Abstract: A focused treatment tip (FTT) for controlling the evaporation rate and providing targeted delivery of low temperature liquified gases for contact with living tissue includes a contoured body. When filled with liquified gas, the device insulates the gas from waste heat sources, such as the surrounding environment. The device can control the evaporation rate of the liquified gas at the treatment site. The controlled evaporation rate affects the rate of heat transfer from the treated tissue allowing for controlled exposure times and desired outcomes. The device can be used with various application tips to further define the target tissue area to be treated while minimizing collateral damage to surrounding tissue and isolating the gas within the contoured body and focusing heat transfer to the desired treatment area. The device may use transparent materials that make the treatment visible to the operator while the liquified gas is evaporating.

Abstract: A focused treatment tip (FTT) for controlling the evaporation rate and providing targeted delivery of low temperature liquified gases for contact with living tissue includes a contoured body. When filled with liquified gas, the device insulates the gas from waste heat sources, such as the surrounding environment. The device can control the evaporation rate of the liquified gas at the treatment site. The controlled evaporation rate affects the rate of heat transfer from the treated tissue allowing for controlled exposure times and desired outcomes. The device can be used with various application tips to further define the target tissue area to be treated while minimizing collateral damage to surrounding tissue and isolating the gas within the contoured body and focusing heat transfer to the desired treatment area. The device may use transparent materials that make the treatment visible to the operator while the liquified gas is evaporating.

Abstract: A flow modulation device 300 for controlling a rheological state of a dispensed pressurized fluid includes a porous element 304 and an exit tube. The porous element 304 is in fluid communication with a distal end of an outlet tube 303 and receives pressurized fluid in a first rheological state. The porous element 304 includes a plurality of channels that divide a flow channel into a plurality of flow paths through which the pressurized fluid flows and that modulates the flow of the pressurized fluid. The exit tube 305 includes proximal end 355 and distal end 345 and an intermediate body including a sidewall 365 defining a hollow internal lumen 375. The exit tube 305 is in fluid communication with the porous element 304 and receives the modulated pressurized fluid from the plurality of flow paths and refocuses the fluid to dispense the pressurized fluid in a second rheological state.

Abstract: The portable cryosurgical device is economical, easy to use and operate, and delivers cryogenic material such as nitrous oxide and carbon dioxide gas in any direction or orientation. The delivered materials destroy target tissue using extremely cold temperatures and the abrasives formed when the cryogenic material becomes a solid. The device includes a portable countertop enclosure housing a cryogen source, a cryogen flow tube in fluid communication with the cryogen source, and a flow path assembly. The flow path assembly includes a valve between the cryogen source and the cryogen flow tube having substantially zero dead volume. The flow path assembly can include a quick-connect cryogen tank adapter and an in-line cryogen filter. The flow path assembly delivers liquefied compressed gas from the cryogen source to a terminal end of the cryogen flow tube without a phase change occurring in the flow path.

Abstract: A flow modulation device 300 for controlling a rheological state of a dispensed pressurized fluid includes a porous element 304 and an exit tube. The porous element 304 is in fluid communication with a distal end of an outlet tube 303 and receives pressurized fluid in a first rheological state. The porous element 304 includes a plurality of channels that divide a flow channel into a plurality of flow paths through which the pressurized fluid flows and that modulates the flow of the pressurized fluid. The exit tube 305 includes proximal end 355 and distal end 345 and an intermediate body including a sidewall 365 defining a hollow internal lumen 375. The exit tube 305 is in fluid communication with the porous element 304 and receives the modulated pressurized fluid from the plurality of flow paths and refocuses the fluid to dispense the pressurized fluid in a second rheological state.

Abstract: Systems, devices, and methods for delivery of a topical substance, including medicaments and/or cosmetic formulas, with carbon dioxide to the surface of the skin. The systems regulate the pH, temperature and viscosity of the topical substance, which provides benefits to the treatment of the skin. For beauty treatments, the systems lessen wrinkles of the skin and hydrate at the same time. For medicaments with active ingredients, the systems enhance delivery and ionic state using pH adjustment. The systems include devices that contain a reservoir of carbon dioxide, which flows through a heat control path where the temperature of the carbon dioxide is adjusted to a desired setting. The temperature-controlled carbon dioxide then mixes with the topical substance in a chamber, which is pressed against or applied to the skin to achieve the benefits.

Abstract: The portable cryosurgical device is economical, easy to use and operate, and delivers cryogenic material such as nitrous oxide and carbon dioxide gas in any direction or orientation. The delivered materials destroy target tissue using extremely cold temperatures and the abrasives formed when the cryogenic material becomes a solid. The device includes a portable countertop enclosure housing a cryogen source, a cryogen flow tube in fluid communication with the ciyogen source, and a flow path assembly. The flow path assembly includes a valve between the ciyogen source and the cryogen flow tube having substantially zero dead volume. The flow path assembly can include a quick-connect cryogen tank adapter and an in-line ciyogen filter. The flow path assembly delivers liquefied compressed gas from the cryogen source to a terminal end of the cryogen flow tube without a phase change occurring in the flow path.

