Patents by Inventor R. Robert Balcarcel

R. Robert Balcarcel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF ADJUSTING THE PH OF A CELL CULTURE MEDIUM
    Publication number: 20240117401
    Abstract: Methods for adjusting the pH of a cell culture medium, methods for culturing cells in a pH-adjusted cell culture medium, and methods for making a polypeptide expressed by cells cultured in a pH-adjusted cell culture medium are described. Also described are systems for determining how much acid or base should be added to a cell culture medium to obtain a desired pH. The methods include a charge balance model that includes parameters for a functional relationship between a concentration of dissolved carbon dioxide in the cell culture medium, a mole fraction of gaseous carbon dioxide applied to the cell culture medium, a concentration of net medium acids in the cell culture medium, and the desired medium pH.
    Type: Application
    Filed: February 11, 2022
    Publication date: April 11, 2024
    Inventors: R. Robert BALCARCEL, Tam DUONG
  • Apparatus and Methods for Using Biological Material to Discriminate an Agent
    Publication number: 20120156763
    Abstract: An apparatus and methods for using biological material to discriminate an agent. In one embodiment of the present invention, the method includes the steps of providing at least one cell, exposing at least one cell to an agent, measuring the response of the cell to the agent in terms of a physical quantity related to at least one of the cellular physiological activities of the cell, and identifying the agent from the measured response. The method further includes the step of quantifying the agent from the measured response.
    Type: Application
    Filed: August 25, 2011
    Publication date: June 21, 2012
    Applicant: VANDERBILT UNIVERSITY
    Inventors: John P. Wikswo, Franz J. Baudenbacher, R. Robert Balcarcel, Theodore A. Bapty, David Cliffel, Sven Eklund, Owen McGuinness, Todd Monroe, Ales Prokop, Mark Andrew Stremler, Andreas Augustinus Werdich, Yang Yuansheng
  • Device and methods for detecting the response of a plurality of cells to at least one analyte of interest
    Patent number: 7713733
    Abstract: An apparatus and methods for detecting at least one analyte of interest either produced or consumed by a plurality of cell. In one embodiment of the present invention, the method includes the steps of providing a housing defining a chamber, placing a plurality of cells in the chamber, and simultaneously detecting at least two analytes of interest either produced or consumed by the plurality of cells in the chamber.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: May 11, 2010
    Assignee: Vanderbilt University
    Inventors: David Cliffel, Franz J. Baudenbacher, John P. Wikswo, Sven Eklund, R. Robert Balcarcel, Jonathan M. Gilligan
  • Apparatus and methods for monitoring the status of a metabolically active cell
    Patent number: 7704745
    Abstract: An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the status of the cell from the measured intracellular or extracellular signaling of the cell.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: April 27, 2010
    Assignee: Vanderbilt University
    Inventors: Franz Baudenbacher, John P. Wikswo, R. Robert Balcarcel, David Cliffel, Sven Eklund, Jonathan Mark Gilligan, Owen McGuinness, Todd Monroe, Ales Prokop, Mark Andrew Stremler, Andreas Augustinus Werdich
  • Apparatus and methods for monitoring the status of a metabolically active cell
    Publication number: 20090305319
    Abstract: An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the status of the cell from the measured intracellular or extracellular signaling of the cell.
    Type: Application
    Filed: August 6, 2002
    Publication date: December 10, 2009
    Inventors: Franz J. Baudenbacher, John P. Wikswo, R. Robert Balcarcel, David Cliffel, Sven Eklund, Jonathan Mark Gilligan, Owen McGuinness, Todd Monroe, Ales Prokop, Mark Andrew Stremler, Andreas Augustinus Werdich