Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.

Abstract: Various embodiments of the present invention disclose techniques for orchestrating a complex data processing scheme for an investigative process using a machine-learning based orchestration model that is trained to optimize the use of computing resources based at least in part on a feedback loop. An input data object associated with an investigative process can be selected for investigation; a predictive data analysis sub-routine for processing the input data object can be intelligently selected from a plurality of predictive data analysis sub-routines by the machine-learning based orchestration model; and a processing orchestration action can be initiated based at least in part on an investigative score output by the predictive data analysis sub-routine. The processing orchestration action can include closing the input data object, continuing to process the input data object with additional predictive data analysis sub-routines, or passing the input data object to a predictive entity for further processing.

Abstract: Provided herein are RNAi molecules for treating Huntington's disease. Further provided herein are expression cassettes, vectors (e.g., rAAV, recombinant adenoviral, recombinant lentiviral, and recombinant HSV vectors), cells, viral particles, and pharmaceutical compositions containing the RNAi. Yet further provided herein are methods and kits related to the use of the RNAi, for example, to treat Huntington's disease.

Abstract: Disclosed herein are methods for reprogramming a somatic cell into a pluripotent stem cell by contacting the somatic cell with one or more antifolate agents, with or without methionine, in vitro for a period of time sufficient to reprogramming the somatic cell and selecting and growing the cells that express one or more stem cell markers. Also disclosed are induced pluripotent stem cells obtained from somatic cells.

Abstract: A device which is attachable to a fastener stack, the device comprising: an attachment element made of shape memory material; and a cap comprising a base having an aperture and a shell having an interior space in fluid communication with the opening, wherein the base supports the shell and is coupled to the attachment element.

Abstract: A safe access system, comprising: a main body configured to attach to mounting hardware on a structure to be accessed; a first connector attached to the main body and configured for connecting to a vertical lifeline; and a second connector attached to the main body and configured for connecting to a power ascender line.

Abstract: A lithium-ion battery may include a cathode, an anode, and a polymer electrolyte. The anode may include a current collector. A patterned lithium storage structure may overlay a patterned current collector. The patterned lithium storage structure may include first regions of a lithium storage material characterized by a first pattern. The patterned current collector may include second regions of recessed portions characterized by a second pattern complementary to the first pattern. The lithium storage material may include at least 40 atomic % amorphous silicon. These and other anodes and lithium-ion batteries are described.

Abstract: An anode for an energy storage device includes a current collector having an electrically conductive layer, a first surface characterized by a first pattern, and a second surface characterized by a complementary second pattern. The anode further includes a patterned lithium storage structure comprising a continuous porous lithium storage layer disposed over the current collector in a pattern corresponding to the first pattern. A method of making an anode for use in an energy storage device includes providing a current collector having an electrically conductive layer, a first surface characterized by a first pattern, and a second surface characterized by a complementary second pattern. A continuous porous lithium storage layer is formed by chemical vapor deposition over the first surface by exposing the current collector to a lithium storage material precursor gas.

Abstract: A topper (38) for a bed extends in longitudinal and lateral directions and includes a fluid flowpath (60) for channeling fluid through the topper from an inlet (62) to an outlet (64). The flowpath is configured to distribute the fluid to a preferred target region (50) of the topper. A bed which includes the topper has a blower (72) connected to the topper inlet for supplying air (88) to the flowpath.

Abstract: A lithium-ion battery may include a cathode, an anode, and a polymer electrolyte. The anode may include a current collector. The current collector may include a metal oxide layer provided in a first pattern overlaying a metal layer. The anode may also include a patterned lithium storage structure. The patterned lithium storage structure may include a continuous porous lithium storage layer overlaying at least a portion of the first pattern of metal oxide. These and other lithium-ion batteries are described.

Abstract: Provided herein are methods to characterize preparations of recombinant viral particles using analytical ultracentrifugation. Recombinant viral particles include recombinant adeno-associated viral particles, recombinant adenoviral particles, recombinant lentiviral particles and recombinant herpes simplex virus particles. Variant species of recombinant viral particles including empty capsids and recombinant viral particles with variant genomes (e.g., truncated genomes, aggregates, recombinants) can be identified and quantitated. The methods can be used to characterize preparations of recombinant viral particles regardless of the sequence of the recombinant viral genome or the serotype of the recombinant viral capsid.