Abstract: The present disclosure relates to pharmaceutical compounds of the Formula (I), (Ia), (Ib), or (Ic) or a pharmaceutically acceptable salt or composition thereof. Also provided are methods of use of TRPML modulators for treating disorders, the modulators including compounds of the Formula (I), (Ia), (Ib), or (Ic). Such methods of use include treatment of ciliopathies.

Abstract: An advanced chassis structure design offers more battery storage spaces than same-class electric vehicles. The chassis structure provides four battery storage spaces. The significance of these additional storage areas lies in their direct impact on extending the driving range of the vehicle. The chassis structure design further addresses the issue of battery replacement in an electric vehicle chassis. Typically, when an electric vehicle runs out of battery, it takes several minutes or even hours for the battery to be fully recharged. When the battery is broken, the replacement process often involves significant disassembly, which is also time-consuming. With the chassis structure design, the battery is positioned underneath the chassis and fastened within the battery tray and protective battery case. This means that when it comes to battery replacement, the battery can be swapped just by removing a few screws.

Abstract: A tub and shower diverter assembly includes a manifold sub-assembly configured to be detachably coupled to, and in fluid communication with, an existing waterway connector of a conventional tub and shower diverter system. The manifold sub-assembly includes a manifold, a flow control valve coupled to the manifold, and a tolerance adjuster. The flow control valve is configured to provide a flow of water to a tub or a shower device. The tolerance adjustor is coupled to the flow control valve and is configured to be selectively adjusted to change an axial position of the tolerance adjustor relative to a wall adjacent the manifold sub-assembly.

Abstract: Vehicle charge assist system and method include receiving image data generated by an optical sensor. The image data depicts at least a portion of a charging device and at least a portion of a vehicle approaching the charging device. The system and method analyze the image data that is received to detect the vehicle, and based on the image data that is analyzed, generate guidance instructions for communication to the vehicle. The guidance instructions are configured to at least one of assist with or control movement of the vehicle such that a vehicle contact interface mounted on the vehicle aligns with the charging device.

Abstract: A method of producing a ceramic matrix composite material component is provided. The method includes that steps of: a) producing a preform having one or more ceramic constituents, the preform being porous with internal voids; and b) applying at least one layer of a first material to the preform using an atomic layer deposition (ALD) process to decrease a porosity of the preform.

Abstract: Cellular base station antenna concealments, such as palm and tree concealments, utilize artificial branches with nonmetallic (e.g., polymeric) fasteners to avoid loose metal-to-metal connections to mitigate the generation of passive intermodulation (PIM) interference by the branches. Representative embodiments include “palm concealments” with low-PIM artificial palm fronds, and “tree concealments” with low-PIM artificial tree branches. That is, “low-PIM fronds” and “low-PIM tree branches” are two representative examples of “low-PIM branches” illustrating representative embodiments of the invention. The low-PIM palm frond includes a nonmetallic (e.g., polymeric) fasteners and sleeve positioned between a metal frond shaft and a metal frond receiver. The low-PIM tree branch includes nonmetallic (e.g., polymeric) fasteners as the only low-PIM isolators added to conventional tree branch assemblies to avoid PIM generation by the tree branch assembly.

Abstract: A ceramic article includes a ceramic matrix composite that has a porous reinforcement structure and a ceramic matrix within pores of the porous reinforcement structure. The ceramic matrix composite includes a surface zone comprised of an exterior surface of the ceramic matrix composite and pores that extend from the exterior surface into the ceramic matrix composite. A glaze material seals the surface zone within the pores of the surface zone and on the exterior surface of the surface zone as an exterior glaze layer on the ceramic matrix composite. The glaze material is a glass or glass-ceramic material. The ceramic matrix composite includes an interior zone under the surface zone, and the interior zone is free of any of the glaze material and has a greater porosity than the surface zone.

Abstract: An article includes a ceramic-based substrate and a barrier layer on the ceramic-based substrate. The barrier layer includes a matrix of barium-magnesium alumino-silicate or SiO2, a dispersion of silicon oxycarbide particles in the matrix, and a dispersion of particles, of the other of barium-magnesium alumino-silicate or SiO2, in the matrix.

