Abstract: The disclosure herein relates to antipurinergic compounds and uses thereof. Specifically, the disclosure relates to the use of antipurinergic compounds to treat neurodevelopmental disorders. More specifically, the disclosure relates to the use of suramin for the treatment of autism spectral disorders (ASDs). More specifically, the present disclosure relates to non-intravenously administered suramin for the treatment of ASDs.

Abstract: Devices for treating aneurysms are disclosed. The devices are adapted and configured to modify blood flow at the aneurysm. More specifically, the invention discloses devices for treating cerebral aneurysms using devices adapted and configured to be delivered to a blood vessel in the brain on a distal tip of a microcatheter. The aneurysm devices comprise: a device adapted to be delivered to a blood vessel aneurysm on a distal tip of a catheter and further adapted to modify blood flow at the aneurysm.

Abstract: Described herein are devices and systems for transdiscal fusion of vertebrae and methods for fusing adjacent vertebra. A system may include a device with two anchorable members connectable by an intervening connector forming a continuous passageway therethrough. An anchorable member may have a constrained non-anchoring configuration and a released anchoring configuration. The anchoring configuration typically includes a radially-expanded structure such as a plurality of struts. After positioning the anchorable members into two adjacent vertebral bodies, the anchorable members may be released from their constrained configuration so that they radially self-expand, anchoring the device across the fracture. A flowable bone-filling material may be conveyed into the passageway of the device after implantation, stabilizing it further in the vertebral implantation site.

Abstract: The invention relates to a system for stabilizing a bone fracture and methods for applying the system. The system includes a device with two anchorable members with an intervening connector and a passageway through the device. The anchorable members have a constrained non-anchoring configuration and a released anchoring configuration. The anchoring configuration includes a radially-expanded structure such as a plurality of struts. After implantation across a fracture site, the anchorable members are released from their linearly constrained configuration, and structural features radially self-expand, anchoring the device across the fracture. A flowable bone-filling material may be conveyed into the passageway of the device after implantation. The composition fills the space within the expanded structures of the anchorable members and flows into space surround the device, stabilizing it further in the implantation site.

Abstract: Described herein are devices, systems, and methods for treating bone. Self-expanding stabilization devices for repairing bone may include one or more bone screw attachment regions for attaching a bone screw after or before inserting the device into a subject. The stabilization device may be attached using an inserter. These stabilization devices may be used with bone screws having multiple parts or components. Thus, the stabilization devices described herein may be used to help secure one or more bone screws (in particular pedicle screws) in a subject.