel, Rêmy Hallet
  • Modulation of Monocytes, or Precursors Thereof, Differentiation
    Publication number: 20150252115
    Abstract: The invention is generally directed to promoting dendritic cells (DCs), and optionally M1-type (macrophage M1 polarization), immune response by administering a compound that modulates macrophage polarization. The invention is directed to the use of an antibody able to bind to CSF-1R for modulating macrophage polarization. The invention is also directed to methods for evaluating the dose efficacy of an antibody able to bind to CSF-1R in a patient by assessing the in vivo or in vitro polarization of macrophages. The invention is further directed to post-treatment companion test and assays to assess the effect of an antibody able to bind to CSF-1R on a subject being treated.
    Type: Application
    Filed: November 8, 2013
    Publication date: September 10, 2015
    Inventors: Hélène Haegel, Rémy Hallet
  • MODULATION OF MACROPHAGE ACTIVATION
    Publication number: 20140255417
    Abstract: The invention is generally directed to promoting M1-type (macrophage M1 polarization) immune response by administering a compound that modulates macrophage activation. The invention is directed to the use of an antibody able to bind to CSF-IR for modulating macrophage activation. The invention is also directed to methods for evaluating the dose efficacy of an antibody able to bind to CSF-IR in a patient by assessing the in vivo or in vitro activation of macrophages. The invention is further directed to post-treatment companion test and assays to assess the effect of an antibody able to bind to CSF-IR on a subject being treated.
    Type: Application
    Filed: October 19, 2012
    Publication date: September 11, 2014
    Inventors: Hélène Haegel, Rêmy Hallet