Abstract: The tub and shower diverter assembly includes an escutcheon, a manifold sub-assembly, and a handle assembly. The manifold sub-assembly is fluidly coupled to an existing waterway connector of an existing conventional tub and shower diverter system. The manifold sub-assembly includes a mixing valve at least partially disposed through the escutcheon and coupled to the manifold sub-assembly by a valve nut. The handle assembly is coaxially aligned with the mixing valve. The handle assembly includes a base insertably coupled to the valve nut and a handle rotatably coupled to the base. The handle is threadably coupled to the mixing valve. The escutcheon abuts a wall when the handle is threadably coupled to the mixing valve.

Abstract: A method of manufacturing a CMC structure includes infiltrating a porous substrate with a composite material and performing a first densification on the infiltrated porous substrate, forming a first densified porous substrate, wherein the first densification includes techniques selected from the group of techniques comprising photonic curing, photonic sintering, pulsed thermal heating, or combinations thereof.

Abstract: The present disclosure relates to pharmaceutical compounds of the Formulas I, Ia, Ib, or Ic or a pharmaceutically acceptable salt or composition thereof. Also provided are methods of use of TRPML modulators for treating disorders, the modulators including compounds of the Formulas I, Ia, Ib, or Ic. Such methods of use include treatment of ciliopathies.

Abstract: Disclosed is a method of making a high temperature fiber including incorporating an inorganic atom into a polymer precursor fiber to form a modified polymer precursor fiber and converting the modified polymer precursor fiber to a high temperature fiber having a bonded inorganic atom.

Abstract: A fabrication apparatus for fabricating ceramic structures of controlled size and composition is provided. The fabrication apparatus includes an additive manufacturing machine configured to dispense preceramic materials in a printed pattern, the printed pattern corresponding to the ceramic structures of the controlled size and composition, a radiation emitter configured to emit curing radiation toward the printed pattern to cure the preceramic materials and a lamp element configured to shine light on the preceramic materials to convert the preceramic materials to ceramics.

Abstract: An article includes a silicon oxycarbide-based layer that has Si, O, and C in a covalently bonded network. The silicon oxycarbide-based layer has first and second opposed surfaces. A calcium-magnesium alumino-silicate-based layer is interfaced with the first surface of the silicon oxycarbide-based layer.

Abstract: The present disclosure relates to methods of treating a ciliopathy, the method comprising administering to a patient in need thereof a therapeutically effective amount of a compound or pharmaceutical composition thereof, wherein the compound modulates a TRPML ion channel. The disclosure also relates to pharmaceutical compounds of Formula (III) and subformulas thereof, or a pharmaceutically acceptable salt or composition thereof, and methods of their use for modulating TRPML ion channels, and for treating disorders.

Abstract: Disclosed is a method of making high temperature fiber including incorporating an inorganic atom into a polymer precursor fiber to form a modified polymer precursor fiber and converting the modified polymer precursor fiber to a high temperature fiber having a bonded inorganic atom.

Abstract: A photo-curable liquid composition for additive manufacturing of silicon-containing carbide ceramic includes a polymethylvinylsilane (PMVS) resin that has photo-reactivity over a first photo-wavelength absorption range and a photo-initiator additive mixed with the PMVS resin. The photo-initiator additive has photo-reactivity over a second photo-wavelength absorption range that has an overlapping wavelength range with the first photo-wavelength absorption range. The PMVS and the photo-initiator additive are reactive to polymerize upon exposure to radiation having a wavelength in the overlapping wavelength range.

Abstract: A brake component is disclosed. In various embodiments, the brake component includes a ceramic matrix composite (CMC) structure including a plurality of nominally dense plies, interleaved with a plurality of interlayers, wherein the plurality of nominally dense plies and the plurality of interlayers are bonded by at least one of a Field Assisted Sintering Technique (FAST), a Spark Plasma Sintering (SPS) process, or a localized heating process. In various embodiments, the brake component is a rotor disk or a stator disk.

Abstract: Disclosed is a method of making high temperature fiber including chemically bonding high temperature material to a fiber template at a first temperature to form a precursor fiber and processing the precursor fiber at a second temperature to form the high temperature fiber. The first temperature does not equal the second temperature. Also disclosed are high temperature fibers made by the method.