Patents by Inventor R. O'Bleness

R. O'Bleness has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12384820
    Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
    Type: Grant
    Filed: April 19, 2022
    Date of Patent: August 12, 2025
    Assignees: University of Louisville Research Foundation, Inc., University of Pittsburgh—Of the Commonwealth System of Higher Education, The United States of America, As represented by the Secretary, Department of Health and Human Services
    Inventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
  • Patent number: 12386637
    Abstract: Various embodiments of the present invention disclose techniques for orchestrating a complex data processing scheme for an investigative process using a machine-learning based orchestration model that is trained to optimize the use of computing resources based at least in part on a feedback loop. An input data object associated with an investigative process can be selected for investigation; a predictive data analysis sub-routine for processing the input data object can be intelligently selected from a plurality of predictive data analysis sub-routines by the machine-learning based orchestration model; and a processing orchestration action can be initiated based at least in part on an investigative score output by the predictive data analysis sub-routine. The processing orchestration action can include closing the input data object, continuing to process the input data object with additional predictive data analysis sub-routines, or passing the input data object to a predictive entity for further processing.
    Type: Grant
    Filed: October 4, 2022
    Date of Patent: August 12, 2025
    Assignee: Optum Services (Ireland) Limited
    Inventors: Kevin Larkin, Mark Tonge, Anthony R. O'Neill, Conor Breen, Peter Cogan
  • Patent number: 12331296
    Abstract: Provided herein are RNAi molecules for treating Huntington's disease. Further provided herein are expression cassettes, vectors (e.g., rAAV, recombinant adenoviral, recombinant lentiviral, and recombinant HSV vectors), cells, viral particles, and pharmaceutical compositions containing the RNAi. Yet further provided herein are methods and kits related to the use of the RNAi, for example, to treat Huntington's disease.
    Type: Grant
    Filed: February 15, 2023
    Date of Patent: June 17, 2025
    Assignee: Genzyme Corporation
    Inventors: Catherine R. O'Riordan, Adam Palermo, Brenda Richards, Lisa M. Stanek
  • Publication number: 20250171744
    Abstract: Disclosed herein are methods for reprogramming a somatic cell into a pluripotent stem cell by contacting the somatic cell with one or more antifolate agents, with or without methionine, in vitro for a period of time sufficient to reprogramming the somatic cell and selecting and growing the cells that express one or more stem cell markers. Also disclosed are induced pluripotent stem cells obtained from somatic cells.
    Type: Application
    Filed: November 26, 2024
    Publication date: May 29, 2025
    Applicant: CITY OF HOPE
    Inventors: Arthur D. RIGGS, Avinash C. SRIVASTAVA, Timothy R. O'CONNOR
  • Patent number: 12264699
    Abstract: A device which is attachable to a fastener stack, the device comprising: an attachment element made of shape memory material; and a cap comprising a base having an aperture and a shell having an interior space in fluid communication with the opening, wherein the base supports the shell and is coupled to the attachment element.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: April 1, 2025
    Assignee: The Boeing Company
    Inventors: Christopher S. Roper, Mark R. O'Masta, Haftom Y. Dessalegn
  • Publication number: 20250065158
    Abstract: A safe access system, comprising: a main body configured to attach to mounting hardware on a structure to be accessed; a first connector attached to the main body and configured for connecting to a vertical lifeline; and a second connector attached to the main body and configured for connecting to a power ascender line.
    Type: Application
    Filed: July 5, 2023
    Publication date: February 27, 2025
    Inventors: Sheri R. O'Dell, Joseph F. Deuer
  • Publication number: 20250062326
    Abstract: A lithium-ion battery may include a cathode, an anode, and a polymer electrolyte. The anode may include a current collector. A patterned lithium storage structure may overlay a patterned current collector. The patterned lithium storage structure may include first regions of a lithium storage material characterized by a first pattern. The patterned current collector may include second regions of recessed portions characterized by a second pattern complementary to the first pattern. The lithium storage material may include at least 40 atomic % amorphous silicon. These and other anodes and lithium-ion batteries are described.
    Type: Application
    Filed: November 1, 2024
    Publication date: February 20, 2025
    Applicant: Graphenix Development, Inc.
    Inventors: Terrence R. O'Toole, John C. Brewer, Paul D. Garman, Robert G. Anstey
  • Publication number: 20250062316
    Abstract: An anode for an energy storage device includes a current collector having an electrically conductive layer, a first surface characterized by a first pattern, and a second surface characterized by a complementary second pattern. The anode further includes a patterned lithium storage structure comprising a continuous porous lithium storage layer disposed over the current collector in a pattern corresponding to the first pattern. A method of making an anode for use in an energy storage device includes providing a current collector having an electrically conductive layer, a first surface characterized by a first pattern, and a second surface characterized by a complementary second pattern. A continuous porous lithium storage layer is formed by chemical vapor deposition over the first surface by exposing the current collector to a lithium storage material precursor gas.
