Abstract: Modular fluid path assemblies are provided that include conduit, coupling, and needle portions of a fluid path fluidly coupled to an outlet of a container. The modular fluid path assemblies further include a needle shield having a tip of the needle embedded therein. So configured, in embodiments, the modular fluid path assemblies can be sterilized, a medicament can be filled in the container, and a stopper inserted in the container so that the pre-sterilized and pre-filled modular fluid path assemblies can have a closed container integrity (CCI) seal.

Abstract: The parameters of an optical code are optimized to achieve improved signal robustness, reliability, capacity and/or visual quality. An optimization program can determine spatial density, dot distance, dot size and signal component priority to optimize robustness. An optical code generator employs these parameters to produce an optical code at the desired spatial density and robustness. The optical code is merged into a host image, such as imagery, text and graphics of a package or label, or it may be printed by itself, e.g., on an otherwise blank label or carton. A great number of other features and arrangements are also detailed.

Abstract: Various implementations disclosed herein include devices, systems, and methods that create a 3D video that includes determining first adjustments (e.g., first transforms) to video frames (e.g., one or more RGB images and depth images per frame) to align content in a coordinate system to remove the effects of capturing camera motion. Various implementations disclosed herein include devices, systems, and methods that playback a 3D video and includes determining second adjustments (e.g., second transforms) to remove the effects of movement of a viewing electronic device relative to a viewing environment during playback of the 3D video. Some implementations distinguish static content and moving content of the video frames to playback only moving objects or facilitate concurrent playback of multiple spatially related 3D videos. The 3D video may include images, audio, or 3D video of a video-capture-device user.

Abstract: A heat retentive server includes a chamber defined between an upper shell and a lower shell that are connected to one another. An induction-heatable member is positioned in the chamber, and the induction-heatable member may be heated by electromagnetic induction to a first temperature that is greater than the heat deflection temperature of the upper shell. Buffering material is positioned in the chamber between the induction-heatable member and the upper shell, and the buffering material is adapted for providing predetermined conductive heat transfer from the induction-heatable member to the upper shell so that at least a portion of the upper shell is heated to a second temperature that is greater than the heat deflection temperature of the upper shell. The second temperature is less than the first temperature.

Abstract: The present invention relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof.

Abstract: A threat management facility detects a device on an enterprise network and determines whether the device is one of a set of managed devices for the enterprise network. When the device is not one of the set of managed devices, the threat management facility may selectively direct the device to a portal that provides support to the user of the device while the device awaits admission to the enterprise network. As the user interacts with the portal, the portal may manage admission of unrecognized devices onto the enterprise network while making efficient use of network administrator resources.

Abstract: Hydrocephalus and shunt-related expenditures cost the US system over $2 billion dollars in annual expenses, with 125,000 shunt surgeries per year and an untreated mortality rate estimated at 50-60%. Existing diagnostics are expensive, inaccurate, and often harmful or invasive, and can lead to unnecessary admissions, further testing, or needless surgery. Collaborative efforts between Northwestern materials engineers headed by Dr. John Rogers alongside the leadership of neurological surgeons at Northwestern Memorial Hospital and Lurie Children's Hospital have produced and validated a noninvasive, thermal biosensor capable of diagnosing ventricular shunt malfunction.

Abstract: In an aspect, a cap liner comprises a sintered fluoropolymer layer; and a backing layer; wherein the sintered fluoropolymer layer is in direct physical contact with the backing layer with no intervening layer located there between. In another aspect, a method of forming the cap liner of comprises plasma etching the sintered fluoropolymer layer to form a sintered plasma etched layer; and laminating the sintered plasma etched layer and the backing layer to form the cap liner.

Abstract: A microfluidic system includes a flexible substrate having a skin-facing surface and a back-facing surface; a microfluidic network at least partially embedded in or supported by the flexible substrate; a sensor fluidically connected to the microfluidic network, wherein the microfluidic network is configured to transport a biofluid from a skin surface to the sensor; and a capping layer, having a capping layer skin-facing surface and a back-facing surface, wherein the back-facing surface of the capping layer is attached to the skin-facing surface of the substrate. The flexible substrate is at least partially formed of a thermoplastic elastomer or a polymer configured to provide a high barrier to vapor or liquid water transmission.

Abstract: The invention provides a versatile sensing platform for sensing and analysis of biofluids, particularly well-suited for sensing and analysis of sweat. Systems of the invention allows for sensitive and selective detection of a range of analytes in sweat including metabolites, electrolytes and biomarkers. Systems of the invention provide a noninvasive and accurate means for quantitative characterization of important sweat characteristics including sweat volume, sweat loss and sweat rate. Systems of the invention are compatible with materials and device geometries for important class of conformal tissue mounted electronic devices, including epidermal electronic devices.

Abstract: In an aspect, a cap liner comprises a sintered fluoropolymer layer; and a backing layer; wherein the sintered fluoropolymer layer is in direct physical contact with the backing layer with no intervening layer located there between. In another aspect, a method of forming the cap liner of comprises plasma etching the sintered fluoropolymer layer to form a sintered plasma etched layer; and laminating the sintered plasma etched layer and the backing layer to form the cap liner.

Abstract: A shrink sleeve label is provided. Broadly, the shrink sleeve label includes an unshrunken shrink film and a varnish applied to the shrink film. The varnish is applied to the shrink film in an application area to reduce shrinking of the shrink film in the area where the varnish is applied. Additionally, the shrink sleeve label includes a secondary label that is applied to a surface of the shrink film. Further, a method of manufacturing a shrink sleeve label is provided. Broadly, the method includes providing a shrink film and seaming the shrink film into a tubular shape. Additionally, the method includes providing a secondary label and applying the secondary label to the shrink film. The secondary label is applied to the shrink film before the shrink film is applied to an article.

Abstract: In an aspect, a cap liner comprises a sintered fluoropolymer layer; and a backing layer; wherein the sintered fluoropolymer layer is in direct physical contact with the backing layer with no intervening layer located there between. In another aspect, a method of forming the cap liner of comprises plasma etching the sintered fluoropolymer layer to form a sintered plasma etched layer; and laminating the sintered plasma etched layer and the backing layer to form the cap liner.

Abstract: A fiber Bragg grating (FBG) security component for single-party and multi-party monitoring is provided. The security component includes an optical fiber having a plurality of Bragg gratings. The Bragg gratings provide a spectral response that is randomized based on the manufacture of the security component. For single-party use, the spectral response provides a reproducible spectral signature when interrogated with an optical signal. For multi-party use, each party applies a known optical interrogation signal to the security component and applies an external stress known only to the respective monitoring party. The resulting shift in the spectral signature is unique to each monitoring party, making it extremely difficult to successfully counterfeit the security component's response for all such parties.

Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.

Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.

Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.

Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.

Abstract: A fitting or connector for use in constructing a tubing assembly is made by bonding an olefin gasket to an end face of a polypropylene fitting member. The gasket is bonded to the fitting member via a heat fusion technique that causes localized melting together of the gasket and the fitting and generates a composite fitting or connector.

Abstract: A pressure sensitive adhesive article that includes: a backing having two major surfaces, at least one of which has a pressure sensitive adhesive layer disposed thereon, the pressure sensitive adhesive layer having an average thickness of 25 microns to 50 microns and including: a styrene-isoprene-containing block copolymer including a styrene-isoprene diblock copolymer and a styrene-isoprene-styrene triblock copolymer; a tackifier; and an oil; an article that includes recycled corrugate having the pressure sensitive adhesive article adhered thereto; a method of sealing a package using the pressure sensitive adhesive article; and a method of making the pressure sensitive adhesive article.