Abstract: A focused treatment tip (FTT) for controlling the evaporation rate and providing targeted delivery of low temperature liquified gases for contact with living tissue includes a contoured body. When filled with liquified gas, the device insulates the gas from waste heat sources, such as the surrounding environment. The device can control the evaporation rate of the liquified gas at the treatment site. The controlled evaporation rate affects the rate of heat transfer from the treated tissue allowing for controlled exposure times and desired outcomes. The device can be used with various application tips to further define the target tissue area to be treated while minimizing collateral damage to surrounding tissue and isolating the gas within the contoured body and focusing heat transfer to the desired treatment area. The device may use transparent materials that make the treatment visible to the operator while the liquified gas is evaporating.

Abstract: A flow modulation device 300 for controlling a rheological state of a dispensed pressurized fluid includes a porous element 304 and an exit tube. The porous element 304 is in fluid communication with a distal end of an outlet tube 303 and receives pressurized fluid in a first rheological state. The porous element 304 includes a plurality of channels that divide a flow channel into a plurality of flow paths through which the pressurized fluid flows and that modulates the flow of the pressurized fluid. The exit tube 305 includes proximal end 355 and distal end 345 and an intermediate body including a sidewall 365 defining a hollow internal lumen 375. The exit tube 305 is in fluid communication with the porous element 304 and receives the modulated pressurized fluid from the plurality of flow paths and refocuses the fluid to dispense the pressurized fluid in a second rheological state.

Abstract: A sample collector and test device is disclosed. The sample collector and test device may be used together as a diagnostic tool for collecting and assay of analytes contained in a sample. A sample collector is also disclosed which may be used with existing sample containers and or test devices. The sample collector may indicate sample adequacy when a sufficient volume of sample has been collected for assay and may also include a sample retaining feature which retains a portion of expressed sample for confirmatory testing, if desirable. The sample collector may also include a mechanism for expressing sample in a sample collector and/or test device. A test device is also disclosed for retaining and assay of an expressed sample. The disclosed test device may be used with existing sample collectors. In a preferred embodiment, test device is used with a preferred sample collector.

Abstract: A dispensing head for dispensing a cryogenic fluid may comprise a flow passage configured to be placed in flow communication with a reservoir containing a cryogenic fluid, the flow passage defining a flow passage inlet opening configured to receive the cryogenic fluid from the reservoir, and a flow passage outlet opening opposite the flow passage inlet opening. The dispensing head may further comprise a dispensing member configured to dispense the cryogenic fluid, the dispensing member defining a lumen having a lumen inlet opening and a lumen outlet opening; and at least one porous member disposed in the flow passage, the at least one porous member being configured as a primary flow regulation mechanism to limit a flow rate of the cryogenic fluid as it flows from the reservoir to the lumen outlet opening.

Abstract: Self-contained disposable cryosurgical devices dispense a cryogenic fluid, such as a stream of liquid nitrous oxide, carbon dioxide or argon. The cryosurgical devices include a container, including a reservoir containing a cryogenic fluid, a flow passage configured to receive the cryogenic fluid from the reservoir, a valve assembly configured in an ergonomic housing, and a dispensing head. The device further includes at least one filter disposed in the flow passage configured to facilitate the flow of the cryogenic fluid. The valve assembly includes a valve body and valve slide that is actuated to effect the flow of the cryogenic fluid through the flow passage to patient target. The housing includes an activation lever with an eccentric hub that primes the device for use when a container is loaded into the housing and the activation lever is closed.

Abstract: A sample collector and test device is disclosed. The sample collector and test device may be used together as a diagnostic tool for collecting and assay of analytes contained in a sample. A sample collector is also disclosed which may be used with existing sample containers and or test devices. The sample collector may indicate sample adequacy when a sufficient volume of sample has been collected for assay and may also include a sample retaining feature which retains a portion of expressed sample for confirmatory testing, if desirable. The sample collector may also include a mechanism for expressing sample in a sample collector and/or test device. A test device is also disclosed for retaining and assay of an expressed sample. The disclosed test device may be used with existing sample collectors. In a preferred embodiment, test device is used with a preferred sample collector.

Abstract: A sample collector and test device is disclosed. The sample collector and test device may be used together as a diagnostic tool for collecting and assay of analytes contained in a sample. A sample collector is also disclosed which may be used with existing sample containers and or test devices. The sample collector may indicate sample adequacy when a sufficient volume of sample has been collected for assay and may also include a sample retaining feature which retains a portion of expressed sample for confirmatory testing, if desirable. The sample collector may also include a mechanism for expressing sample in a sample collector and/or test device. A test device is also disclosed for retaining and assay of an expressed sample. The disclosed test device may be used with existing sample collectors. In a preferred embodiment, test device is used with a preferred sample collector.

Abstract: A lateral flow test strip for the analysis of a sample featuring numerous capture zones arranged in an array such that each capture zone is substantially equidistant from the sample containing area. The sample does not pass through another capture zone to reach any one of the other capture zones. The capture zones are preferably arranged in a linear array perpendicular to the flow of the sample through the lateral flow test strip. The lateral flow test strip allows for an increased number of simultaneous analyses of numerous analytes from one sample to occur on one lateral flow test strip.