Publication number: 20040138170
Abstract: The compounds represented by the formulae (I) wherein X is selected from the group consisting of: O, S, N—R1, and CHR1; Y and Y′ is individually selected from H, OR1, NR1R2, and N3 Z and Z′ is individually selected from II, OR1, and NR1R2 R=II, formula (II), formula (III), or formula (III), R1 and R2 is selected from H, alkyl, acyl, aryl which may be substituted or unsubstituted, R3 is selected from H, alkyl, alkenyl, alkynyl, aryl, acyloxyalkyl, and pivaloyloxyalkyl, B is selected from 5 or 6-substituted uracil or cytosine, pseudouracil, N-substituted pseudouracil, 2-thiouracil, 2-thiocytosine, 5- or 6-substituted 2-thiouracil and 2-thiocytosine, 6-azauracil, 5-azacytosine, 8-azapurines, and 7-aza-8-deazapurines. Substitutions may be halosubstituted alkyl, halosubstituted alkenyl, halosubstituted alkynyl, halosubstituted aryl, alkylthio, or NR1R2.
Type:
Application
Filed:
March 3, 2004
Publication date:
July 15, 2004
Inventors:
John A. Montgomery, Yarlagadda S Babu, Pooran Chand, R Scott Rowland