    Type: Application
    Filed: December 17, 2021
    Publication date: February 20, 2025
    Applicant: GRAPHENIX DEVELOPMENT, INC.
    Inventors: Terrence R. O'Toole, John C. Brewer, Paul D. Garman, Robert G. Anstey, Kevin Tanzil
  • Publication number: 20240423381
    Abstract: A topper (38) for a bed extends in longitudinal and lateral directions and includes a fluid flowpath (60) for channeling fluid through the topper from an inlet (62) to an outlet (64). The flowpath is configured to distribute the fluid to a preferred target region (50) of the topper. A bed which includes the topper has a blower (72) connected to the topper inlet for supplying air (88) to the flowpath.
    Type: Application
    Filed: September 5, 2024
    Publication date: December 26, 2024
    Inventors: Charles A. Lachenbruch (Deceased), Rachel L. Williamson, Timothy J. Receveur, Christopher R. O'Keefe
  • Patent number: 12166200
    Abstract: A lithium-ion battery may include a cathode, an anode, and a polymer electrolyte. The anode may include a current collector. The current collector may include a metal oxide layer provided in a first pattern overlaying a metal layer. The anode may also include a patterned lithium storage structure. The patterned lithium storage structure may include a continuous porous lithium storage layer overlaying at least a portion of the first pattern of metal oxide. These and other lithium-ion batteries are described.
    Type: Grant
    Filed: October 27, 2022
    Date of Patent: December 10, 2024
    Assignee: Graphenix Development, Inc.
    Inventors: Terrence R. O'Toole, John C. Brewer, Paul D. Garman, Robert G. Anstey
  • Publication number: 20240393222
    Abstract: Provided herein are methods to characterize preparations of recombinant viral particles using analytical ultracentrifugation. Recombinant viral particles include recombinant adeno-associated viral particles, recombinant adenoviral particles, recombinant lentiviral particles and recombinant herpes simplex virus particles. Variant species of recombinant viral particles including empty capsids and recombinant viral particles with variant genomes (e.g., truncated genomes, aggregates, recombinants) can be identified and quantitated. The methods can be used to characterize preparations of recombinant viral particles regardless of the sequence of the recombinant viral genome or the serotype of the recombinant viral capsid.
    Type: Application
    Filed: August 7, 2024
    Publication date: November 28, 2024
    Inventors: Catherine R. O'RIORDAN, Brenda BURNHAM
  • Patent number: D1056193
    Type: Grant
    Filed: September 29, 2022
    Date of Patent: December 31, 2024
    Assignee: Hunter Fan Company
    Inventors: Julia Shaffer, Ryan Lee Eiffert, Patrick R. O'Connell
  • Patent number: D1063047
    Type: Grant
    Filed: October 25, 2022
    Date of Patent: February 18, 2025
    Assignee: Hunter Fan Company
    Inventors: Patrick R. O'Connell, Claire Bernice McRoberts
  • Patent number: D1064246
    Type: Grant
    Filed: October 18, 2021
    Date of Patent: February 25, 2025
    Assignee: Hunter Fan Company
    Inventors: Christopher Streng, Patrick R. O'Connell, Charles William Botkin
  • Patent number: D1065492
    Type: Grant
    Filed: November 23, 2022
    Date of Patent: March 4, 2025
    Assignee: Hunter Fan Company
    Inventors: Ryan Lee Eiffert, Patrick R. O'Connell, Julia Shaffer
  • Patent number: D1065493
    Type: Grant
    Filed: November 30, 2022
    Date of Patent: March 4, 2025
    Assignee: Hunter Fan Company
    Inventors: Julia Shaffer, Ryan Lee Eiffert, Patrick R. O'Connell
  • Patent number: D1065494
    Type: Grant
    Filed: November 30, 2022
    Date of Patent: March 4, 2025
    Assignee: Hunter Fan Company
    Inventors: Ryan Lee Eiffert, Patrick R. O'Connell
  • Patent number: RE50317
    Type: Grant
    Filed: October 13, 2023
    Date of Patent: March 4, 2025
    Assignee: Hunter Fan Company
    Inventors: Patrick R. O'Connell, Christine Marie Holmes Bradley
  • Patent number: D1079926
    Type: Grant
    Filed: September 8, 2022
    Date of Patent: June 17, 2025
    Assignee: Hunter Fan Company
    Inventors: Vladlena Belozerova, John Depler Coleman, Christopher John Murray, Patrick R. O'Connell
  • Patent number: D1078980
    Type: Grant
    Filed: April 15, 2022
    Date of Patent: June 10, 2025
    Assignee: Hunter Fan Company
    Inventors: Vladlena Belozerova, John Depler Coleman, Christopher John Murray, Patrick R. O'Connell